Patents by Inventor Yasuharu Noishiki

Yasuharu Noishiki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130230638
    Abstract: A medical material for in vivo implantation contains a bioabsorbable material containing a softening agent and/or a moisturizing agent and a non-bioabsorbable porous base material, in which the content of a softening agent and/or a moisturizing agent is controlled less than 20 wt %; a method for controlling this content; and a method for producing a medical material for in vivo implantation are provided.
    Type: Application
    Filed: March 18, 2013
    Publication date: September 5, 2013
    Inventor: Yasuharu NOISHIKI
  • Publication number: 20120226344
    Abstract: Provided is a stent graft that has superior prevention of endoleakage due to being resistant to creasing, and has superior prevention of graft migration as a result of promoting cell infiltration into gaps among microfibers in a dispersed state and forming an integrated structure with the cells in the landing zone of the stent. The stent graft according to the present invention is a stent graft comprising a stent graft fabric that has microfiber bundles consisting essentially of microfilaments having a filament linear density of 0.5 dtex or less, and said microfiber bundles having a total linear density of 10 to 60 dtex/120 to 3000 filaments, for the warp and/or weft, and in which the porosity of the microfiber bundles is 30% to 95%, wherein said stent graft has said stent graft fabric being located in at least 1 cm range from the central end.
    Type: Application
    Filed: January 24, 2012
    Publication date: September 6, 2012
    Applicants: NOI LAB INC., ASAHI KASEI KURARAY MEDICAL CO., LTD.
    Inventors: Junichi SHIROKAZE, Yasuharu NOISHIKI
  • Publication number: 20120004673
    Abstract: Provided are a medical material for in vivo implantation which causes no retention of an exudates in the surroundings and yet shows a flexibility; a method for controlling the content of a softening agent and/or a moisturizing agent in the medical material; and a method for producing the medical material for in vivo implantation. When a hybrid medical material for in vivo implantation, which comprises a bioabsorbable material containing a softening agent and/or a moisturizing agent and a non-bioabsorbable porous base material, contains large amount of the softening agent and/or a moisturizing agent, retention of an exudates occurs in the surroundings of the medical material. It is found out that this phenomenon is a side effect of the softening agent and/or a moisturizing agent.
    Type: Application
    Filed: March 3, 2010
    Publication date: January 5, 2012
    Inventor: Yasuharu Noishiki
  • Patent number: 7833148
    Abstract: The present invention discloses a fistula formation-inducing material having a property of forming a fistula wherein cells are exposed on at least a portion of the fistula luminal surface. This material can be inserted into a living body, using a hollow tubular member, as desired. As a result, there is provided a fistula formation-inducing material which allows the formation of a fistula, reliably lined by host cells, in a living body.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: November 16, 2010
    Inventor: Yasuharu Noishiki
  • Publication number: 20100030105
    Abstract: [Problems] To provide a double needle enabling easy centesis in bones and cortex and easy alignment of an inner needle with an outer needle in an angular direction and capable of transmitting torque when the inner needle and the outer needle are rotated simultaneously. [Means for Solving Problems] This double needle (10) for medical treatment comprises the cylindrical outer needle (11) having an edge part (26) at its tip and the solid inner needle (12) detachably stored in the outer needle. When the outer needle (11) is rotated about its major axis, the rotating diameter of the edge part (26) is larger than the rotating diameter of a body part. Also, the double needle comprises a corotation mechanism (20) for the outer needle (11) and the inner needle (12).
    Type: Application
    Filed: March 26, 2006
    Publication date: February 4, 2010
    Applicants: HI-LEX CORPORATION
    Inventors: Yasuharu Noishiki, Yasuhiro Fujita, Akihiro Ametani, Yasuo Seki
  • Publication number: 20090215009
    Abstract: [Problems] To provide a medical material having such a structure that enables even diffusion and distribution in the material of a sufficient amount a substance necessary for a medical treatment. [Means for Solving Problems] A medical material 10 composed of a porous three-dimensional construct 11, which is a rectangular parallelepiped having a porosity of from 20 to 97% and pores 12, 13, 14 and 15 provided in the main body. From this pore 12, a substance such as calcium phosphate or ceramics apatite and/or a physiologically active cell, tissue or protein and a substance suitable for exerting the functions thereof are introduced.
