Patents by Inventor Yasuhiro Mito

Yasuhiro Mito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10802005
    Abstract: A chromatogram data processing system having an impurity detector including a differential chromatogram creator, a purity curve creator and a determiner. The differential chromatogram creator calculates a differential coefficient of an absorbance spectrum with respect to wavelength at a local maximum or local minimum absorption wavelength of the target component, and creates a differential chromatogram which shows a temporal change of the differential coefficient. The purity curve creator creates a purity curve which shows a temporal change of the difference between the degree of similarity of a spectrum on the target peak to a reference spectrum and a threshold of the degree of similarity which is determined taking into account the influence of noise components. The differential chromatogram and the purity curve are displayed on a display unit in a superposed form on a wavelength chromatogram created by a wavelength chromatogram creator.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: October 13, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Kenichi Mishima, Etsuho Kamata, Hiroshi Miura, Yasuhiro Mito, Toshinobu Yanagisawa
  • Patent number: 10697946
    Abstract: A system for creating a chromatogram based on a temporal change of a spectrum obtained within a predetermined wavelength range including a target wavelength, the system including a post-correction chromatogram display section for displaying a post-correction chromatogram obtained by multiplying a chromatogram at the designated wavelength by a sensitivity factor obtained by dividing the intensity of the designated-time spectrum at the target wavelength by the intensity of the designated-time spectrum at the designated wavelength, and for changing the display to a post-correction chromatogram corresponding to the latest values of the designated time point and the designated wavelength when one or both of the designated time point and the designated wavelength are changed.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: June 30, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Etsuho Kamata, Toshinobu Yanagisawa, Yasuhiro Mito, Kenichi Mishima
  • Patent number: 10481138
    Abstract: Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impur
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: November 19, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Kenichi Mishima, Etsuho Kamata, Hiroshi Miura, Yasuhiro Mito, Toshinobu Yanagisawa
  • Patent number: 10429365
    Abstract: For vector A which expresses an absorption spectrum of a target component, vector F orthogonal to vector A is designated as a filter for extracting an impurity superposed on the target component on a chromatogram. For vector I which expresses a measured spectrum obtained by a chromatographic analysis performed on a sample, the inner product of vectors I and F is defined as an index value u of the amount of impurity. If an impurity is present, a peak-like waveform appears on a graph which shows a temporal change in the index value u for the measured spectrum obtained at each point in time of the measurement. By detecting this waveform, the presence or absence of the impurity can be correctly determined. The direction of vector F may be determined so that, when vector B which expresses a spectrum of the impurity is decomposed into vector Ba parallel to vector A and vector Bo orthogonal to vector A, vector F becomes nearly parallel to vector Bo (i.e. the cosine similarity index is maximized).
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: October 1, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Akira Noda, Yasuhiro Mito
  • Patent number: 10386346
    Abstract: A data processing system for a chromatograph has an impurity detector including a differential chromatogram creator and a determining section. The differential chromatogram creator calculates a wavelength differential coefficient by differentiating an absorbance spectrum with respect to the wavelength at each point in time of the measurement and creates a differential chromatogram which shows a temporal change in the wavelength differential coefficient. Based on a shape of the thus created differential chromatogram, the determining section determines whether or not a peak of a target component contains an impurity. By this method, whether or not the peak of the target component contains an impurity can be determined with high accuracy, without requiring complex calculations.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: August 20, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Yasuhiro Mito, Etsuho Kamata, Hiroshi Miura, Kenichi Mishima, Toshinobu Yanagisawa
  • Patent number: 10309940
    Abstract: There are provided a data processing device for chromatograph and a data processing method for chromatograph which allow a peak to be desirably checked. A peak (correction target peak (P1)) whose intensity exceeds a predetermined threshold in a chromatogram at a target wavelength (?1) is corrected based on correction reference values (height (H1) and area (A1) of a peak (P11)) and a sensitivity coefficient (R=I1/I2), and the chromatogram after correction is displayed or printed. Therefore, even if the correction target peak (P1) is saturated, display or printing may be performed in a state where correction has been performed so that the chromatogram at the peak (P1) is not cut off in the middle. Accordingly, at the time of display or printing of the chromatogram, a fine peak may be prevented from becoming too small, and also the correction target peak (P1) may be prevented from being cut off in the middle, and thus the peaks may be desirably checked.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: June 4, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Etsuho Kamata, Toshinobu Yanagisawa, Yasuhiro Mito, Kenichi Mishima
