Abstract: The object of the present invention is to provide a detecting agent for specifically detecting a tumor cell, a tumor antigen peptide-specifically presented on a tumor cell, a pharmaceutical composition useful for the prevention and/or treatment of cancer, the pharmaceutical composition containing the tumor antigen peptide as an active ingredient, etc. The above object has been achieved by a tumor antigen peptide or its motif-substituted product, the tumor antigen peptide comprising 8 to 14 consecutive amino acids in an amino acid sequence of a protein encoded by a gene selected from the group consisting of PVT1, SUV39H2, ZNF724P, SNRNP40, and DYRK4, the tumor antigen peptide having an HLA binding ability.

Abstract: Provided is a method for producing purified acetic acid with a good hue. A method for producing purified acetic acid, including treating acetic acid having a poor hue with a synthetic adsorbent to obtain acetic acid with an improved hue. The acetic acid to be treated is, for example, acetic acid having an absorbance of 0.01 or greater at a wavelength of 430 nm. The acetic acid to be treated may be acetic acid recovered from an acetic acid-containing solution that is discharged in a cellulose acetate production process. The synthetic adsorbent may have a cation exchange group on a resin surface. The synthetic adsorbent may have a pore structure.

Abstract: The object of the present invention is to provide a detecting agent for specifically detecting a tumor cell, a tumor antigen peptide-specifically presented on a tumor cell, a pharmaceutical composition useful for the prevention and/or treatment of cancer, the pharmaceutical composition containing the tumor antigen peptide as an active ingredient, etc. The above object has been achieved by a tumor antigen peptide or its motif-substituted product, the tumor antigen peptide comprising 8 to 14 consecutive amino acids in an amino acid sequence of a protein encoded by a gene selected from the group consisting of PVT1, SUV39H2, ZNF724P, SNRNP40, and DYRK4, the tumor antigen peptide having an HLA binding ability.

Abstract: A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas in the culture vessel; a humidifying pan disposed on the bottom of the culture vessel and positioned inside the duct; a heat pipe having a heat insulating section, a heat input section disposed at one end of the heat insulating section and a heat dissipation section disposed at the other end of the heat insulating section. The heat pipe is attached to the culture apparatus with the heat dissipation section being disposed outside the culture apparatus, the heat insulating section passing through the heat insulating box main body and the inner box, and the heat input section being disposed in a gas passage in the duct.

Abstract: A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas in the culture vessel; a humidifying pan disposed on the bottom of the culture vessel and positioned inside the duct; a heat pipe having a heat insulating section, a heat input section disposed at one end of the heat insulating section and a heat dissipation section disposed at the other end of the heat insulating section. The heat pipe is attached to the culture apparatus with the heat dissipation section being disposed outside the culture apparatus, the heat insulating section passing through the heat insulating box main body and the inner box, and the heat input section being disposed in a gas passage in the duct.

Abstract: A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas in the culture vessel; a humidifying pan disposed on the bottom of the culture vessel and positioned inside the duct; a heat pipe having a heat insulating section, a heat input section disposed at one end of the heat insulating section and a heat dissipation section disposed at the other end of the heat insulating section. The heat pipe is attached to the culture apparatus with the heat dissipation section being disposed outside the culture apparatus, the heat insulating section passing through the heat insulating box main body and the inner box, and the heat input section being disposed in a gas passage in the duct.

Abstract: A resist film is formed on a cold-rolled steel sheet so as to fabricate a groove by etching. At this point, a steel sheet exposed portion where a portion of the steel sheet is exposed is formed in the resist film, and the steel sheet exposed portion has a first region oriented in a sheet width direction, and a plurality of second regions starting from the first region, widths of the first region and the second regions being 20 ?m to 100 ?m, and a distance from an end portion of one of the second regions to an end portion of another of the second regions adjacent thereto being 60 ?m to 570 ?m.

