Patents by Inventor Yasuhiro Abiru
Yasuhiro Abiru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230321030Abstract: Provided is a means useful for enjoying the physiological action of kaempferol. A plant extract contains 1 mg/g or more of a kaempferol aglycone on a dry-weight basis.Type: ApplicationFiled: August 24, 2021Publication date: October 12, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yasutaka IKEDA, Tsubasa MIZOKAMI, Ryo SERIZAWA, Yasuhiro ABIRU, Naoto NORO
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Publication number: 20220151276Abstract: The present invention provides a composition for improvement in physical activity efficiency, a composition for reducing fatigue, and a composition for improving dynamic/kinetic visual acuity, comprising a plant-derived extract and/or a plant-derived processed product.Type: ApplicationFiled: February 26, 2020Publication date: May 19, 2022Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yasutaka IKEDA, Tsubasa MIZOKAMI, Minoru AKIYAMA, Yasuhiro ABIRU, Ayuko OYAMA
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Publication number: 20210228540Abstract: The present application provides a method for improvement in physical activity efficiency, a method for reducing fatigue, and a method for improving dynamic/kinetic visual acuity, comprising administering a composition comprising a kaempferol analog to a subject in need thereof.Type: ApplicationFiled: April 12, 2021Publication date: July 29, 2021Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yasutaka IKEDA, Tsubasa MIZOKAMI, Yasuhiro ABIRU, Minoru AKIYAMA, Ayuko OYAMA
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Publication number: 20200323816Abstract: The present application provides a composition for improvement in physical activity efficiency, a composition for reducing fatigue, and a composition for improving dynamic/kinetic visual acuity, comprising a kaempferol analog.Type: ApplicationFiled: August 30, 2018Publication date: October 15, 2020Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yasutaka IKEDA, tsubasa MIZOKAMI, Yasuhiro ABIRU, Minoru AKIYAMA, Ayuko OYAMA
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Patent number: 9951360Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: GrantFiled: June 30, 2015Date of Patent: April 24, 2018Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Patent number: 9176124Abstract: The determination method of the present invention includes steps of measuring equol in a biological sample derived from a subject who has ingested soybean isoflavone by an immunological method using S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen, and determining an equol-producing ability of the subject based on the measured value of equol obtained in the above step.Type: GrantFiled: May 11, 2010Date of Patent: November 3, 2015Assignees: OTSUKA PHARMACEUTICAL CO., LTD., EIKEN KAGAKU KABUSHIKI KAISHAInventors: Takayuki Minekawa, Kumiko Shindome, Katsushi Abe, Hiroshi Okuma, Chieko Ando, Yasuhiro Abiru
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Publication number: 20150299748Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: ApplicationFiled: June 30, 2015Publication date: October 22, 2015Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu ISONO, Hisako MORI, Tomomi UENO, Rieko ENDO, Megumi KUMEMURA, Yasuhiro ABIRU, Shigeto UCHIYAMA
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Publication number: 20150240275Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.Type: ApplicationFiled: February 13, 2015Publication date: August 27, 2015Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu SHIMADA, Setsuko YASUDA, Masayuki TAKAHASHI, Takashi HAYASHI, Norihiro MIYAZAWA, Yasuhiro ABIRU, Tadaaki OHTANI, Ikutaro SATO
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Patent number: 9101159Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: GrantFiled: September 18, 2009Date of Patent: August 11, 2015Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Patent number: 8993296Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.Type: GrantFiled: January 15, 2014Date of Patent: March 31, 2015Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato
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Publication number: 20140315264Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.Type: ApplicationFiled: January 15, 2014Publication date: October 23, 2014Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu SHIMADA, Setsuko YASUDA, Masayuki TAKAHASHI, Takashi HAYASHI, Norihiro MIYAZAWA, Yasuhiro ABIRU, Tadaaki OHTANI, Ikutaro SATO
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Patent number: 8669088Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.Type: GrantFiled: November 5, 2012Date of Patent: March 11, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato
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Patent number: 8399232Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.Type: GrantFiled: December 25, 2008Date of Patent: March 19, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato
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Publication number: 20120064550Abstract: An object of the present invention is to provide a method for measuring equol in a biological sample by an immunological method, a kit for the measurement, and a method for determining equol-producing ability of a subject. The measurement method of the present invention is characterized in that S-equol is used as at least one antigen selected from the group consisting of a standard antigen used for the preparation of a standard curve and a labeled antigen that competes with equol in a biological sample. The kit of the present invention is characterized in including S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen.Type: ApplicationFiled: May 11, 2010Publication date: March 15, 2012Applicants: OTSUKA PHARMACEUTICAL CO., LTD., EIKEN KAGAKU KABUSHIKI KAISHAInventors: Takayuki Minekawa, Kumiko Shindome, Katsushi Abe, Hiroshi Okuma, Chieko Ando, Yasuhiro Abiru
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Publication number: 20110189134Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: ApplicationFiled: September 18, 2009Publication date: August 4, 2011Applicants: OTSUKA PHARMACEUTICAL CO., LTD., OTSUKA FOODS CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Publication number: 20100330627Abstract: An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.Type: ApplicationFiled: December 25, 2008Publication date: December 30, 2010Applicant: OTSUKA PHARMACEUTICAL CO. LTD.Inventors: Yoshikazu Shimada, Setsuko Yasuda, Masayuki Takahashi, Takashi Hayashi, Norihiro Miyazawa, Yasuhiro Abiru, Tadaaki Ohtani, Ikutaro Sato