Abstract: The present invention relates to an oral solid dosage form comprising N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof as an active ingredient, which has good dissolution and storage-stability. When the oral solid dosage form is a tablet, the tablet can be prepared while inhibiting tableting troubles from low content to high content of the active ingredient.

Abstract: A spot-size converter includes first and second waveguide structures. The first waveguide structure extends longitudinally along a waveguide axis from a first end to a second end and is configured to support a first optical mode at the first end. The second waveguide structure is formed within the first waveguide structure. The second waveguide structure extends longitudinally between the first end and the second end. The second waveguide structure is configured to support a second optical mode at the second end. The second optical mode has a different diameter than the first optical mode. The second waveguide structure includes a waveguide core that has a first cross-sectional area in a first plane normal to the waveguide axis at the first end and a second cross-sectional area in a second plane normal to the waveguide axis at the second end. The second cross-sectional area is larger than the first cross-sectional area.

Abstract: A distributed feedback plus reflection (DFB+R) laser includes an active section, a passive section, a low reflection (LR) mirror, and an etalon. The active section includes a distributed feedback (DFB) grating and is configured to operate in a lasing mode. The passive section is coupled end to end with the active section. The LR mirror is formed on or in the passive section. The etalon includes a portion of the DFB grating, the passive section, and the LR mirror. The lasing mode of the active section is aligned to a long-wavelength edge of a reflection peak of the etalon.

Abstract: A water treatment method includes a microbubble generating step (S101) of generating microbubbles in water to be treated containing at least calcium ions and producing water to be treated containing microbubbles, a water softening step (S102) of crystallizing calcium ions contained in the water to be treated containing the microbubbles as calcium carbonate and removing the calcium carbonate, and a reverse osmosis membrane treatment step (S103) of separating the water to be treated, from which the calcium carbonate has been removed, into reverse osmosis membrane treated water and reverse osmosis membrane concentrated water using a reverse osmosis membrane.

Abstract: A method of implementing membrane cleaning is provided. The method includes accessing a membrane resistance record, where the membrane resistance record includes a plurality of membrane resistance curves, each of the plurality of membrane resistance curves includes a curve profile after a cleaning. The method further includes performing a first cleaning, determining a first membrane resistance after the first cleaning, determining a current position on the curve profile based on the first membrane resistance and a time period from a previous cleaning, and performing a second cleaning. The second cleaning may include a recovery cleaning when the current position on the curve profile exceeds a predetermined range, and a maintenance cleaning when the current position on the curve profile is within the predetermined range.

Abstract: A water treatment method including: a concentration step of concentrating microorganisms in sample water to purify a concentrate; a detection step of detecting an inhibitor contained in the sample water or the concentrate; a determination step of determining whether to perform a removal step based on a result of the detection in the detection step; the removal step of removing the inhibitor from the concentrate in a case where the removal step is determined to be performed in the determination step; and a measurement step performed after the determination step or the removal step, of measuring the microorganisms contained in the concentrate.

Abstract: A support device includes an acquirer configured to acquire data indicating water quality information of water to be treated, a pressure to supply the water to be treated to a membrane filtration device, a transmembrane pressure at a filtration membrane, a permeation flux at the filtration membrane, a frequency and cleaning conditions for cleaning the filtration membrane with cleaning water, and an outputter configured to output an optimum value of a current permeation flux, and a frequency and cleaning conditions for cleaning the membrane filtration device with the cleaning water in the future based on the data indicating the water quality information of the water to be treated, the pressure to supply the water to be treated to the membrane filtration device, and the transmembrane pressure at the filtration membrane, that have been acquired by the acquirer, by using a learned determination model acquired by performing learning processing using the data acquired by the acquirer.

Abstract: A wastewater treatment method includes: a soft water treatment 1 of crystallizing calcium carbonate from wastewater to remove the calcium carbonate therefrom; and an electrolysis 2 of electrolyzing some of the wastewater from which the calcium carbonate has been removed to obtain an acidic aqueous solution and an alkaline aqueous solution, wherein at least some of the alkaline aqueous solution is circulated to be used in the soft water treatment 1.

Abstract: A laser includes a substrate, first and second claddings, a gain medium, and multiple supports. The first cladding is spaced apart from the substrate by an air gap. A thickness of the first cladding in a vertical direction is in a range from 0.05-0.15 micrometers. The gain medium is disposed on the first cladding opposite the air gap. The second cladding is disposed on the gain medium opposite the first cladding. A thickness of the second cladding in the vertical direction is in a range from 0.05-0.15 micrometers. The supports are coupled to each of the substrate, the first cladding, the gain medium, and the second cladding to retain the first cladding, the gain medium, and the second cladding spaced apart from the substrate.

Abstract: A water treatment system includes an equipment system including each water treatment device that executes a water treatment process and a control apparatus that controls each water treatment device, and a management system including a management apparatus that determines a control content of the water treatment process by using a virtual system obtained by virtualizing each water treatment device and controls the water treatment process of the equipment system based on the control content via the control apparatus of the equipment system.

Abstract: A wastewater treatment method includes: a soft water treatment 1 of crystallizing calcium carbonate from wastewater to remove the calcium carbonate therefrom; and an electrolysis 2 of electrolyzing some of the wastewater from which the calcium carbonate has been removed to obtain an acidic aqueous solution and an alkaline aqueous solution, wherein at least some of the alkaline aqueous solution is circulated to be used in the soft water treatment 1.