Abstract: A culture apparatus comprising: an inner box configured to form a culture chamber; an outer box configured to cover the inner box; a fan configured to circulate gas inside the culture chamber through an air passage provided in the inner box within the culture chamber; a first through hole configured to penetrate a wall configuring a part of the air passage in the inner box; a second through hole configured to penetrate the wall and disposed at a position at which a flow velocity of the gas circulated through the air passage by the fan is lower than a flow velocity of the gas around the first through hole; a connecting pipe configured to connect the first through hole and the second through hole outside of the inner box; and a sensor configured to detect a concentration of the gas flowing in the culture chamber.

Abstract: A culture apparatus comprising: a fan configured to circulate air inside a culture chamber in a predetermined direction in the culture chamber; a duct configured to guide air circulating inside the culture chamber along a wall face inside the culture chamber from an upper part to a lower part of the culture chamber; and a gas generator detachable from a predetermined position at a lower part of the duct, the gas generator being configured to take in air discharged from a lower part of the duct and discharge together with the air taken in a hydrogen peroxide gas to sterilize the inside of the culture chamber generated from a hydrogen peroxide solution into the culture chamber.

Abstract: A resist film is formed on a cold-rolled steel sheet so as to fabricate a groove by etching. At this point, a steel sheet exposed portion where a portion of the steel sheet is exposed is formed in the resist film, and the steel sheet exposed portion has a first region oriented in a sheet width direction, and a plurality of second regions starting from the first region, widths of the first region and the second regions being 20 ?m to 100 ?m, and a distance from an end portion of one of the second regions to an end portion of another of the second regions adjacent thereto being 60 ?m to 570 ?m.

Abstract: A culture apparatus comprising: an inner box configured to form a culture chamber; an outer box configured to cover the inner box; a fan configured to circulate gas inside the culture chamber through an air passage provided in the inner box within the culture chamber; a first through hole configured to penetrate a wall configuring a part of the air passage in the inner box; a second through hole configured to penetrate the wall and disposed at a position at which a flow velocity of the gas circulated through the air passage by the fan is lower than a flow velocity of the gas around the first through hole; a connecting pipe configured to connect the first through hole and the second through hole outside of the inner box; and a sensor configured to detect a concentration of the gas flowing in the culture chamber.

Abstract: A culture apparatus comprising: a fan configured to circulate air inside a culture chamber in a predetermined direction in the culture chamber; a duct configured to guide air circulating inside the culture chamber along a wall face inside the culture chamber from an upper part to a lower part of the culture chamber; and a gas generator detachable from a predetermined position at a lower part of the duct, the gas generator being configured to take in air discharged from a lower part of the duct and discharge together with the air taken in a hydrogen peroxide gas to sterilize the inside of the culture chamber generated from a hydrogen peroxide solution into the culture chamber.

Abstract: A culture apparatus comprising: a housing including a culture chamber inside, culture being cultured in the culture chamber; a door configured to seal the culture chamber; an ultraviolet lamp configured to generate an ultraviolet ray for disinfecting air in the culture chamber; a lighting device configured to allow the ultraviolet lamp to be on for a predetermined time period, when the air in the culture chamber is disinfected; a detecting device configured to detect deterioration of disinfection capability of the ultraviolet lamp; and a controller configured to correct the predetermined time period, during which the ultraviolet lamp is on, so as to be longer according to the deterioration of the disinfection capability of the ultraviolet lamp detected by the detecting device.

Abstract: A culture apparatus includes a culture chamber in which culture is cultured, a shelf plate included in the culture chamber, on which the culture is placed, and shelf rests in a left-and-right pair configured to support the shelf plate and a plurality of shelf supports configured to support the shelf rests. The shelf rests each include one piece supporting the shelf plate and the other piece supported by the shelf supports. The shelf rests are in an L-shape in a cross-sectional manner whose angle between the one piece and the other piece is an acute angle. The one piece is in line contact with a lower face of the shelf plate at an end of the one piece extending obliquely upward from a side face of the culture chamber toward the inside of the culture chamber. The culture chamber is supplied with sterilizing gas to be sterilized.

