Abstract: Proliferation of cancer cells is effectively inhibited. Provided is a cancer cell-inhibiting ceramic containing a ?-tricalcium phosphate porous granule with a particle size of 1 to 10 ?m. The ?-tricalcium phosphate porous granule is taken up into cancer cells at an affected area and have an effect of inhibiting proliferation of a cancer tissue. The ?-tricalcium phosphate porous granule with a particle size of 1 to 10 ?m can be used to more effectively inhibit the proliferation of the cancer cells.

Abstract: There are provided a body tissue filling material having excellent engraftability and repairability, and a method for producing such a body tissue filling material in a simple manner. Specifically disclosed are: a body tissue filling material comprising a gelatin porous carrier, to the surface of which a coating having sulfated hyaluronic acid is applied; and a method for producing a body tissue filling material, comprising: a step (S3) of adding dropwise a sulfated hyaluronic acid solution to a gelatin porous carrier to effect impregnation thereof; a step (S4) of freezing the porous carrier impregnated with the sulfated hyaluronic acid solution; and a step (S5) of drying the frozen porous carrier.

Abstract: A method of producing a biological tissue-reinforcing material, which is applicable to a site required to be reinforced and which enables to improve the working properties for transplantation, comprising the step S1 of coprecipitating ammonium hydrogen phosphate with calcium nitrate in the presence of sulfuric acid.

Abstract: The present invention discloses a cell culturing system that cultures predetermined cells collected from a patient and supplies cultured cells to the original patient, which together with enabling correlations between the cultured cells and the supplier of the cells to be managed accurately and easily at all times, allows cultured cells and patients to be collated rapidly.

Abstract: A bone substitute (a material for repairing biological tissues) made from ?-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue.

Abstract: An object is to promote the growth of adhered cells and improve adhesiveness of stem cells. A cylindrical scaffold made of a porous calcium phosphate (for example, beta-TCP) material has a form in which a plurality of through-holes extending in a single direction are separated from each other by partition wall members having an almost uniform thickness. The material for repairing biological tissues wherein each through-hole has a quadrangular shape, and each partition wall member has a plurality of concavities and a plurality of pores in the surface, and a process for producing the same are provided.

Abstract: A bone substitute (a material for repairing biological tissues) made from ?-TCP as the raw material comprises a plate-type base member on the surface of which a plurality of grooves extending in a single direction are formed and separated from each other by partition wall members having an almost uniform thickness. This material sustains a sufficient binding force after application to a biological tissue and exhibits an excellent effect of forming a biological tissue.

Abstract: Osteoblast activity is promoted and a large amount of extracellular substrates are produced so as to promote cell proliferation and/or differentiation. A material for repairing biological tissues, the material comprising a biocompatible material containing at least one of niobium and tantalum, is provided. These metal salts are not toxic even at high concentrations, and can activate osteoblasts to increase the production quantity of extracellular substrates. The material for repairing biological tissues is manufactured by mixing a metal salt solution, a calcium compound, and a phosphate compound (S4), then coprecipitating the metal-containing calcium phosphate.

Abstract: The present invention discloses a cell culturing system that cultures predetermined cells collected from a patient and supplies cultured cells to the original patient, which together with enabling correlations between the cultured cells and the supplier of the cells to be managed accurately and easily at all times, allows cultured cells and patients to be collated rapidly. In a cell culturing system 20 that carries in cells containing stem cells and contains them in an incoming transport container to which is attached unique identification information, transfers the transported cells to and cultures them in a culture container to which is attached unique identification information, and carries out the cultured cells by transferring them to an outgoing transport container to which is attached unique identification information, ID numbers attached to the containers before and after transfer are input from a barcode reader 31 whenever the cells are transferred to a different container.

