Abstract: The system includes a sensor for detecting a state of a space; a robot for executing a handling job for an article; an article identifying part for identifying, when an article is handled by a movable body, the article in response to a detection result obtained by the sensor; and an article handling subject identifying part for identifying an article handling subject that handles the article. When the movable body that handles the article is the robot, the article handling subject identifying part identifies a subject having issued a job instruction to the robot as the article handling subject.

Abstract: A color filter arrangement (11) is used, in which a plurality of filter units are each made of 2×2 arrangements of red (R), green (G), green (G) and blue (B) color elements. First, signal charges are added up for all pixels belonging to each of a plurality of pixel blocks made of quadratic arrangements of 3×3 of pixels, which are larger than the filter units (2×2 arrangement). Then, compressed color information for each of the pixel blocks is obtained from a result of the addition for each pixel block, taking the 2×2 arrangements of pixel blocks as large filter units.

Abstract: Gray level data of boundary pixels that are adjacent to a block boundary in a photoelectric conversion section is stored. Then, a cumulative histogram regarding the number of pixels for different gray levels is produced based on the stored gray level data separately for each block, and a data table representing the correspondence between each gray level before correction and that after correction for the block to be corrected is produced so as to reduce the difference between the cumulative histograms. The data table is stored in a correction data RAM. By using the data table, the outputs of the block to be corrected are non-linearly corrected for different gray levels.

Abstract: The system includes sensing means 120 for detecting a state of a space; a robot 102 for executing a handling job for an article; an article identifying part 32 for identifying, when an article is handled by a movable body, the article in response to a detection result obtained by the sensing means 120; and an article handling subject identifying part 33 for identifying an article handling subject that handles the article. When the movable body that handles the article is the robot 102, the article handling subject identifying part 33 identifies a subject having issued a job instruction to the robot 102 as the article handling subject.

Abstract: In a solid-state imaging device, a plurality of vertical charge transfer paths is arranged at a horizontal pitch A within a photoelectric conversion region, and at a pitch B that is smaller than the pitch A in a portion where the signals are input into the horizontal charger transfer path. A read-out amplifier and a horizontal charge transfer path for receiving signals from vertical charge transfer paths are provided for each photoelectric conversion block into which the photoelectric conversion region has been partitioned. The read-out amplifiers have the same shape and their positional relation is one of parallel displacement in regions that are obtained by changing the pitch of the vertical charge transfer portions. Thus, a solid-state imaging device is achieved that is not so easily influenced by mask misalignments or skewed ion implantation angles, and in which signal read-out at high speeds is possible.

Abstract: A color filter arrangement (11) is used, in which a plurality of filter units are each made of 2×2 arrangements of red (R), green (G), green (G) and blue (B) color elements. First, signal charges are added up for all pixels belonging to each of a plurality of pixel blocks made of quadratic arrangements of 3×3 of pixels, which are larger than the filter units (2×2 arrangement). Then, compressed color information for each of the pixel blocks is obtained from a result of the addition for each pixel block, taking the 2×2 arrangements of pixel blocks as large filter units.

Abstract: Gray level data of boundary pixels that are adjacent to a block boundary in a photoelectric conversion section is stored. Then, a cumulative histogram regarding the number of pixels for different gray levels is produced based on the stored gray level data separately for each block, and a data table representing the correspondence between each gray level before correction and that after correction for the block to be corrected is produced so as to reduce the difference between the cumulative histograms. The data table is stored in a correction data RAM. By using the data table, the outputs of the block to be corrected are non-linearly corrected for different gray levels.

Abstract: The solid-state image pickup device permitting parallel readout having an image pickup section partitioned into strip blocks and a readout amplifier for each block further has: an input source; and a marker signal generation section for generating marker signals for correction of outputs of the readout amplifiers. The marker signal generation section has a marker charge storage portion made of capacitors for respectively storing an amount of charge corresponding to the potential at the input source. The marker signals having a same charge amount generated in the marker signal generation section are read through vertical CCDs of two adjacent blocks and corresponding horizontal CCDs and readout amplifiers sequentially.

Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.

Abstract: A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.

Abstract: Sialic acid derivatives represented by the general formula (I): whereinR.sup.1 is a steroidal compound residue;R.sup.2 is H or alkyl;R.sup.3 is alkyl; ##STR1## wherein each of R.sup.6 and R.sup.7 is H, alkyl or the like and I is an integer of 0 to 6; or the like;X is O or S;R.sup.4 is H or acyl; and R.sup.5 is R.sup.14 O--(R.sup.14 is H or acyl) or R.sup.15 NH--(R.sup.15 is acyl or the like);their salts, hydrates or solvates are provided.Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.

Abstract: A prolineamide derivative represented by the formula (I): ##STR1## or a salt or hydrate thereof or a pharmaceutically acceptable salt thereof, which has a protease inhibition activity and is useful as an active ingredient of pharmaceutical compositions is provided.

Abstract: Sialic acid derivatives represented by the general formula (I): ##STR1## wherein R.sup.1 is a steroidal compound residue; R.sup.2 is H or alkyl;R.sup.3 is alkyl; ##STR2## wherein each of R.sup.6 and R.sup.7 is H, alkyl or the like and I is an integer of 0 to 6; or the like;X is O or S;R.sup.4 is H or acyl; and R.sup.5 is R.sup.14 O-- (R.sup.14 is H or acyl) or R.sup.15 NH--(R.sup.15 is acyl or the like);their salts, hydrates or solvates are provided.Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.

Abstract: A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.

Abstract: A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.

Abstract: A 3,6-disubstituted pyridazine derivative having excellent platelet agglutination inhibitory effects. It is useful for a preventive medicine or a therapeutic medicine for a cerebrovascular disorder such as cerebral thrombosis and cerebral embolism, an ischemic heart disease such as myocardial infarction, and a circulation disorder such as peripheral circulation disorder. A pharmaceutical composition containing a compound of the present invention as an effective ingredient and a process for preparing the same are also disclosed.

Abstract: Aminoketone derivatives according to the present invention strongly inhibit thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L or the like and have excellent properties concerning absorbance on oral administration, tissue distribution and cell membrane permeability. The aminoketone derivatives cart thus be used as therapeutic agents for treating muscular dystrophy, cataract, cardiac infarction, stroke, Alzheimer's disease, amyotrophy, osteoporosis and hypercalcemia and so on. It may also be used as therapeutic agents for preventing metastasis of cancer. In addition, the present derivatives are also applicable as intermediates for the preparation of ketone derivatives, which have inhibitory activity against thiol protease.

Abstract: Alpha-aminoketone derivatives of the present invention strongly inhibit thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L and calpain or the like and have excellent properties in absorbance on oral administration, tissue distribution and cell membrane permeability. The alpha-aminoketone derivatives can thus be used as therapeutic agents for treating muscular dystrophy, amyotrophy, cardiac infarction, stroke, Alzheimer's disease, disturbance of consciousness or dyskinesia caused upon brain trauma, multiple sclerosis, peripheral nervous neuropathy, cataract, inflammation, allergosis, fulminant hepatitis, osteoporosis, hypercalcemia, breast carcinoma, prostatic carcinoma or prostatomegaly. They may also be used as therapeutic agents for suppressing growth of cancer cells, preventing metastasis of cancer or suppressing aggregation of plaques.

Abstract: A novel cyclopropenone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.

Abstract: A prophylactic and therapeutic agent for circulatory disorders, comprising a pyrazolone derivative of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom, an aryl group, an alkyl group having 1 to 5 carbon atoms or an alkoxycarbonylalkyl group having a total carbon number of 3 to 6; R.sub.2 represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group having 1 to 5 carbon atoms or hydroxyalkyl group having 1 to 3 carbon atoms or R.sub.1 and R.sub.2 taken together represent an alkylene group having 3 to 5 carbon atoms; R.sub.