Abstract: Provided are a preparation method for a tumor-infiltrating lymphocyte, and use thereof, particularly relating to a method for culturing a tumor-infiltrating lymphocyte, comprising: subjecting a TIL, which is derived from tumor tissues and not expanded in vitro, to in vitro expansion of at least one stage, and wherein the TIL is contacted with a CD28 agonist in the in vitro expansion of at least one stage. Further provided is a method for preventing and/or treating tumors by using the tumor-infiltrating lymphocyte.

Abstract: A method for culturing tumor infiltrating lymphocytes (TIL), the method comprising co-culturing the expanded TIL with feeder cells after contacting the TIL with a T cell co-stimulatory molecule and/or a T cell growth factor for a period of time. In addition, further provided is a method for preventing and/or treating tumors by means of using the tumor infiltrating lymphocytes of the present application.

Abstract: A device and method for geo-electric extraction under water layer coverage are provided. The device includes auxiliary tubes, outer casings, main tubes, mud extractors, encapsulated extraction electrodes and a fixing ferrule assembly, where the auxiliary tubes each have one end open and the other end closed; the outer casings each have one end open and the other end detachably connected to a top cover; an inner diameter of each of the outer casings is larger than an outer diameter of each of the auxiliary tubes; an outer diameter of each of the main tubes is smaller than the inner diameter of each of the outer casings; the mud extractors each include an inner rod, an outer rod and a bottom plate; the outer rod is sleeved outside the inner rod; the inner rod has one end provided with a dredging wheel and the other end provided with a handle.

Abstract: The disclosure relates to a BCMA-targeting chimeric antigen receptor and uses thereof. Specifically, the disclosure provides a polynucleotide sequence selected from the group consisting of: (1) a polynucleotide sequence comprising, linked in sequence, a sequence encoding an anti-BCMA single chain antibody, a sequence encoding the hinge region of human CD8?, a sequence encoding the transmembrane region of human CD8, a sequence encoding the intracellular domain of human 41BB, a sequence encoding the intracellular domain of human CD3? and optionally a sequence encoding a fragment of EGFR comprising the extracellular domain III and the extracellular domain IV; and (2) a complementary sequence of the polynucleotide sequence of (1). The disclosure further provides corresponding fusion proteins and vectors comprising the coding sequence, as well as uses of the fusion proteins, coding sequences and vectors.

Abstract: A liposome composition that is useful for treating a subject in need of cancer treatment includes a cross-linked multilamellar liposome having an exterior surface and an interior surface. The interior surface defines a central liposomal cavity. The multilamellar liposome includes at least a first lipid bilayer and a second lipid bilayer. The first lipid bilayer is covalently bonded to the second lipid bilayer. At least one anticancer compound is disposed within the multilamellar liposome. Methods for treating subjects are also provided.