    Type: Application
    Filed: February 23, 2006
    Publication date: August 27, 2009
    Applicant: HI-LEX CORPORATION
    Inventors: Yasuharu Noishiki, Yoshinori Kuboki, Yasuo Seki, Hiroyuki Shiota
  • Publication number: 20090187116
    Abstract: Using a bended puncturing needle, a through hole from the greater trochanter of a long tubular bone to the bone marrow cavity is formed, the catheter 61a, 61b is passed into the through hole, a physiological salt solution is injected from one of the catheter 61b, and the physiological salt solution and the bone marrow is stirred by the stirring wire 68, the obtained mixed liquid is aspirated and harvested by another catheter 61a, thereby a large amount of the bone marrow is harvested. A method enabling easy and a large amount harvesting of the bone marrow from long tubular bones such as femurs, in which a multi-lumen catheter can also be used as a catheter.
    Type: Application
    Filed: April 5, 2005
    Publication date: July 23, 2009
    Inventors: Yasuharu Noishiki, Yasuhiro Fujita, Akihiro Ametani, Yasuo Seki
  • Publication number: 20050084511
    Abstract: The present invention discloses a fistula formation-inducing material having a property of forming a fistula wherein cells are exposed on at least a portion of the fistula luminal surface. This material can be inserted into a living body, using a hollow tubular member, as desired. As a result, there is provided a fistula formation-inducing material which allows the formation of a fistula, reliably lined by host cells, in a living body.
    Type: Application
    Filed: December 13, 2002
    Publication date: April 21, 2005
    Inventor: Yasuharu Noishiki
  • Publication number: 20040172061
    Abstract: A tissue or organ regeneration material which can easily be placed in a necrotic area or defective space of a tissue or organ in a living body, while suppressing an excessive growth of fibroblasts, to thereby effectively regenerate an intended tissue or organ, and a method of regenerating a tissue or organ by using the above material. The tissue or organ regeneration material wherein fibroblasts shows substantially no growing property in a gel based on the hydrogel-forming polymer is constituted by using a hydrogel-forming polymer, an aqueous solution of which shows a thermo-reversible sol-gel transition such that it assumes a sol state at a lower temperature and assumes a gel state at a higher temperature.
    Type: Application
    Filed: January 13, 2004
    Publication date: September 2, 2004
    Inventors: Hiroshi Yoshioka, Sunao Kubota, Yuichi Mori, Yasuharu Noishiki
  • Publication number: 20010053839
    Abstract: Disclosed is a chemically crosslinked material, comprising a natural material or a derivative thereof having crosslinks formed by the combination of a primary crosslinking agent and an enhancer compound, wherein the crosslinks formed comprise crosslinks which include at least one additional hydroxyl group and/or at least one additional linear ether linkage as compared to crosslinks formed by the primary crosslinking agent alone. The materials according to preferred embodiments of the invention provide a chemically crosslinked material that has favorable antigenicity/flexibility characteristics.
    Type: Application
    Filed: June 12, 2001
    Publication date: December 20, 2001
    Applicant: KOKEN CO. LTD.
    Inventors: Yasuharu Noishiki, Teruo Miyata, Hiroshi Ito
  • Patent number: 5986168
    Abstract: The present invention relates to a prosthesis comprising one or more bioabsorbable substances insolubilized and/or immobilized in place by a physical method which excludes chemical reagents. A growth factor can be bound to the bioabsorbable substance for simulating growth of, for example, fibroblast and endothelial cells, around and into the prosthesis. The invention can include a porous fabric substrate having the bioabsorbable substance(s) insolubilized and immobilized therewithin by one or more of the physical methods. The physical method can include entanglement, dry-up, thermal crosslinkng, gamma irradiation, ultraviolet irradiation, or swelling up by hyper hydration with electric charge. The invention excludes the use of conventional chemical reagents, such as glutaraldehyde or formaldehyde, which are toxic. Since the invention does not use the chemical reagents of the prior art, it can avoid the toxicity and foreign body reaction problems associated therewith.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: November 16, 1999
    Assignee: Nicem, Ltd.
    Inventor: Yasuharu Noishiki
  • Patent number: 5116824
    Abstract: A biomaterial excellent in biocompatibility comprising a composite material of an N-acylchitosan and collagen is described. This biomaterial is suitable for used as a wound dressing material, vascular prosthesis, artificial skin or hemostatic agent.
    Type: Grant
    Filed: October 29, 1990
    Date of Patent: May 26, 1992
    Assignees: Katakura Chikkarin Co., Ltd., Koken Co., Ltd.
