Patents by Inventor Yariv Wine

Yariv Wine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOCLONAL ANTIBODY AND USES THEREOF FOR THE TREATMENT AND DIAGNOSIS OF MULTIDRUG-RESISTANT PATHOGENIC BACTERIAL INFECTIONS
    Publication number: 20240166729
    Abstract: The invention relates to human antibodies specific for Type III secretion system (T3SS), variants and biosimilars thereof. The human antibodies of the invention are specifically directed at the EspB protein. The preset disclosure further provides compositions and uses of the disclosed antibodies in treatment and diagnosis of MDR pathogenic bacterial infections.
    Type: Application
    Filed: April 14, 2021
    Publication date: May 23, 2024
    Inventors: Yariv WINE, Neta SAL-MAN, Yaron HILLMAN, Dan LUSTIGER, Jenia GERSHBERG, Dan EVEN
  • Proteomic identification of antibodies
    Patent number: 10175249
    Abstract: Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects, methods for determining amino acid sequences of serum antibody CDR3 and abundancy levels are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and the frequency thereof in biological samples are provided. Furthermore, the invention provides methods for identification and generation of antibodies or antigen-binding fragments that comprise highly-represented CDR domains.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: January 8, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jason Lavinder, Daniel Boutz, Yariv Wine, Edward M. Marcotte, George Georgiou
  • PROTEOMIC IDENTIFICATION OF ANTIBODIES
    Publication number: 20160146830
    Abstract: Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects, methods for determining amino acid sequences of serum antibody CDR3 and abundancy levels are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and the frequency thereof in biological samples are provided. Furthermore, the invention provides methods for identification and generation of antibodies or antigen-binding fragments that comprise highly-represented CDR domains.
    Type: Application
    Filed: September 25, 2015
    Publication date: May 26, 2016
    Inventors: Jason LAVINDER, Daniel BOUTZ, Yariv WINE, Edward M. MARCOTTE, George GEORGIOU
  • Proteomic identification of antibodies
    Patent number: 9146241
    Abstract: Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects, methods for determining amino acid sequences of serum antibody CDR3 and abundancy levels are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and the frequency thereof in biological samples are provided. Furthermore, the invention provides methods for identification and generation of antibodies or antigen-binding fragments that comprise highly-represented CDR domains.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: September 29, 2015
    Assignee: Board of Regents, the University of Texas System
    Inventors: Jason Lavinder, Yariv Wine, Danny Boutz, Edward Marcotte, George Georgiou