Patents by Inventor Yasmeen Abouelhassan
Yasmeen Abouelhassan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11419335Abstract: The present invention provides novel compounds of Formula (I?) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and/or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and/or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and/or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).Type: GrantFiled: December 7, 2017Date of Patent: August 23, 2022Assignee: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Yasmeen Abouelhassan, Akash Basak
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Patent number: 11053205Abstract: The present invention provides novel phenazine derivatives, such as compounds of Formula (I) (e.g., Formulae (II)-(XIX)), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.Type: GrantFiled: February 17, 2018Date of Patent: July 6, 2021Assignee: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Aaron Garrison, Yasmeen Abouelhassan, Hongfen Yang, Gena Burch
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Patent number: 11008290Abstract: The present invention provides halogenated quinoline derivatives, such as compounds of Formula (I) or (I?), and pharmaceutically acceptable salts thereof, and methods of preparing the halogenated quinoline derivatives. The halogenated quinoline derivatives are expected to be antimicrobial agents and may act through an iron(II)-dependent mode of action. The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the halogenated quinoline derivatives and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium), killing a microorganism (e.g., a bacterium), inhibiting the formation and/or growth of a biofilm, reducing or removing a biofilm, and/or disinfecting a surface.Type: GrantFiled: September 23, 2016Date of Patent: May 18, 2021Assignee: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Akash Basak, Yasmeen Abouelhassan
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Publication number: 20200010432Abstract: The present invention provides novel phenazine derivatives, such as compounds of Formula (I) (e.g., Formulae (II)-(XIX)), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.Type: ApplicationFiled: February 17, 2018Publication date: January 9, 2020Applicant: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Aron Garrison, Yasmeen Abouelhassan, Hongfen Yang, Gena Burch
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Publication number: 20190373890Abstract: The present invention provides novel compounds of Formula (I?) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for killing a microorganism (e.g., bacteria, fungi, viruses, protozoa, or multicellular parasites), the prevention and/or treatment of infectious diseases (e.g., infections by microorganisms, bacterial infection, cystic fibrosis infection, foreign body infection, urinary tract infection (UTI), or infections leading to biofilms), controlling and/or eradicating biofilms (e.g., bacterial biofilms), preventing biofilm formation, sterilizing a surface, and/or eradicating persister cells (e.g., in a subject in need thereof or in a subject involving a biofilm).Type: ApplicationFiled: December 7, 2017Publication date: December 12, 2019Applicant: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Yasmeen Abouelhassan, Akash Basak
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Publication number: 20180265475Abstract: The present invention provides halogenated quinoline derivatives, such as compounds of Formula (I) or (I?), and pharmaceutically acceptable salts thereof, and methods of preparing the halogenated quinoline derivatives. The halogenated quinoline derivatives are expected to be antimicrobial agents and may act through an iron(II)-dependent mode of action. The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the halogenated quinoline derivatives and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium), killing a microorganism (e.g., a bacterium), inhibiting the formation and/or growth of a biofilm, reducing or removing a biofilm, and/or disinfecting a surface.Type: ApplicationFiled: September 23, 2016Publication date: September 20, 2018Applicant: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Akash Basak, Yasmeen Abouelhassan