    Inventors: Teruo Miyata, Kazuhiko Kodaira, Hitoshi Higashijima, Takashi Kimura, Yasuharu Noishiki
  • Patent number: 5080670
    Abstract: A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.
    Type: Grant
    Filed: August 30, 1988
    Date of Patent: January 14, 1992
    Assignee: Koken Co., Ltd.
    Inventors: Eisaburo Imamura, Yasuharu Noishiki, Hitoshi Koyanagi, Teruo Miyata, Masayasu Furuse
  • Patent number: 4833200
    Abstract: An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is provided, wherein a synthetic polymer material is subjected to a coating or impregnating treatment with a collagen-containing solution, followed by heparinization of the collagen, and the heparinized collagen is fixed to the synthetic polymer material. This method allows manufacturing of antithrombogenic medical material with ease.
    Type: Grant
    Filed: July 25, 1986
    Date of Patent: May 23, 1989
    Assignee: Koken Co., Ltd.
    Inventors: Yasuharu Noishiki, Teruo Miyata
  • Patent number: 4806595
    Abstract: In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.
    Type: Grant
    Filed: August 1, 1986
    Date of Patent: February 21, 1989
    Assignee: Koken Co., Ltd.
    Inventors: Yasuharu Noishiki, Kazuhiko Kodaira, Masayasu Furuse, Teruo Miyata
  • Patent number: 4749689
    Abstract: This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.
    Type: Grant
    Filed: August 17, 1987
    Date of Patent: June 7, 1988
    Assignee: Koken Co., Ltd.
    Inventors: Teruo Miyata, Kazuhiko Kodaira, Masayasu Furuse, Yasuharu Noishiki
  • Patent number: 4704131
    Abstract: The medical material contains heparinized collagen in which heparin has been bonded to protamine covalently fixed on collagen, and, owing to its excellent compatibility with living bodies, especially, its superb antithrombotic property, can be suitably used as a substituent material for tissues or organs which are brought into direct contact with blood, namely, as aritificial vessels, artificial valves and patching materials for cardiovascular organs, and the above medical material is also suitable as a membrane having anti-adhesion effects. The medical material is obtained by immersing and treating a natural or artificial material successively in an aqueous protamine solution, an aqueous glutaraldehyde solution and an aqueous heparin solution.
    Type: Grant
    Filed: October 15, 1984
    Date of Patent: November 3, 1987
    Assignee: Koken Co., Ltd.
    Inventors: Yasuharu Noishiki, Teruo Miyata
  • Patent number: 4695280
    Abstract: The present invention relates to an artificial vascular graft having ultra fine fibers smaller than 0.5 denier in fineness as part of the inner wall. The artificial vascular graft of this invention is very flexible and produces very low blood leakage. The ease of performing anastomoses is greatly improved. Because of the ultra fine fiber there are many sites to which live cells adhere, the adaptability of the live cells to the fibers of the vascular graft increases, an excellent antithrombotic effect is exerted by the vascular graft, and the formation of the endothelial cells is satisfactory and is observed at a very early stage.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: September 22, 1987
    Assignee: Toray Industries, Inc.
    Inventors: Koji Watanabe, Miyoshi Okamoto, Yuichi Mori, Yasuharu Noishiki
  • Patent number: 4695281
    Abstract: The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH.sub.2 groups of said chains attached to poly peptide chains of the collagen so that the --NH.sub.2 groups are converted into groups having --COOH groups. This succinylation can be carried out by reacting succinic anhydride with the --NH.sub.2 groups of the collagen. Since the above medical material has excellent compatibility with living bodies, especially, with blood, it is suitable to use it as a replacement material for tissues and/or organs which are kept in contact with blood at their surfaces, namely, is suitable for use in artificial blood vessels, artificial valves, some parts of artificial hearts which are kept in contact with blood at said parts, etc. and as a patching material for hearts.
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: September 22, 1987
    Assignee: Koken Co., Ltd.
    Inventors: Teruo Miyata, Yasuharu Noishiki
  • Patent number: 4690973
    Abstract: This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced.
    Type: Grant
    Filed: July 15, 1986
    Date of Patent: September 1, 1987
    Assignee: Koken Company Limited
    Inventors: Yasuharu Noishiki, Kazuhiko Kodaira, Masayasu Furuse, Teruo Miyata, Takeaki Miyamoto, Hiraku Ito