Abstract: An improved porous ceramic body to be embedded in a patient for sustained release of a medicament, and a method of making the ceramic body is provided. To control the release of the medicament, the pores of the ceramic body decrease in diameter from the inner surface to the outer surface of the body whereby the pore diameter is substantially proportional to the distance from the outer surface of the carrier. First, raw ceramic slurry is made from the blend of &bgr;-TCP, deflocculating agent, and water. Next, using a syringe the ceramic slurry is supplied to the internal region of a solvent-absorbable mold from an aperture along the inner wall surface. Then, the ceramic slurry is quickly dehydrated before thinly adhering itself onto the inner wall surface of the mold. Therefore, a preformed body having a hollow is obtained. Next, after fully being dried, the dried preformed body is fired at 1,050° C. for an hour before eventually yielding a spherical carrier for use in sustained release preparation.

Abstract: A plasminogen activator such as urokinase or tissue plasminogen activator is covalently bonded to a porous body composed of calcium phosphate to form a plasminogen activator-porous body complex. The tricalcium phosphate can be .alpha.-tricalcium phosphate, .beta.-tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, octacalcium phosphate and mixtures thereof. In a preferred embodiment, .beta.-tricalcium phosphate which has excellent biocompatibility with the body or a mixture of .beta.-tricalcium phosphate and hydroxyapatite is used. Preferably, synthetic calcium phosphate is used is to avoid impurities contained by natural calcium phosphate. Covalent bonding is by crosslinking with glutaraldehyde, bismaleimides, dihalogenic aryls or diisocyanates, or by using cyanogen bromide, diazotization or periodic acid. The complex can be filled into a column to form a bioreactor.

Abstract: A wax pattern is built up on the surface of the other end of a post comprising pure titanium. The wax pattern is used to produce a casting mold. While the casting mold is kept at a predetermined temperature, a crystallized glass having a thermal expansion coefficient falling within the range of .+-.5.times.10.sup.-7 with respect to that of pure titanium is melted and cast in the mold. The resultant mold product is heated and crystallized to obtain a dental prosthesis. A post comprising pure titanium is chemically bonded to a core comprising the crystallized glass. This invention provides a dental prosthesis which is easy to manufacture and nontoxic to the human body.

Abstract: Powdery calcium carbonate and a powdery dihydrate of calcium monohydrogenohosphate are weighed to get a Ca/P ratio of 1.45 to 1.67. The powdery mixture thus prepared is then added pure water at a temperature of 30.degree. C. or higher to obtain an aqueous slurry having a concentration of about 10% by weight. Thereafter, the aqueous slurry is subjected to a rotational attrition by using a ball mill to conduct a mechanochemical reaction of the calcium carbonate with the dihydrate of calcium monohydrogenphosphate. The slurry is then dried completely at 80.degree. C., followed by pulverization to yield a dry powder of calcium phosphate hydrate. The dry powder is calcinated at a temperature ranging from 720.degree. to 1,150.degree. C. for 1-10 hours or more to give calcium phosphate powder, which is molded in a desired shape and is sintered at a certain temperature to obtain a sintered body of calcium phosphate.

Abstract: A drug-impregnated ceramic to be embedded in a living body is disclosed, and includes a porous ceramic having pores with a pore size of 10 to 300 .mu.m, a drug impregnating the porous ceramic via the pores, and a surface layer for controlling the release of the drug. The surface layer is formed to cover at least a portion of the outer surface of the porous ceramic and has a porosity lower than that of the porous ceramic.

Abstract: A sustained release material to be buried at a position close to a diseased part in a living body to slowly release an impregnated liquid drug includes a core mainly consisting of a ceramic material and having a plurality of pores formed at a predetermined porosity, and a surface layer mainly consisting of a ceramic material, formed around the outer surface of the core, and having a plurality of pores having a pore size or porosity smaller than that of the pores formed in the core.

Abstract: A prosthetic artificial bone having a double-layered structure obtained by forming a high porosity portion having a porosity of from 40 to 90% and a lower porosity portion having a porosity of 50% or less, into an integral body, and wherein the high porosity portion and the lower porosity portion each comprise a ceramics containing calcium and phosphorus.

Abstract: A ceramic member for a living body includes a first end portion formed of a material having affinity with a living body and consisting of a dense material, and a second end portion formed of a material having affinity with a living body and consisting of a porous material.