Patents by Inventor Yasong WU

Yasong WU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11530264
    Abstract: A multifunctional polypeptide chain or a protein. A polypeptide chain X, comprising an antigen 1 binding domain R1, an auxiliary peptide chain linking domain R2 and an antigen 2 binding domain R3. The auxiliary peptide chain linking domain R2 is a cytokine or a cytokine binding domain in a cytokine receptor. A protein, which is a heterodimer composed of the polypeptide chain X as a main peptide chain and an auxiliary peptide chain Y. The auxiliary peptide chain Y comprises an antigen 3 binding domain R4 and a main peptide chain X linking domain R5, or the auxiliary peptide chain Y is the main peptide chain linking domain R5. The multifunctional protein mediates specific cell killing by binding to different tumor antigens with the two antigen binding domains of tumor-associated antigens therein. The multifunctional protein can function as a cytokine by introducing a cytokine or a cytokine receptor complex.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: December 20, 2022
    Assignee: SHENZHEN BEIKE BIOTECHNOLOGY CO., LTD
    Inventors: Fengyu Zhang, Bin Gao, Lei Wang, Yasong Wu, Qing Wei
  • Publication number: 20220064289
    Abstract: A multifunctional polypeptide chain or a protein. A polypeptide chain X, comprising an antigen 1 binding domain R1, an auxiliary peptide chain linking domain R2 and an antigen 2 binding domain R3. The auxiliary peptide chain linking domain R2 is a cytokine or a cytokine binding domain in a cytokine receptor. A protein, which is a heterodimer composed of the polypeptide chain X as a main peptide chain and an auxiliary peptide chain Y. The auxiliary peptide chain Y comprises an antigen 3 binding domain R4 and a main peptide chain X linking domain R5, or the auxiliary peptide chain Y is the main peptide chain linking domain R5. The multifunctional protein mediates specific cell killing by binding to different tumor antigens with the two antigen binding domains of tumor-associated antigens therein. The multifunctional protein can function as a cytokine by introducing a cytokine or a cytokine receptor complex.
    Type: Application
    Filed: December 27, 2017
    Publication date: March 3, 2022
    Inventors: Fengyu ZHANG, Bin GAO, Lei WANG, Yasong WU, Qing WEI
  • Publication number: 20220064595
    Abstract: Disclosed in the present invention is a multi-target chimeric antigen receptor. Provided in the present invention is a multi-target chimeric antigen receptor consisting of a main peptide chain and an auxiliary peptide chain; the main peptide chain comprises an antigen binding domain A, an auxiliary peptide chain connecting domain B, a transmembrane domain C and an intracellular signaling domain D; the auxiliary peptide chain comprises a main peptide chain connecting domain F; the antigen binding domain A is a polypeptide having an antigen-binding function; the auxiliary chain connecting domain B and the main peptide connecting domain F are combined with each other; the transmembrane domain C is a transmembrane domain of any membrane-binding protein or a transmembrane protein; and the intracellular signaling domain D comprises a primary signaling region.
    Type: Application
    Filed: December 27, 2017
    Publication date: March 3, 2022
    Inventors: Lei WANG, Bin GAO, Yasong WU, Yuan SI, Dan LV, Qing WEI