Patents by Inventor Yashoraj Rupsinh Zala
Yashoraj Rupsinh Zala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8187633Abstract: The present invention relates to a tablet composed of a core and a coating; said core is formed by two or more layers, wherein at least one of them contains an active agent (3). Wherein one of said layers is formulated as a swellable composition (2), the other one (4) is composed of inert compounds retaining its size at least until the coated tablet is emptied from the stomach. The coating composition is selected from the group comprising water insoluble polymers, ph dependent polymers or mixtures thereof. The active agent is released after rupture of the coating.Type: GrantFiled: November 3, 2006Date of Patent: May 29, 2012Assignee: Sun Pharma Advanced Research Company LimitedInventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala
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Patent number: 8163306Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.Type: GrantFiled: June 30, 2004Date of Patent: April 24, 2012Assignee: Sun Pharma Advanced Research CompanyInventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala, Amarjit Singh
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Publication number: 20110250271Abstract: The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus.Type: ApplicationFiled: June 17, 2011Publication date: October 13, 2011Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Dilip Shantilal Shanghvi, Kirti Wardhaman Ganorkar, Yashoraj Rupsinh Zala, Nitin Bhalachandra Dharmadhikari, Satish C. Khanna
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Publication number: 20110207794Abstract: The present invention relates to an oral controlled release pharmaceutical composition in the form of a unit dosage form comprising: (a) a highly soluble high dose active ingredient consisting essentially of therapeutically effective amount of levetiracetam or a pharmaceutically acceptable derivative thereof, and (b) a rate controlling means comprising a rate-controlling agent and/or a coating selected from (i) a active ingredient permeable coating surrounding the unit dosage form, and (ii) an active ingredient impermeable coating covering one or more surfaces but not all the surfaces of the unit dosage form, wherein the composition is in the form of a compact tablet and the levetiracetam or a pharmaceutically acceptable derivative thereof is present in an amount ranging from about 55% to about 90% by weight of the tablet.Type: ApplicationFiled: May 6, 2011Publication date: August 25, 2011Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Yashoraj Rupsinh ZALA, Nitin Bhalachandra DHARMADHIKARI
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Publication number: 20110206767Abstract: The present invention relates to an oral controlled release pharmaceutical composition in the form of a unit dosage form comprising: (a) a highly soluble high dose active ingredient consisting essentially of therapeutically effective amount of levetiracetam or a pharmaceutically acceptable derivative thereof, and (b) a rate controlling means comprising a rate-controlling agent and/or a coating selected from (i) a active ingredient permeable coating surrounding the unit dosage form, and (ii) an active ingredient impermeable coating covering one or more surfaces but not all the surfaces of the unit dosage form, wherein the composition is in the form of a compact tablet and the levetiracetam or a pharmaceutically acceptable derivative thereof is present in an amount ranging from about 55% to about 90% by weight of the tablet.Type: ApplicationFiled: May 6, 2011Publication date: August 25, 2011Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Yashoraj Rupsinh ZALA, Nitin Bhalachandra DHARMADHIKARI
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Publication number: 20110200671Abstract: The present invention discloses a method of treating a disease condition susceptible to baclofen therapy, said method comprising orally administering once-a-day in the evening a controlled release drug delivery system comprising baclofen or its pharmaceutically acceptable salt or its derivatives and pharmaceutically acceptable excipients.Type: ApplicationFiled: February 17, 2011Publication date: August 18, 2011Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Nitin Bhalachandra DHARMADHIKARI, Yashoraj Rupsinh Zala
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Patent number: 7964216Abstract: The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus.Type: GrantFiled: January 11, 2002Date of Patent: June 21, 2011Assignee: Sun Pharma Advanced Research Company LimitedInventors: Dilip Shantilal Shanghvi, Kirti Wardhaman Ganorkar, Yashoraj Rupsinh Zala, Nitin Bhalachandra Dharmadhikari, Satish C Khanna
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Publication number: 20090208572Abstract: A method of reducing the risk of alcohol-induced dose-dumping of a therapeutically active ingredient comprising administering to human subjects who have ingested alcohol an oral controlled release tablet; said tablet comprising: a core comprising an upper compressed layer comprising a swelling agent, and a lower compressed layer comprising at least one therapeutically active ingredient, and pharmaceutically acceptable excipient wherein at least one excipient is a release rate controlling excipient and wherein the percent by weight of excipients that are soluble in alcohol does not exceed 35% by weight of the layer and; a coating surrounding the said core, the coating comprising a polymer insoluble in an aqueous medium comprising from 0% v/v to 40% v/v of alcohol, whereby upon contact with aqueous gastrointestinal fluids, the upper compressed layer swells to cause removal of the coating from the upper surface of the upper compressed layer and then said upper layer disintegrates allowing the release of thType: ApplicationFiled: February 17, 2009Publication date: August 20, 2009Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala
