Abstract: Systems and method to affect anatomical structures is disclosed. The systems and method can be used to regenerate bone. The system can comprise a nanofiber mesh configured to substantially conform to an anatomical structure, wherein at least a portion of the nanofiber mesh defines a fillable space. The system can comprise a carrier substance comprising an active agent, such as a bone morphogenetic protein, The carrier substance can be disposed within the fillable space.

Abstract: The various embodiments of the present invention are generally directed to systems and methods to affect anatomical structures. More particularly, the various embodiments of the present invention are directed to systems and methods to regenerate bone. An aspect of the present invention comprises a system for affecting an anatomical structure, comprising: a nanofiber mesh configured to substantially conform to an anatomical structure, wherein at least a portion of the nanofiber mesh defines a fillable space; a carrier substance comprising an active agent, such as a bone morphogenetic protein, wherein the carrier substance is disposed within the fillable space.