Abstract: The disclosure provides methods for improving the function of systems regimens, devices by identifying, quantifying, and implementing at least one inherent variability pattern which is based on patterns learned from a specific subject or from other subjects including subject's variability patterns, such as, DNA, genes, nucleic acids, RNA, proteins, cells, organs, biological pathway(s), or whole body variability. There are provided herein devices, systems, and methods for real time or delayed altering of the parameters of system's regimens, for improving biological systems functions. Any system used by humans, or affect human function, wherein the parameters are updated using inherent variabilities signatures with and without other individualized patterns from a subject or from other subjects, can increase the accuracy and efficacy of the system for achieving the desired goal.

Abstract: There are provided herein a system and a computer implemented method for preventing, mitigating or treating partial/complete loss of effect of one or more drugs or medical devices administered to or used by a subject in need thereof due to adaptation, tolerance, and/or tachyphylaxis, and/or for preventing, mitigating or treating non-responsiveness to one or more drugs, maximizing therapeutic effect of one or more drugs, or for improving target or non-target organ/organs response to therapy, the system/method include (processing circuit configured to): receiving a plurality of physiological or pathological parameters of the subject; applying a machine learning algorithm on the plurality of physiological or pathological parameters; and determining a subject-specific administration regimen of a drug or a medical treatment, wherein the administration regimen comprises drug administration parameters, cell/tissue/organ stimulation parameters, adjuvant parameters or any combination thereof; wherein the administratio

Abstract: The invention provides methods and systems for the treatment and diagnosis of pathologic disorders by modulating a physiological state of a target biological entity via exposure of the target entity to a single or a plurality of triggered entities and for transferring of information in a non-direct way and as part of virtual reality interactive environment.

Abstract: A gastrointestinal stimulation devices including a random stimulation delivery mechanism(s), configured to provide stimuli to a bodily tissue in a vicinity of the stimulation capsule, the provided random stimuli being characterized by a stimulation parameter, and a control circuitry in communication with said physical stimulation delivery mechanism, and configured to set and alter the stimulation parameter non-systematically, thereby altering the characterization of the stimuli provided to the bodily tissue. The algorithm may be patient tailored, and may have a learning machinery which responds to data being received from the patient.

Abstract: A gastrointestinal stimulation devices including a random stimulation delivery mechanism(s), configured to provide stimuli to a bodily tissue in a vicinity of the stimulation capsule, the provided random stimuli being characterized by a stimulation parameter, and a control circuitry in communication with said physical stimulation delivery mechanism, and configured to set and alter the stimulation parameter non-systematically, thereby altering the characterization of the stimuli provided to the bodily tissue. The algorithm may be patient tailored, and may have a learning machinery which responds to data being received from the patient.

Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

Abstract: The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects. This method comprises the administration of a naturally occurring, mammalian intermediary metabolite or T cell receptor ligand, preferably a glucosylceramide, to a mammalian subject. In a preferred embodiment, such mammalian subjects are human beings.

Abstract: Methods of treating liver diseases are provided. Accordingly there is provided a method of treating a liver disease selected from the group consisting of fatty liver disease and chronic liver rejection in a subject in need thereof, wherein said liver disease is not associated with genetic alpha-1 anti-trypsin (AAT) deficiency, the method comprising administering to the subject a therapeutically effective amount of AAT.

Abstract: There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter.

Abstract: The present disclosure provides systems regimens, devices and methods for improving organ function by challenged-exercise, training, and/or education and/or nutritional regimens, or devices intended for improving organ performance, and for prevention and treatment of loss of an effect to exercise regimens in healthy and chronic subjects, or lack of full responsiveness to exercise, training, nutritional or education regimens in subjects who wish to improve the function of their organs, or with chronic diseases. There are provided herein devices, systems, and methods for real time or delayed altering of the parameters of training regimens and/or time of administration and/or combining different exercise, training, nutrition or education regimens, for improving the long term effect of the regimen.

Abstract: Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), including those also suffering from type II diabetes mellitus (T2DM), with a delayed release pharmaceutical composition comprising 6-mercaptopurine are disclosed.

Abstract: There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter.

Abstract: The present invention relates to methods for treating psoriasis and other indications by inhibiting leptin activity.

Abstract: The present disclosure provides systems, devices and methods for providing abdominal or any other organ stimulation for affecting a physiological change, wherein the stimulation parameters are continuously, semi continuously, or conditionally being updated based on measurements and inputs provided to a computer circuitry configured to facilitate machine learning capabilities.

Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

Abstract: The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects. This method comprises the administration of a naturally occurring, mammalian intermediary metabolite or T cell receptor ligand, preferably a glucosylceramide, to a mammalian subject. In a preferred embodiment, such mammalian subjects are human beings.

Abstract: The disclosure provides methods for improving the function of systems regimens, devices by identifying, quantifying, and implementing at least one inherent variability pattern which is based on patterns learned from a specific subject or from other subjects including subject's variability patterns, such as, DNA, genes, nucleic acids, RNA, proteins, cells, organs, biological pathway(s), or whole body variability. There are provided herein devices, systems, and methods for real time or delayed altering of the parameters of system's regimens, for improving biological systems functions. Any system used by humans, or affect human function, wherein the parameters are updated using inherent variabilities signatures with and without other individualized patterns from a subject or from other subjects, can increase the accuracy and efficacy of the system for achieving the desired goal.

Abstract: The present invention relates to methods for treating psoriasis and other indications by inhibiting leptin activity.

Abstract: There are provided herein a system and a computer implemented method for preventing, mitigating or treating partial/complete loss of effect of one or more drugs or medical devices administered to or used by a subject in need thereof due to adaptation, tolerance, and/or tachyphylaxis, and/or for preventing, mitigating or treating non-responsiveness to one or more drugs, maximizing therapeutic effect of one or more drugs, or for improving target or non-target organ/organs response to therapy, the system/method include (processing circuit configured to): receiving a plurality of physiological or pathological parameters of the subject; applying a machine learning algorithm on the plurality of physiological or pathological parameters; and determining a subject-specific administration regimen of a drug or a medical treatment, wherein the administration regimen comprises drug administration parameters, cell/tissue/organ stimulation parameters, adjuvant parameters or any combination thereof; wherein the administratio

Abstract: The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects. This method comprises the administration of a naturally occurring, mammalian intermediary metabolite or T cell receptor ligand, preferably a glucosylceramide, to a mammalian subject. In a preferred embodiment, such mammalian subjects are human beings.