Abstract: An optical unit includes an optical sensor, a protective cover disposed in a direction of view from the optical sensor, an actuator to drive the protective cover, and a casing including a space between the casing and the protective cover and to which the optical sensor and the protective cover are attached. A first region on the casing adjacent to an outer edge of the protective cover with the space interposed between the casing and the outer edge of the protective cover is a hydrophobic region where a contact angle of a droplet is equal to or larger than a predetermined angle.

Abstract: A control device and method controls a vehicle having an internal combustion engine connected to an automatic transmission via a torque converter with a lockup device. The torque of the internal combustion engine is limited the by a torque limit value based on a speed difference between an input rotational speed and an output rotational speed of the torque converter during acceleration in a non-lockup state. The torque-limiting of the internal combustion engine is prohibited torque-limiting upon a prescribed condition being met. The prescribed condition is met by a heating request, during hill climbing/towing, during travel at high vehicle speeds, when the accelerator pedal opening angle exceeds or is equal to a prescribed opening angle, when the torque limit value is greater than a target torque, in a range other than a D range, or in a mode other than normal mode.

Abstract: A non-transitory computer readable recording medium stores instructions for an information processing device that comprises a processor, a display device, and an audio output device. The instructions cause the processor to execute: acquiring, from a distribution server, a game video; acquiring, from a management system, operation information regarding a player playing a game in the game video, and event information on an event having occurred in the game based on the operation information; combining the game video, the operation information, and the event information to generate a final video; and presenting the final video via the display device and the audio output device.

Abstract: A non-transitory computer readable recording medium stores instructions for an information processing device that includes a processor, a display device, and an audio output device. The instructions cause the processor to execute: acquiring a game video from a distribution server; identifying a game based on the game video; acquiring reference information for a viewer of the game video from a management system that stores various types of reference information such that a different type of the reference information is acquired depending on the game identified based on the game video; combining the game video and the reference information to generate a final video; and presenting the final video via the display device and the audio output device.

Abstract: Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphylococcus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.

Abstract: Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.

Abstract: The present invention provides transthyretin amyloid-selective and polyreactive catabodies and method of use thereof.

Abstract: A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 . . . Lx . . . Lm are components defining a ligand determinant, Lx is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L? is a functional group of Lx, Y? is atom, covalent bond or linker, Y? is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.

Abstract: Improved methods for the production, selection and inhibition of catalytic and covalent antibodies are disclosed.

Abstract: The present invention provides a method of cooling a hot-rolled steel strip which has passed through a finishing rolling, including: cooling the hot-rolled steel strip from a first temperature of not lower than 600° C. and not higher than 650° C. to a second temperature of not higher than 450° C. with cooling water having the water amount density of not lower than 4 m3/m2/min and not higher than 10 m3/m2/min, wherein with respect to the area of the target surface, the area of a portion where a plurality of spray jets of the cooling water directly strikes on the target surface is at least 80%.

Abstract: The present invention provides a method of cooling a hot-rolled steel strip which has passed through a finishing rolling, including: cooling the hot-rolled steel strip from a first temperature of not lower than 600° C. and not higher than 650° C. to a second temperature of not higher than 450° C. with cooling water having the water amount density of not lower than 4 m3/m2/min and not higher than 10 m3/m2/min, wherein with respect to the area of the target surface, the area of a portion where a plurality of spray jets of the cooling water directly strikes on the target surface is at least 80%.

Abstract: The present invention provides a method of cooling a hot-rolled steel strip which has passed through a finishing rolling, including: cooling the hot-rolled steel strip from a first temperature of not lower than 600° C. and not higher than 650° C. to a second temperature of not higher than 450° C. with cooling water having the water amount density of not lower than 4 m3/m2/min and not higher than 10 m3/m2/min, wherein with respect to the area of the target surface, the area of a portion where a plurality of spray jets of the cooling water directly strikes on the target surface is at least 80%.

Abstract: The present invention relates to a method of arranging and setting spray nozzles in a cooling apparatus comprising a plurality of pairs of constraining rolls for constraining and conveying a hot steel plate and one or more lines of spray nozzles between the pair of constraining rolls, each line having a plurality of spray nozzles and is disposed in a direction perpendicular to processing, and to the cooling apparatus and the method of cooling. The invention is characterized in that the spray nozzles are arranged such that a distribution of values ?Pn between two edges of the steel plate in the direction perpendicular to processing is not less than 80% of its highest value, with P being cooling water impact pressure on the cooling surface, ?Pn being the value of n power of P integrated in the processing direction between the pairs of constraining rolls, and 0.05?n?0.2.

Abstract: Provided are immunogenic compositions based on the highly conserved, core CD4 binding site of the gp120 protein of the human immunodeficiency virus. One embodiment includes an antigenic conjugate of an electophilic derivative of HIV gp120 peptide 416-433, designated E-416-433, covalently linked to an immunogenic carrier protein. The compositions are effective in stimulating the production of HIV neutralizing antibodies in mammals. Provided also are related methods of immunization, methods of antibody production and antibodies obtained using the methods of the invention.

Abstract: The present invention provides a method of cooling a hot-rolled steel strip which has passed through a finishing rolling, including: cooling the hot-rolled steel strip from a first temperature of not lower than 600° C. and not higher than 650° C. to a second temperature of not higher than 450° C. with cooling water having the water amount density of not lower than 4 m3/m2/min and not higher than 10 m3/m2/min, wherein with respect to the area of the target surface, the area of a portion where a plurality of spray jets of the cooling water directly strikes on the target surface is at least 80%.

Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.

Abstract: The present invention relates to an apparatus for cooling hot steel plate applied for controlled cooling of hot steel plate, obtained by hot rolling, while processing it constrained by constraining rolls and obtaining a steel material excellent and uniform in shape characteristics and provides a method of arranging and setting spray nozzles enabling uniform cooling in a direction perpendicular to processing and provides a method of arranging and setting spray nozzles of a spray cooling apparatus using two or more types of nozzles differing in amounts of water and spray regions to obtain a broad range of adjustment of amounts of water, wherein the spray nozzles are arranged so that a value of an n power of the impact pressures of the cooling water sprayed from the spray on the cooling surface integrated in the processing direction between pairs of constraining rolls becomes within ?20% of the highest value in the direction perpendicular to processing, where, 0.05?n?0.

Abstract: The present invention relates to an apparatus for cooling a hot steel plate which is processed and constrained by constraining rolls and a method of arranging and setting spray nozzles enabling uniform cooling in a direction perpendicular to processing. In the apparatus and method of the invention, the spray nozzles are arranged so that a value of n power of the impact pressure of the cooling water on the cooling surface integrated in the processing direction between pairs of constraining rolls becomes within ?20% of the highest value in the direction perpendicular to processing, where 0.05?n?0.2.

Abstract: An apparatus for controlled cooling of hot steel plate while constraining and conveying the plate by constraining rolls horizontally which is inexpensive and enabling continuous control of the cooling ability over a broad range, that is, a cooling apparatus for spraying hot steel plate hot rolled and transferred between pairs of constraining rolls with cooling water from pluralities of lines of spray nozzles so as to cool the same, which apparatus has lines of gentle cooling spray nozzles and lines of strong cooling spray nozzles with different orifice shapes and enables continuous control of the cooling ability over a broad range due to the fact that a maximum cooling water impact pressure integrated value of the lines of gentle cooling spray nozzles and a minimum cooling water impact pressure integrated value of the lines of strong cooling spray nozzles are continuous.

Abstract: A game machine which uses play items such as cards and which enables the player to play a game seriously and to concentrate in the game so as to win over the opponent is provided according to the present invention. The game machine controls the progress of a game based on data read out from the play items, and issues a new play item for each game played. The game machine includes means for setting a game fee at a discount rate in accordance with the number of previous consecutive wins for the player to try a next post-victory bonus game after winning one game, and means for determining the number of games played based on the outcome (win or loss) of the player's previous games and for issuing new play items collectively to the player by the number corresponding to the determined number of games played.