  • Patent number: 10184925
    Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: January 22, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Yasuhiro Mito, Etsuho Kamata, Hiroshi Miura, Kenichi Mishima, Toshinobu Yanagisawa
  • Patent number: 10151734
    Abstract: A data processing system for a chromatograph including a standard sample data storage section; a standard sample sensitivity factor calculator; a post-correction standard sample chromatogram strength calculator; a specific designated retention time and specific designated wavelength setter; a measurement sample data storage section; a measurement sample sensitivity factor calculator; and a post-correction measurement sample chromatogram creator.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: December 11, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Etsuho Kamata, Toshinobu Yanagisawa, Yasuhiro Mito, Kenichi Mishima
  • Publication number: 20180321200
    Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 8, 2018
    Applicant: SHIMADZU CORPORATION
    Inventors: Yasuhiro MITO, Etsuho KAMATA, Hiroshi MIURA, Kenichi MISHIMA, Toshinobu YANAGISAWA
  • Patent number: 10048237
    Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: August 14, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Yasuhiro Mito, Etsuho Kamata, Hiroshi Miura, Kenichi Mishima, Toshinobu Yanagisawa
  • Patent number: 9453825
    Abstract: An apparatus and a method for chromatogram peak purity determination are provided, where the chromatogram's dimensions consist of retention time, wavelength and absorbance. The apparatus or method accumulates, at each retention time, absorbance in the wavelength direction for all or a part of a wavelength range in a predetermined retention time range; extracts a plurality of groups where, for each group, the absorbance accumulation value is the same for one point on a rising slope and one point on a falling slope regarding a peak that exists on a chromatogram that is prepared based on a 2-dimensional data whose dimensions are absorbance accumulation value and retention time; calculates similarities between absorption spectrum pattern at one point on the rising slope and at one point on the falling slope for each group; and determines from the plurality of groups, whether the peak consists of a single component based on similarity.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: September 27, 2016
    Assignee: SHIMADZU CORPORATION
    Inventor: Yasuhiro Mito
  • Publication number: 20160231297
    Abstract: For vector A which expresses an absorption spectrum of a target component, vector F orthogonal to vector A is designated as a filter for extracting an impurity superposed on the target component on a chromatogram. For vector I which expresses a measured spectrum obtained by a chromatographic analysis performed on a sample, the inner product of vectors I and F is defined as an index value u of the amount of impurity. If an impurity is present, a peak-like waveform appears on a graph which shows a temporal change in the index value u for the measured spectrum obtained at each point in time of the measurement. By detecting this waveform, the presence or absence of the impurity can be correctly determined. The direction of vector F may be determined so that, when vector B which expresses a spectrum of the impurity is decomposed into vector Ba parallel to vector A and vector Bo orthogonal to vector A, vector F becomes nearly parallel to vector Bo (i.e. the cosine similarity index is maximized).
    Type: Application
    Filed: October 16, 2013
    Publication date: August 11, 2016
    Applicant: SHIMADZU CORPORATION
    Inventors: Akira NODA, Yasuhiro MITO
  • Publication number: 20160216240
    Abstract: A data processing system for a chromatograph including a standard sample data storage section; a standard sample sensitivity factor calculator; a post-correction standard sample chromatogram strength calculator; a specific designated retention time and specific designated wavelength setter; a measurement sample data storage section; a measurement sample sensitivity factor calculator; and a post-correction measurement sample chromatogram creator.
    Type: Application
    Filed: September 2, 2013
    Publication date: July 28, 2016
    Applicant: SHIMADZU CORPORATION
    Inventors: Etsuho KAMATA, Toshinobu YANAGISAWA, Yasuhiro MITO, Kenichi MISHIMA
  • Publication number: 20160209380
    Abstract: A chromatogram data processing system having an impurity detector including a differential chromatogram creator, a purity curve creator and a determiner. The differential chromatogram creator calculates a differential coefficient of an absorbance spectrum with respect to wavelength at a local maximum or local minimum absorption wavelength of the target component, and creates a differential chromatogram which shows a temporal change of the differential coefficient. The purity curve creator creates a purity curve which shows a temporal change of the difference between the degree of similarity of a spectrum on the target peak to a reference spectrum and a threshold of the degree of similarity which is determined taking into account the influence of noise components. The differential chromatogram and the purity curve are displayed on a display unit in a superposed form on a wavelength chromatogram created by a wavelength chromatogram creator.
