Patents by Inventor Yasuhiro Ohba
Yasuhiro Ohba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150004414Abstract: Provided is a collagen structure characterized by: comprising collagen fibers of 1 to 5 ?m in average diameter; and has a water content of 0 to 15 (w/w)% and a collagen density of 50 to 800 mg/cm3. After generating collagen fibers by neutralizing an acidic collagen solution, the resulting solution is subjected to filtration or the like to form crude collagen fibers having a collagen concentration of 12 to 50 (w/v)%. The thus obtained crude collagen fibers are molded into a prescribed shape and then dried, thereby the collagen structure can be produced. Since the collagen structure is produced using, as raw material, collagen fibers that are formed by association of collagen molecules, the collagen structure has excellent cell infiltration property. Further, since the collagen density of the collagen structure is equivalent to that of in vivo collagen tissue, the collagen structure exhibits excellent tissue regeneration capacity when filled into a defective part in vivo.Type: ApplicationFiled: January 11, 2013Publication date: January 1, 2015Inventors: Takayuki Ogura, Keisuke Tanaka, Yasuhiro Ohba, Shunji Hattori
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Patent number: 5663373Abstract: Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: August 21, 1996Date of Patent: September 2, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
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Patent number: 5606089Abstract: Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: May 18, 1995Date of Patent: February 25, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
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Patent number: 5574178Abstract: Compounds represented by the general formula as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring.Type: GrantFiled: April 17, 1995Date of Patent: November 12, 1996Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kunio Tamura, Yoshiaki Kato, Mitsutaka Yoshida, Osamu Cynshi, Yasuhiro Ohba
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Patent number: 4578465Abstract: Phenylpiperazine derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group, and a process for producing the same are disclosed. The derivatives of the formula have alpha blocking and serotonin antagonizing activities and are useful as a drug.Type: GrantFiled: April 30, 1984Date of Patent: March 25, 1986Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Nagano, Mitiro Takagi, Noboru Kubodera, Isao Matsunaga, Hiroyuki Nabata, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Yasumi Uchida
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Patent number: 4560686Abstract: Compounds of the formula ##STR1## (wherein R.sub.1 is a lower alkyl group, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group or a lower alkoxycarbonyl group; two adjacent groups of R.sub.2, R.sub.3 and R.sub.4 may combine to form a methylenedioxy group; n is an integer of 2 to 6) or salts thereof, are disclosed.These compounds are useful as agents for treating circulatory diseases because they have hypotensive action and are capable of increasing the cerebral blood flow, decreasing the heart rate and suppressing ventricular arrhythmia due to myocardial ischemia.Type: GrantFiled: September 14, 1983Date of Patent: December 24, 1985Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Nagano, Mitiro Takagi, Noboru Kubodera, Isao Matsunaga, Hiroyuki Nabata, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Yasumi Uchida
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Patent number: 4415569Abstract: Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.Type: GrantFiled: December 17, 1981Date of Patent: November 15, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Fujimura Yasuo, Tanaka Sadao, Matsunaga Isao, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Minoru Shindo
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Patent number: 4409234Abstract: Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.Type: GrantFiled: June 3, 1982Date of Patent: October 11, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yasuo Fujimura, Sadao Tanaka, Isao Matsunaga, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Shun-ichi Hata, Minoru Shindo, Kazushige Sakai
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Patent number: 4379150Abstract: Dibenz[b,f][1,4]oxazepine derivatives of the formula ##STR1## (wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is a branched lower alkyl group; R.sub.3 is a hydrogen atom, a carboxyl group, a carbamoyl group, a lower alkoxycarbonyl group, or a lower alkoxy group; R.sub.4 and R.sub.5 are each a lower alkyl group or may, when taken together with a nitrogen atom, form a heterocyclic ring; and A is a lower alkylene group) or salts thereof, a process for preparing the same and pharmaceutical compositions comprising the same are disclosed. The derivatives of the formula above are effective to prevent and treat circulatory diseases, especially angina pectoris, and therefore, useful as medicines.Type: GrantFiled: December 17, 1981Date of Patent: April 5, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kiyohiko Ito, Masuo Koizumi, Yasushi Murakami, Michitaka Akima, Jinichiro Aono, Yasuhiro Ohba, Tamotsu Yamazaki, Kazushige Sakai, Shun-ichi Hata, Shigeru Takanashi
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Patent number: 4325562Abstract: A three-wheeled motor vehicle has a container for clothes and other things that is supported between a pair of channel-shaped bars extending rearwardly from the vehicle frame between a pair of rear wheels. The container has a pair of front resilient rollers disposed laterally thereof and fitted in a pair of respective channels fixed to and disposed in the channel-shaped bars, and a pair of rear resilient rollers fitted in the channel-shaped bars. The front resilient rollers are retained against forward movement by front vertical portions of the channels. The rear resilient rollers are retained against rearward movement by stop plates on a U-shaped guard fastened to the channel-shaped bars. The container is stably supported on the bars by the resilient rollers against vibrations and impacts.Type: GrantFiled: June 9, 1980Date of Patent: April 20, 1982Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Kozo Yamada, Yasuhiro Ohba, Seiichi Matsui
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Patent number: 3992029Abstract: A sport vehicle comprising a vehicle frame having a step on its upper surface and an upstanding handle rod at its front end. At the lower surface of the front of the frame a front wheel axle is mounted having a pair of front wheels at its ends, the middle portion of the axle being rotatably supported through a steering shaft having a negative caster angle, the vehicle frame and the front wheel axle being interconnected through a resilient member. A single rear wheel is mounted on the vehicle frame at the lower surface of the rear portion thereof. One of the three wheels can be a driving vehicle wheel in which case a pedal lever is swingably mounted on the frame for upwards and downwards movement to drive a longitudinally extending flexible member for reciprocation in forwardly and rearwardly direction.Type: GrantFiled: July 21, 1975Date of Patent: November 16, 1976Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Yoshikazu Washizawa, Kiyoshi Kume, Yasuhiro Ohba, Kazutoshi Otsuka
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Patent number: D267637Type: GrantFiled: November 7, 1980Date of Patent: January 18, 1983Assignee: Honda Giken Kogyo Kabushiki KaishaInventor: Yasuhiro Ohba
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Patent number: D267792Type: GrantFiled: June 26, 1981Date of Patent: February 1, 1983Assignee: Honda Giken Kogyo Kabushiki KaishaInventor: Yasuhiro Ohba
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Patent number: D268660Type: GrantFiled: July 23, 1980Date of Patent: April 19, 1983Assignee: Honda Giken Kogyo Kabushiki KaishaInventor: Yasuhiro Ohba
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Patent number: D276033Type: GrantFiled: July 26, 1982Date of Patent: October 23, 1984Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Yasuhiro Ohba, Mituru Yamamoto
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Patent number: D278044Type: GrantFiled: September 30, 1982Date of Patent: March 19, 1985Assignee: Honda Giken Kogyo Kabushiki KaishaInventor: Yasuhiro Ohba