Patents by Inventor Yasuhiro Kohama

Yasuhiro Kohama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing angiotensin converting enzyme inhibitors
    Patent number: 5243027
    Abstract: A method of preparing an angiotensin converting enzyme inhibitor having the amino acid sequence selected from the group consisting of:Gly-Lys-Glu-Ile-Ile-Val-Lys-Ala-Glu-Arg (SEQ ID No: 1),Gly-Lys-Met-Val-Lys-Val-Val-Ser-Trp-Tyr (SEQ ID No: 2) andAla-Tyr-Ile-Ala-Ser-Lys-Gly-Leu (SEQ ID No: 3); which comprises the steps of:(a) disrupting bacteria to obtain a cell extract, wherein the disruption is at least one of mechanical and chemical disruption;(b) exposing said cell extract to an acid mixture comprising acetic acid and hydrochloric acid, wherein said acid mixture comprises acetic acid in a concentration of 0.01 to 10M and hydrochloric acid in a concentration of 1 to 100 mM, to produce an acid hydrolysate; and(c) purifying from said acid hydrolysate a peptide having the amino acid sequence selected from the group consisting of:Gly-Lys-Glu-Ile-Ile-Val-Lys-Ala-Glu-Arg (SEQ ID No: 1),Gly-Lys-Met-Val-Lys-Val-Val-Ser-Trp-Tyr (SEQ ID No: 2) andAla-Tyr-Ile-Ala-Ser-Lys-Gly-Leu (SEQ ID No: 3).
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: September 7, 1993
    Assignee: Unitika, Ltd.
    Inventors: Tsutomu Mimura, Yasuhiro Kohama, Kazuhiko Nagata, Ryoichi Tsurutani
  • Angiotensin converting enzyme inhibitor
    Patent number: 5098887
    Abstract: An angiotensin converting enzyme inhibitor containing Gly-Lys-Glu-Ile-Ile-Val-Lys-Ala-Glu-Arg (SEQ ID No: 1) Gly-Lys-Met-Val-Lys-Val-Val-Ser-Trp-Tyr (SEQ ID No: 2) or Ala-Tyr-Ile-Ala-Ser-Lys-Gly-Leu (SEQ ID No: 3) as an active component.
    Type: Grant
    Filed: February 26, 1991
    Date of Patent: March 24, 1992
    Assignee: Unitika Ltd.
    Inventors: Tsutomu Mimura, Yasuhiro Kohama, Kazuhiko Nagata, Ryoichi Tsurutani
  • Octopeptide exhibiting antimypertensive activity
    Patent number: 5071955
    Abstract: A novel peptide possessing excellent antihypertensive activity is disclosed. The peptide has the formula:Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (I)and can be prepared by purifying a fluid extracted from fish tissues or by combining constituting amino acids by a peptide synthesis method. It exhibits excellent ACE inhibitory activity, low toxicity, and good stability, and is thus an extremely useful and effective antihypertensive substance.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: December 10, 1991
    Assignees: Nippon Suisan Kaisha, Ltd., Mochida Pharmaceutical Co., Ltd.
    Inventors: Tsutomu Mimura, Yasuhiro Kohama, Mikio Satake, Yasukazu Nagase
  • Peptide derivatives
    Patent number: 4775743
    Abstract: New peptide derivatives represented by the following general formulaR.sub.1 -Pro-Hyp-R.sub.2wherein R.sub.1 is a hydrophobic radical, R.sub.2 is a hydrophilic radical, Pro is prolyl and Hyp is hydroxyprolyl show more powerful inhibitory action against platelet agglutination than conventional drugs and have potential use as anti-agglutination agent. The peptide derivative can be prepared by condensing a peptide containing a hydrophobic radical with a carboxylic acid containing a hydrophilic radical. The peptide derivative can be used in the form of parenteral injections, tablets, capsules or powder, the typical daily dose being in the range from 1 mg to 500 mg for adults.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: October 4, 1988
    Assignee: Green Cross Corporation
    Inventors: Tsutomu Mimura, Yasuhiro Kohama, Chikara Fukaya, Masahiro Watanabe, Kazumasa Yokoyama