Patents by Inventor Yasuhiro Abiru

Yasuhiro Abiru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230321030
    Abstract: Provided is a means useful for enjoying the physiological action of kaempferol. A plant extract contains 1 mg/g or more of a kaempferol aglycone on a dry-weight basis.
    Type: Application
    Filed: August 24, 2021
    Publication date: October 12, 2023
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yasutaka IKEDA, Tsubasa MIZOKAMI, Ryo SERIZAWA, Yasuhiro ABIRU, Naoto NORO
  • Publication number: 20220151276
    Abstract: The present invention provides a composition for improvement in physical activity efficiency, a composition for reducing fatigue, and a composition for improving dynamic/kinetic visual acuity, comprising a plant-derived extract and/or a plant-derived processed product.
    Type: Application
    Filed: February 26, 2020
    Publication date: May 19, 2022
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yasutaka IKEDA, Tsubasa MIZOKAMI, Minoru AKIYAMA, Yasuhiro ABIRU, Ayuko OYAMA
  • Publication number: 20210228540
    Abstract: The present application provides a method for improvement in physical activity efficiency, a method for reducing fatigue, and a method for improving dynamic/kinetic visual acuity, comprising administering a composition comprising a kaempferol analog to a subject in need thereof.
    Type: Application
    Filed: April 12, 2021
    Publication date: July 29, 2021
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yasutaka IKEDA, Tsubasa MIZOKAMI, Yasuhiro ABIRU, Minoru AKIYAMA, Ayuko OYAMA
  • Publication number: 20200323816
    Abstract: The present application provides a composition for improvement in physical activity efficiency, a composition for reducing fatigue, and a composition for improving dynamic/kinetic visual acuity, comprising a kaempferol analog.
    Type: Application
    Filed: August 30, 2018
    Publication date: October 15, 2020
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yasutaka IKEDA, tsubasa MIZOKAMI, Yasuhiro ABIRU, Minoru AKIYAMA, Ayuko OYAMA
  • Patent number: 9951360
    Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: April 24, 2018
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
  • Patent number: 9176124
    Abstract: The determination method of the present invention includes steps of measuring equol in a biological sample derived from a subject who has ingested soybean isoflavone by an immunological method using S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen, and determining an equol-producing ability of the subject based on the measured value of equol obtained in the above step.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: November 3, 2015
    Assignees: OTSUKA PHARMACEUTICAL CO., LTD., EIKEN KAGAKU KABUSHIKI KAISHA
    Inventors: Takayuki Minekawa, Kumiko Shindome, Katsushi Abe, Hiroshi Okuma, Chieko Ando, Yasuhiro Abiru
  • Publication number: 20150299748
    Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu ISONO, Hisako MORI, Tomomi UENO, Rieko ENDO, Megumi KUMEMURA, Yasuhiro ABIRU, Shigeto UCHIYAMA
  • Publication number: 20150240275
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Application
    Filed: February 13, 2015
    Publication date: August 27, 2015
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu SHIMADA, Setsuko YASUDA, Masayuki TAKAHASHI, Takashi HAYASHI, Norihiro MIYAZAWA, Yasuhiro ABIRU, Tadaaki OHTANI, Ikutaro SATO
  • Patent number: 9101159
    Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: August 11, 2015
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
  • Patent number: 8993296
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: March 31, 2015
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato
  • Publication number: 20140315264
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Application
    Filed: January 15, 2014
    Publication date: October 23, 2014
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Yoshikazu SHIMADA, Setsuko YASUDA, Masayuki TAKAHASHI, Takashi HAYASHI, Norihiro MIYAZAWA, Yasuhiro ABIRU, Tadaaki OHTANI, Ikutaro SATO
  • Patent number: 8669088
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: March 11, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato
  • Patent number: 8399232
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: March 19, 2013
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato
  • Publication number: 20120064550
    Abstract: An object of the present invention is to provide a method for measuring equol in a biological sample by an immunological method, a kit for the measurement, and a method for determining equol-producing ability of a subject. The measurement method of the present invention is characterized in that S-equol is used as at least one antigen selected from the group consisting of a standard antigen used for the preparation of a standard curve and a labeled antigen that competes with equol in a biological sample. The kit of the present invention is characterized in including S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen.
    Type: Application
    Filed: May 11, 2010
    Publication date: March 15, 2012
    Applicants: OTSUKA PHARMACEUTICAL CO., LTD., EIKEN KAGAKU KABUSHIKI KAISHA
    Inventors: Takayuki Minekawa, Kumiko Shindome, Katsushi Abe, Hiroshi Okuma, Chieko Ando, Yasuhiro Abiru
  • Publication number: 20110189134
    Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.
    Type: Application
    Filed: September 18, 2009
    Publication date: August 4, 2011
    Applicants: OTSUKA PHARMACEUTICAL CO., LTD., OTSUKA FOODS CO., LTD.
    Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
  • Publication number: 20100330627
    Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.
    Type: Application
    Filed: December 25, 2008
    Publication date: December 30, 2010
    Applicant: OTSUKA PHARMACEUTICAL CO. LTD.
    Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato