Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.

Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.

Abstract: A method and system for mine design utilising mathematical modelling and optimisation based on mathematical modelling of connected bubbles. A mathematical model, based on mathematical modelling of behavior of connected bubbles, is applied to the 3D block model for a mine to cluster geometric elements from the 3D block model based on physical location and properties of the physical material for each of the geometric elements, and selecting at least one set of a plurality of contiguous geometric elements for extraction based on the clustering. Each set of a plurality of contiguous blocks can be associated with a phase of a mining process.

Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.

Abstract: An ultrasound test apparatus for polymeric materials (e.g., plastic pipes) includes a low-absorption housing that at least partially encloses an ultrasound transducer, wherein the transducer emits a low frequency wide angle ultrasound beam with a narrow bandwidth. In especially preferred configurations and methods, the apparatus will detect flaws in polymeric pipes, and especially in welds or stressed zones of such pipes, wherein defects of less than 4% of the wall thickness (up to 4 inches) are detected. Further disclosed are configurations and methods for nondestructive detection of lack-of-fusion defects in polymeric pipes.

Abstract: An ultrasound test apparatus for polymeric materials (e.g., plastic pipes) includes a low-absorption housing that at least partially encloses an ultrasound transducer, wherein the transducer emits a low frequency wide angle ultrasound beam with a narrow bandwidth. In especially preferred configurations and methods, the apparatus will detect flaws in polymeric pipes, and especially in welds or stressed zones of such pipes, wherein defects of less than 4% of the wall thickness (up to 4 inches) are detected. Further disclosed are configurations and methods for nondestructive detection of lack-of-fusion defects in polymeric pipes.