Patents by Inventor Yasuaki Ogawa
Yasuaki Ogawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5094854Abstract: This invention relates to the liposome compositions which are characterized in that the phase transition temperature of the membrane is in the range of 40.degree. to 45.degree. C. and the osmotic pressure of a drug-containing solution to be entrapped in liposomes is 1.2 to 2.5 times higher than that of body fluid of warm-blooded animals. The compositions are useful for treatment of solid tumors in hyperthermia therapy.Type: GrantFiled: October 31, 1990Date of Patent: March 10, 1992Assignee: Takeda Chemical Industries, Ltd.Inventors: Yasuaki Ogawa, Katsumi Iga, Yasutaka Igari
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Patent number: 5081756Abstract: Methods are provided for assembling a magnetic encoder wherein fluctuation of a magnetic gap arising from a change in temperature is minimized. The magnetic encoder comprises a magnetic scale having thereon a magnetic pattern which can be detected by a magnetic sensor, a sensor retainer for securely retaining the magnetic sensor with a magnetic gap left between the magnetic scale and the magnetic sensor, and a supporting member to which the sensor retainer is secured.According to the invention, a jig is affixed to a surface of the sensor retainer, and the jig is moved until the gap between the magnetic scale and the magnetic sensor reaches a predetermined width. The sensor retainer may be secured to a supporting member by first and second securing agents, the second securing agent being the harder and applied closer to the magnetic sensor than the first securing agent.Type: GrantFiled: June 7, 1990Date of Patent: January 21, 1992Assignee: Alps Electric Co., Ltd.Inventors: Hiraku Abe, Hidemasa Suzuki, Ichiro Tokunaga, Yasuaki Ogawa
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Patent number: 5080904Abstract: The liposome compositions entrapping a drug are prepared by constituting the liposomal membrane with a saturated phospholipid and a glycolipid having sulfo group. Thus obtained compositions circulate stably in blood for a long time after intravenous administration.Type: GrantFiled: May 10, 1989Date of Patent: January 14, 1992Assignee: Takeda Chemical Industries, Ltd.Inventors: Katsumi Iga, Naoru Hamaguchi, Yasuaki Ogawa
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Patent number: 5061492Abstract: A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.Type: GrantFiled: January 24, 1990Date of Patent: October 29, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki
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Patent number: 5019394Abstract: The liposome compositions entrapping a drug are prepared by constituting the liposomal membrane with saturated phospholipids and anionic surfactants of high Krafft point at concentrations above their critical micelle concentrations. Thus obtained compositions circulate stably in blood for a long time after intravenous administration.Type: GrantFiled: February 24, 1988Date of Patent: May 28, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Naoru Hamaguchi, Katsumi Iga, Yasuaki Ogawa
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Patent number: 5000959Abstract: The liposome compositions entrapping a drug are prepared by constituting the liposomal membrane with a saturated phospholipid and a glycolipid having sialic acid group. Thus obtained compositions circulate stably in blood for a long time after intravenous administration.Type: GrantFiled: May 10, 1989Date of Patent: March 19, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Katsumi Iga, Naoru Hamaguchi, Yasuaki Ogawa
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Patent number: 4959574Abstract: A magnetic rotary encoder device wherein fluctuation of a magnetic gap arising from a change in temperature is minimized, a printed circuit board on which an electric circuit electrically connected to a magnetic sensor is carried can be assembled readily, and a magnetic gap can be adjusted readily. The magnetic encoder device comprises a magnetic scale having thereon a magnetic code which can be detected by a magnetic sensor, a retaining member for securely retaining the magnetic sensor on a sensor mounting element with a magnetic gap left between the magnetic scale and the magnetic sensor, and a supporting member to which the retaining member is secured. A first bonding agent and a second, softer bonding agent secure the supporting member and portions of the sensor mounting element adjacent and remote from the supporting member to each other, respectively.Type: GrantFiled: March 31, 1989Date of Patent: September 25, 1990Assignee: Alps Electric Co., Ltd.Inventors: Hidemasa Suzuki, Ichiro Tokunaga, Hiraku Abe, Yasuaki Ogawa
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Patent number: 4954298Abstract: Microcapsules are advantageously produced with high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a polymer-containing solution as the oil phase, dispersing said emulsion in an aqueous phase and subjecting the resulting W/O/W emulsion to an in-water drying, wherein the viscosity of the W/O emulsion used in preparing the W/O/W emulsion is adjusted to about 150 to about 10,000 centipoises.Type: GrantFiled: September 23, 1988Date of Patent: September 4, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Masaki Yamamoto, Shigeyuki Takada, Yasuaki Ogawa
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Patent number: 4917893Abstract: A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.Type: GrantFiled: September 30, 1987Date of Patent: April 17, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki
