Patents by Inventor Yaron Shmuely

Yaron Shmuely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of 9-hydroxy risperidone (paliperidone)
    Patent number: 7915412
    Abstract: The present invention relates to a process for preparing paliperidone from its intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: March 29, 2011
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Santiago Ini, Naama Chasid, Yaron Shmuely, Kobi Chen
  • Process for the synthesis of CMHTP and intermediates thereof
    Patent number: 7820816
    Abstract: The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone. The present invention also provides processes for preparing these intermediates and for preparing paliperidone.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: October 26, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ben-Zion Dolitzky, Evgeny Shapiro, Santiago Ini, Yaron Shmuely, Eli Lancry
  • Processes for the preparation and purification of paliperidone palmitate
    Publication number: 20090209757
    Abstract: The present invention encompasses processes for the preparation and purification of paliperidone palmitate.
    Type: Application
    Filed: January 12, 2009
    Publication date: August 20, 2009
    Inventors: Santiago Ini, Yaron Shmuely, Osnat Porter-Kleks, Kobi Chen, Eli Lancry, Claude Singer
  • Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate
    Patent number: 7560573
    Abstract: A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: July 14, 2009
    Assignee: Teva Pharmaceutical Industries Ltd
    Inventors: Santiago Ini, Yaron Shmuely, Mili Abramov
  • Processes for preparing solid states of O-desmethylvenlafaxine succinate
    Publication number: 20080234516
    Abstract: Provided are processes for the preparation of amorphous O-desmethylvenlafaxine and for the preparation of crystalline forms I, II, III, and IV of O-desmethylvenlafaxine.
    Type: Application
    Filed: March 14, 2008
    Publication date: September 25, 2008
    Inventors: Valerie Niddam-Hildesheim, Sharona Shachan-Tov, Yaron Shmuely, Tamar Nidam, Alexandr Jegorov
  • Process for the synthesis of CMHTP and intermediates thereof
    Publication number: 20080214809
    Abstract: The present invention provides processes of preparing 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone, wherein the processes use 3-(2-chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMBP) and/or 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) having phosphorus at least partially removed as the intermediate.
    Type: Application
    Filed: February 27, 2008
    Publication date: September 4, 2008
    Inventors: Ben-Zion Dolitzky, Evgeny Shapiro, Santiago Ini, Yaron Shmuely, Eli Lancry, Gideon Pilarsky
  • Process for the synthesis of CMHTP and intermediates thereof
    Publication number: 20080200676
    Abstract: The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]- pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone. The present invention also provides processes for preparing these intermediates and for preparing paliperidone.
    Type: Application
    Filed: August 23, 2007
    Publication date: August 21, 2008
    Inventors: Ben-Zion Dolitzky, Evgeny Shapiro, Santiago Ini, Yaron Shmuely, Eli Lancry
  • Crystal forms of 9-hydroxy-risperidone (paliperidone)
    Publication number: 20080177067
    Abstract: The present invention provides amorphous and crystalline forms of Paliperidone, and processes for preparing thereof.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 24, 2008
    Inventors: Ben-Zion Dolitzky, Santiago Ini, Naama Chasid, Yaron Shmuely, Kobi Chen, Eli Lancry
  • Process for the synthesis of 9-hydroxy risperidone (paliperidone)
    Publication number: 20080171875
    Abstract: The present invention relates to a process for preparing paliperidone from its intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 17, 2008
    Inventors: Santiago Ini, Naama Chasid, Yaron Shmuely, Kobi Chen
  • Process for the preparation of optically active (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
    Publication number: 20080015362
    Abstract: Duloxetine intermediates, processes for their preparation, and their conversion to pharmaceutically acceptable salts of duloxetine are described.
    Type: Application
    Filed: April 17, 2007
    Publication date: January 17, 2008
    Inventors: Santiago Ini, Yaron Shmuely
  • Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate
    Publication number: 20080015363
    Abstract: A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided.
    Type: Application
    Filed: February 21, 2007
    Publication date: January 17, 2008
    Inventors: Santiago Ini, Yaron Shmuely, Mili Abramov
  • Process for the preparation of(s)-(+)-N,N-dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)propanamine, A duloxetine intermediate
    Publication number: 20070238883
    Abstract: Provided is a process for preparing a duloxetine intermediate, (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine (DNT), and its conversion to duloxetine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 11, 2007
    Inventors: Santiago Ini, Yaron Shmuely, Mili Abramov