Abstract: A controller stabilizes a distributed feedback plus reflection (DFB+R) laser, which has a back facet, a DFB section, a passive section, and a front facet with a low reflective element. An etalon filter is formed by a portion of the DFB section, the passive section, and the low reflective element. Control circuitry directly modulates the DFB section with a modulation signal and biases the passive section with a bias signal. In operation, a lasing mode of the DFB section is aligned to a long wavelength edge of one of the periodic peaks of a reflection profile of the etalon filter. Meanwhile, photodiodes are arranged to monitor the output power emitted from the laser's front and back facets. The control circuitry monitors a ratio of the detected output power and adjusts the bias based on the monitored ratio.

Abstract: A grating coupled laser (GCL) includes an active section and a passive section. The passive section is butt coupled to the active section to form a butt joint with the active section. The active section includes an active waveguide. The passive section includes a passive waveguide, a transmit grating coupler, and a top cladding. The passive waveguide is optically coupled end to end with the active waveguide and includes a first portion and a second portion. The first portion of the passive waveguide is positioned between the second portion of the passive waveguide and the active waveguide. The transmit grating coupler is optically coupled to the passive waveguide and includes grating teeth that extend upward from the second portion of the passive waveguide. The top cladding is positioned directly above the first portion of the passive waveguide and is absent directly above at least some of the transmit grating coupler.

Abstract: A distributed feedback plus reflection (DFB+R) laser includes an active section, a passive section, a low reflection (LR) mirror, and an etalon. The active section includes a distributed feedback (DFB) grating and is configured to operate in a lasing mode. The passive section is coupled end to end with the active section. The LR mirror is formed on or in the passive section. The etalon includes a portion of the DFB grating, the passive section, and the LR mirror. The lasing mode of the active section is aligned to a long wavelength edge of a reflection peak of the etalon.

Abstract: A laser includes a substrate, first and second claddings, a gain medium, and multiple supports. The first cladding is spaced apart from the substrate by an air gap. A thickness of the first cladding in a vertical direction is in a range from 0.05-0.15 micrometers. The gain medium is disposed on the first cladding opposite the air gap. The second cladding is disposed on the gain medium opposite the first cladding. A thickness of the second cladding in the vertical direction is in a range from 0.05-0.15 micrometers. The supports are coupled to each of the substrate, the first cladding, the gain medium, and the second cladding to retain the first cladding, the gain medium, and the second cladding spaced apart from the substrate.

Abstract: A spot-size converter includes first and second waveguide structures. The first waveguide structure extends longitudinally along a waveguide axis from a first end to a second end and is configured to support a first optical mode at the first end. The second waveguide structure is formed within the first waveguide structure. The second waveguide structure extends longitudinally between the first end and the second end. The second waveguide structure is configured to support a second optical mode at the second end. The second optical mode has a different diameter than the first optical mode. The second waveguide structure includes a waveguide core that has a first cross-sectional area in a first plane normal to the waveguide axis at the first end and a second cross-sectional area in a second plane normal to the waveguide axis at the second end. The second cross-sectional area is larger than the first cross-sectional area.

Abstract: A distributed feedback plus reflection (DFB+R) laser includes an active section, a passive section, a low reflection (LR) mirror, and an etalon. The active section includes a distributed feedback (DFB) grating and is configured to operate in a lasing mode. The passive section is coupled end to end with the active section. The LR mirror is formed on or in the passive section. The etalon includes a portion of the DFB grating, the passive section, and the LR mirror. The lasing mode of the active section is aligned to a long wavelength edge of a reflection peak of the etalon.

Abstract: A two-kappa DBR laser includes an active section, a HR mirror, a first DBR section, and a second DBR section. The HR mirror is coupled to a rear of the active section. The first DBR section is coupled to a front of the active section, the first DBR section having a first DBR grating with a first kappa ?1. The second DBR section is coupled to a front of the first DBR section such that the first DBR section is positioned between the active section and the second DBR section. The second DBR section has a second DBR grating with a second kappa ?2 less than the first kappa ?1. The two-kappa DBR laser is configured to operate in a lasing mode and has a DBR reflection profile that includes a DBR reflection peak. The lasing mode is aligned to a long wavelength edge of the DBR reflection peak.

Abstract: The present disclosure relates to a solid oral dosage form comprising: (i) (S)-4-amino-5-chloro-N-[{4-[(1-hydroxyacetyl-4-piperidinyl)methyl]-2-morpholinyl}methyl]-2-methoxybenzamide, a pharmaceutically acceptable salt thereof, or a hydrate or solvate of the same; (ii) a disintegrating agent; and (iii) a water-soluble polymer binder. The present disclosure also relates to a medicinal composition, a therapeutic agent and/or a preventive agent, which comprise the medicine according to the present disclosure, for treating and/or preventing digestive diseases, digestive symptoms, psychoneurological diseases or urinary diseases, a preferable example thereof being a solid oral dosage form.

Abstract: A system includes a grating coupled laser and a photonic integrated circuit (PIC). The grating coupled laser includes a first waveguide and a transmit grating coupler optically coupled to the first waveguide. The PIC includes a second waveguide and a receive grating coupler optically coupled to the second waveguide. The receive grating coupler is in optical alignment with the transmit grating coupler. The receive grating coupler includes a first grating and a second grating spaced apart from and above the first grating within the PIC.