    Type: Application
    Filed: May 20, 2014
    Publication date: July 21, 2016
    Applicant: SHIMADZU CORPORATION
    Inventors: Kenichi MISHIMA, Etsuho KAMATA, Hiroshi MIURA, Yasuhiro MITO, Toshinobu YANAGISAWA
  • Publication number: 20160169849
    Abstract: A system for creating a chromatogram based on a temporal change of a spectrum obtained within a predetermined wavelength range including a target wavelength, the system including a post-correction chromatogram display section for displaying a post-correction chromatogram obtained by multiplying a chromatogram at the designated wavelength by a sensitivity factor obtained by dividing the intensity of the designated-time spectrum at the target wavelength by the intensity of the designated-time spectrum at the designated wavelength, and for changing the display to a post-correction chromatogram corresponding to the latest values of the designated time point and the designated wavelength when one or both of the designated time point and the designated wavelength are changed.
    Type: Application
    Filed: July 29, 2013
    Publication date: June 16, 2016
    Applicant: SHIMADZU CORPORATION
    Inventors: Etsuho KAMATA, Toshinobu YANAGISAWA, Yasuhiro MITO, Kenichi MISHIMA
  • Publication number: 20160169848
    Abstract: There are provided a data processing device for chromatograph and a data processing method for chromatograph which allow a peak to be desirably checked. A peak (correction target peak (P1)) whose intensity exceeds a predetermined threshold in a chromatogram at a target wavelength (X1) is corrected based on correction reference values (height (H1) and area (A1) of a peak (P11)) and a sensitivity coefficient (R=I1/I2), and the chromatogram after correction is displayed or printed. Therefore, even if the correction target peak (P1) is saturated, display or printing may be performed in a state where correction has been performed so that the chromatogram at the peak (P1) is not cut off in the middle. Accordingly, at the time of display or printing of the chromatogram, a fine peak may be prevented from becoming too small, and also the correction target peak (P1) may be prevented from being cut off in the middle, and thus the peaks may be desirably checked.
    Type: Application
    Filed: August 5, 2013
    Publication date: June 16, 2016
    Applicant: SHIMADZU CORPORATION
    Inventors: Etsuho KAMATA, Toshinobu YANAGISAWA, Yasuhiro MITO, Kenichi MISHIMA
  • Publication number: 20160033457
    Abstract: Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impur
    Type: Application
    Filed: February 12, 2014
    Publication date: February 4, 2016
    Applicant: Shimadzu Corporation
    Inventors: Kenichi MISHIMA, Etsuho KAMATA, Hiroshi MIURA, Yasuhiro MITO, Toshinobu YANAGISAWA
  • Publication number: 20160018370
    Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.
    Type: Application
    Filed: March 4, 2013
    Publication date: January 21, 2016
    Applicant: SHIMADZU CORPORATION
    Inventors: Yasuhiro MITO, Etsuho KAMATA, Hiroshi MIURA, Kenichi MISHIMA, Toshinobu YANAGISAWA
  • Publication number: 20140257712
    Abstract: A data processing system for a chromatograph has an impurity detector including a differential chromatogram creator and a determining section. The differential chromatogram creator calculates a wavelength differential coefficient by differentiating an absorbance spectrum with respect to the wavelength at each point in time of the measurement and creates a differential chromatogram which shows a temporal change in the wavelength differential coefficient. Based on a shape of the thus created differential chromatogram, the determining section determines whether or not a peak of a target component contains an impurity. By this method, whether or not the peak of the target component contains an impurity can be determined with high accuracy, without requiring complex calculations.
    Type: Application
    Filed: August 31, 2012
    Publication date: September 11, 2014
    Applicant: SHIMADZU CORPORATION
    Inventors: Yasuhiro Mito, Etsuho Kamata, Hiroshi Miura, Kenichi Mishima, Toshinobu Yanagisawa
  • Publication number: 20140067283
    Abstract: An apparatus and a method for chromatogram peak purity determination are provided, where the chromatogram's dimensions consist of retention time, wavelength and absorbance. The apparatus or method accumulates, at each retention time, absorbance in the wavelength direction for all or a part of a wavelength range in a predetermined retention time range; extracts a plurality of groups where, for each group, the absorbance accumulation value is the same for one point on a rising slope and one point on a falling slope regarding a peak that exists on a chromatogram that is prepared based on a 2-dimensional data whose dimensions are absorbance accumulation value and retention time; calculates similarities between absorption spectrum pattern at one point on the rising slope and at one point on the falling slope for each group; and determines from the plurality of groups, whether the peak consists of a single component based on similarity.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 6, 2014
    Applicant: SHIMADZU CORPORATION
    Inventor: Yasuhiro MITO