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Patent number: 4877561Abstract: Liposomes with an increased drug trap can be prepared by adding a readily volatile organic solvent to a drug-containing liquid with liposomes dispersed therein to cause gel formation and then removing said organic solvent by evaporation.Type: GrantFiled: April 2, 1987Date of Patent: October 31, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Katsumi Iga, Naoru Hamaguchi, Yasuaki Ogawa
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Patent number: 4849228Abstract: The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an exipient for pharmaceutical preparations.Type: GrantFiled: November 6, 1987Date of Patent: July 18, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Masaki Yamamoto, Hiroaki Okada, Yasuaki Ogawa, Tsutomu Miyagawa
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Patent number: 4844904Abstract: Liposome compositions in which a drug is retained in stable condition are prepared by dispersing liposomes obtained by removal of a solvent from a drug-containing w/o emulsion in an aqueous solution having an osmotic pressure higher by at least 20 percent than the osmotic pressure of a solution used for entrapping the drug in said liposomes. This composition is conducive to a sustained therapeutic efficacy or a better delivery of the drug to a target organ.Type: GrantFiled: November 21, 1986Date of Patent: July 4, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Naoru Hamaguchi, Katsumi Iga, Yasuaki Ogawa
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Patent number: 4728721Abstract: The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.The thus-obtained molecular polymer has good aging stability and can be used advantageously as an excipient for pharmaceutical preparations.Type: GrantFiled: May 1, 1986Date of Patent: March 1, 1988Assignees: Takeda Chemical Industries, Ltd., Wako Pure Chemical Industries, Ltd.Inventors: Masaki Yamamoto, Hiroaki Okada, Yasuaki Ogawa, Tsutomu Miyagawa
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Patent number: 4711782Abstract: A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.Type: GrantFiled: December 11, 1986Date of Patent: December 8, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki
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Patent number: 4683288Abstract: A polymer or copolymer of lactic acid and/or glycolic acid which has a weight-average molecular weight of not less than about 5,000 and a dispersity of about 1.5 to 2 is advantageously used as a biodegradable polymer or copolymer for medical preparation.Type: GrantFiled: July 3, 1985Date of Patent: July 28, 1987Assignees: Waco Pure Chemical Ind. Inc., Takeda Chemical Industries, Ltd.Inventors: Motoaki Tanaka, Yasuaki Ogawa, Tsutomu Miyagawa, Toshio Watanabe
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Patent number: 4677191Abstract: A copolymer of lactic acid and glycolic acid which has a weight-average molecular weight of not less than about 5000 and a dispersity of about 1.5 to 2 is advantageously used as a biodegradable polymer for medical preparation.Type: GrantFiled: July 3, 1985Date of Patent: June 30, 1987Assignees: Wada Pure Chemical Ind., Ltd., Takeda Chemical Industries, Ltd.Inventors: Motoaki Tanaka, Yasuaki Ogawa, Tsutomu Miyagawa, Toshio Watanabe
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Patent number: 4652441Abstract: A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.Type: GrantFiled: November 1, 1984Date of Patent: March 24, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki
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Patent number: 4572832Abstract: A soft buccal containing (1) a medicament to be absorbed through the oral mucosa, (2) a water-soluble protein, (3) a polyhydric alcohol, and (4) a fatty acid ester or/and a carboxyvinyl polymer, has various advantages such as good feeling in use, good retainability within the mouth, slow release, improved absorbability of drug through the mucosa, improved bioavailability, etc., and therefore can be used an excellent pharmaceutical preparation for administration to the mucous membrane of the mouth.Type: GrantFiled: October 7, 1983Date of Patent: February 25, 1986Assignee: Grelan Pharmaceutical Co., Ltd.Inventors: Kazuo Kigasawa, Hiroaki Shimizu, Toshihiro Hayashi, Kazuo Watabe, Akira Tanizaki, Osamu Koyama, Kikuo Wakisaka, Yasuaki Ogawa
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Patent number: 4283389Abstract: A novel antibiotic designated BN-183B substance is disclosed which is produced by cultivating a strain of the genus Pseudomonas. The antibiotic has a strong action against Gram-positive and Gram-negative bacteria.Type: GrantFiled: December 19, 1979Date of Patent: August 11, 1981Assignee: Meiji Seika Kaisha Ltd.Inventors: Norio Ezaki, Shinji Miyadoh, Yasuaki Ogawa, Takashi Hisamatsu, Harumi Fukuyashu, Yujiro Yamada
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Patent number: 4220639Abstract: New antibiotics, SF-2050 substance and SF-2050B substance are produced by cultivating a microorganism Streptomyces sp. SF-2050 now deposited under FERM-P 4358 and under ATCC. 31450 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and useful as an antibacterial agent. These antibiotics have an activity inhibitory to .beta.-lactamase.Type: GrantFiled: January 26, 1979Date of Patent: September 2, 1980Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazunori Ohba, Chuhei Nojiri, Yasuaki Ogawa, Jiro Itoh, Kunikazu Totsugawa, Norio Ezaki, Takashi Shomura, Tomizo Niwa, Shigeharu Inouye, Yujiro Yamada