Abstract: An object of the invention is to provide a multigas incubator capable of shortening humidity-returning time after closing its door. The incubator comprises an adiabatic box main body having an opening on a front face thereof, an adiabatic door mounted on the adiabatic box main body in an openable and closable manner, a transparent inner door for openably closing the opening, and an incubation room surrounded by the inner door and the adiabatic box main body for incubating samples such as cells, microbes and the like. The adiabatic box main body comprises an outer box made of a metal, an inner box made of a metal, a heat insulating material arranged inside the outer box between the outer and inner boxes, and an air layer arranged more inside than the heat insulating material. Gases supplied for controlling concentrations of gases in the incubation room are jetted into humidification water.

Abstract: A culture apparatus includes a culture chamber in which culture is cultured, a shelf plate included in the culture chamber, on which the culture is placed, and shelf rests in a left-and-right pair configured to support the shelf plate and a plurality of shelf supports configured to support the shelf rests. The shelf rests each include one piece supporting the shelf plate and the other piece supported by the shelf supports. The shelf rests are in an L-shape in a cross-sectional manner whose angle between the one piece and the other piece is an acute angle. The one piece is in line contact with a lower face of the shelf plate at an end of the one piece extending obliquely upward from a side face of the culture chamber toward the inside of the culture chamber. The culture chamber is supplied with sterilizing gas to be sterilized.

Abstract: A culture apparatus comprising: a housing including a culture chamber inside, culture being cultured in the culture chamber; a door configured to seal the culture chamber; an ultraviolet lamp configured to generate an ultraviolet ray for disinfecting air in the culture chamber; a lighting device configured to allow the ultraviolet lamp to be on for a predetermined time period, when the air in the culture chamber is disinfected; a detecting device configured to detect deterioration of disinfection capability of the ultraviolet lamp; and a controller configured to correct the predetermined time period, during which the ultraviolet lamp is on, so as to be longer according to the deterioration of the disinfection capability of the ultraviolet lamp detected by the detecting device.

Abstract: An object is to provide a reaction detecting device in which a height dimension of the device itself can be set to be small to realize space saving, unevenness of measurement sensitivity for each reaction container is minimized, and high-sensitivity and high-precision reaction detecting is possible, the device includes: a reflective plate disposed above a temperature controllable reaction block disposed in a reaction chamber constituted in a main body to reflect light; and a light source lamp and a camera arranged in the main body, the light from the light source lamp is reflected by the reflective plate to enter each reaction container from above, and light such as fluorescence directed upwards from a reaction specimen is reflected by the reflective plate to enter the camera.

Abstract: A gene which is useful in searching for a therapeutic agent which restores tissue that suffered damage in a renal disease, a polypeptide encoded by the gene and an antibody which recognizes the polypeptide, are provided. A gene whose expression level changes depending on progression and recovery of the pathology in a proliferative glomerulonephritis model animal is obtained, and a polypeptide encoded by the gene and an antibody which recognizes the polypeptide are produced. These gene, polypeptide and antibody can be used in the search for an agent for restoring kidney tissue that suffered damage and an agent for diagnosing kidney disorder.

Abstract: The present invention provides a method for inhibiting the activation of telomerase and an agent for inhibiting the activation of telomerase, a method for inhibiting telomerase activity and an agent for inhibiting telomerase activity, a method for preventing and/or a method for treating a cancer disease, an agent for preventing and/or an agent for treating a cancer disease, all of which comprises inhibiting the binding of MAPKAPK3 to TERT that is a catalytic subunit of telomerase or inhibiting the phosphorylation of TERT by active MAPKAPK3; a method of identifying a compound that inhibits the binding of MAPKAPK3 to TERT or a compound that inhibits the phosphorylation of TERT by active MAPKAPK3; and a reagent kit.