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Publication number: 20090123541Abstract: The present invention relates to an oral controlled release pharmaceutical composition in the form of a unit dosage form comprising: (a) a highly soluble high dose active ingredient consisting essentially of therapeutically effective amount of levetiracetam or a pharmaceutically acceptable derivative thereof, and (b) a rate controlling means comprising a rate-controlling agent and/or a coating selected from (i) a active ingredient permeable coating surrounding the unit dosage form, and (ii) an active ingredient impermeable coating covering one or more surfaces but not all the surfaces of the unit dosage form, wherein the composition is in the form of a compact tablet and the levetiracetam or a pharmaceutically acceptable derivative thereof is present in an amount ranging from about 55% to about 90% by weight of the tablet.Type: ApplicationFiled: February 22, 2006Publication date: May 14, 2009Applicant: Sun Pharmaceutical Industries LimitedInventors: Yashoraj Rupsinh Zala, Nitin Bhalachandra Dharmadhikari
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Publication number: 20080241238Abstract: The present invention relates to a tablet composed of a core and a coating; said core is formed by two or more layers, wherein at least one of them contains an active agent (3). Wherein one of said layers is formulated as a swellable composition (2), the other one (4) is composed of inert compounds retaining its size at least until the coated tablet is emptied from the stomach. The coating composition is selected from the group comprising water insoluble polymers, ph dependent polymers or mixtures thereof. The active agent is released after rupture of the coating.Type: ApplicationFiled: November 3, 2006Publication date: October 2, 2008Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala
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Publication number: 20080213381Abstract: The present invention provides an oral drug delivery system comprising— a. a core comprising an active ingredient composition comprising therapeutically effective amount of at least one active ingredient and a pharmaceutically acceptable excipient, and b. a coating surrounding the core, said coating comprising a water-insoluble polymer and a pH-dependent polymer, wherein the oral drug delivery system is in the form of a coated tablet and includes a feature such that after a predetermined delay the coating is reliably removed fully or partially from one or more of the tablet surfaces upon contact with intestinal fluids, further wherein the feature is that the core further comprises a composition selected from a swellable composition and a reactive composition located in the immediate vicinity of one or more preselected surfaces from which the coating is desired to be fully or partially removed, wherein the coating is not removed from at least one of the surfaces.Type: ApplicationFiled: March 14, 2006Publication date: September 4, 2008Applicant: PHARMACEUTICAL INDUSTRIES LIMITEDInventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala
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Publication number: 20080138410Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating comprising water insoluble polymer(s) and leachable component(s) is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.Type: ApplicationFiled: November 28, 2007Publication date: June 12, 2008Applicant: SUN PHARMACEUTICAL INDUSTRIES LIMITEDInventors: Nitin Bhalachandra DHARMADHIKARI, Yashoraj Rupsinh Zala, Amarjit Singh
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Publication number: 20080107732Abstract: The present invention provides a novel gastric retention system in the form of a tablet or a capsule coated with an expandable coating, more particularly, with an expandable coating comprising a film-forming polymer and an expandable component.Type: ApplicationFiled: March 24, 2005Publication date: May 8, 2008Inventors: Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala
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Publication number: 20040156900Abstract: The present invention provides a timed pulse release composition comprising: a. a core composition comprising a therapeutically active agent, a swelling agent, and optionally water soluble compound(s) for inducing osmosis, and b. a coat composition comprising one or more film forming polymers, wherein upon imbibing fluid from the surrounding the core swells, and the coat ruptures to release in a pulse, the therapeutically active agent in a reliable manner at about a predetermined time wherein the reliable manner of rupture comprises rupturing of 36 tablets out of a total of 36 tablets at about the predetermined time when tested by subjecting the tablets to USP dissolution test using an aqueous media at 37±0.5oC, in a USP Type I or Type II apparatus at an rpm selected from the range of about 50 rpm to about 100 rpm.Type: ApplicationFiled: October 9, 2003Publication date: August 12, 2004Inventors: Dilip Shantilal Shanghvi, Nitin Bhalachandra Dharmadhikari, Yashoraj Rupsinh Zala, Satish C. Khanna
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Publication number: 20040086562Abstract: The present invention provides to a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system, wherein the time of release of the two or more therapeutically active agents is designed to provide desired control on the disease condition. The present invention also provides a method of administration of two or more therapeutically active agents comprising orally administering to a patient a spaced drug delivery system at a specified time prior to food intake by the patient. The present invention further provides a spaced drug delivery system that releases two or more antidiabetic agents at different times after oral administration, for the treatment of diabetes mellitus or conditions associated with diabetes mellitus.Type: ApplicationFiled: November 17, 2003Publication date: May 6, 2004Inventors: Dilip Shantilal Shanghvi, Kirti Wardhaman Ganorkar, Yashoraj Rupsinh Zala, Nitin Bhalachandra Dharmadhikari, Satish C. Khanna