Abstract: The present inventors administered a peptide derived from VEGFR-2, which is known as one of the proteins involved in neovascularization, to model mice (A2/Kb transgenic mice) expressing human HLA-A*0201, and tested whether or not the peptide has vaccine effect. As a result, the present inventors successfully discovered that vaccination using this peptide as an antigen is effective for inhibition of choroid neovascularization, and thereby completed the present invention. More specifically, the present invention provides vaccines for treatment and/or prevention of diseases caused by choroid neovascularization (neovascular maculopathy), which contain a VEGFR-2-derived peptide as an active ingredient.

Abstract: It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents —(O)n—R; R represents a C1-C6 alkyl group or the like; n represents 0 or 1; X represents O or the like; R2, R3 and R4 are independently selected from a hydrogen atom or C1-C3 alkyl; or R2 and R3 may join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.

Abstract: There is provided a composition comprising an RNA-encapsulated liposome, the RNA comprising a sequence being of 15 to 30 contiguous nucleotides of mRNA of a target gene associated with a disease in an eyeball, and a sequence complementary to the sequence, wherein the liposome is capable of reaching an eyeball, and the like. The liposome in which an RNA is encapsulated is, for example, a liposome composing a complex particle comprising a lead particle and the RNA as constituent components, the lead particle comprising a cationic lipid, and a bilayer lipid membrane for coating the complex particle. The bilayer lipid membrane is a bilayer lipid membrane comprising a neutral lipid, and a lipid derivative, a fatty acid derivative or an aliphatic hydrocarbon derivative of a water-soluble substance as constituent components.

Abstract: The invention is an optical fiber sheet obtained by adhering together at least two sheets with an optical fiber placed therebetween, and placing a reinforcing tube over a portion of the optical fiber extending from an edge of the sheets, wherein the reinforcing tube is fixed to the sheets by bonding, with the reinforcing tube inserted between the sheets located up and below by an appropriate distance from an edge of the sheets.

Abstract: In order to avoid a frequent multiple crossing in an optical fiber in a sheet and attach the optical connector near a marginal end of the sheet while maintaining a sufficient extra length and more extra length for attaching the optical fibers, in the optical fiber sheet 6, an optical fiber 5 as an extra length section in the optical fiber path is disposed on three-layer wiring planes which are formed by attaching four sheets 1, 2, 3, and 4. Notched sections 2a and 3a are formed in the intermediate layers 2 and 3. The optical fiber 5 communicates from a first wiring layer to a second wiring layer via the notched section 2a so as to communicate from the second wiring layer to a third wiring layer via the notched section 3a.

Abstract: An optical ferrule is disclosed in which a concave portion 17c having a gate G in resin molding disposed therein is formed in a ferrule body 11. According to this constitution, it is possible to easily cut a flash 10 left after a gate of the concave portion 17c of the ferrule body 11 is cut after molding with a gate cutter, so that, when the ferrule body 11 is fitted in a housing of an MPO connector and the like, the problem that the flash 10 protrudes from the concave portion 17c and the flash 10 hitching to an inner wall of the housing dose not occur. Accordingly, the labor required for removing the flash 10 by polishing can be eliminated, and hence productivity of the ferrule body 11 can be improved. Thus, a large number of ferrule bodies 11 can be automatically manufactured without requiring much manpower.

Abstract: An optical connector ferrule has an optical fiber containing hole reaching from the rear end surface near the end surface and a fine pore extending from the optical fiber accommodating hole to the end surface to be connected. A bare fiber of a polarization-maintaining optical fiber is inserted into the fine pore. Since the length of the fine pore is short, the influence of the uniformness of the adhesive in the fine pore is smaller, and therefore the stress distribution is maintained, resulting in stabilizing the polarization characteristics. A flange unit is attached to the ferrule after an optical fiber is inserted to the ferrule and fixed. Therefore the optical fiber is easily adjusted with respect to the housing in the circumferential direction around the axis, and optical fibers are connected by but joining with high accuracy.

Abstract: The current situation is such that it is difficult for drugs to reach posterior tissues of eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to positerior tissues of eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.

Abstract: In layout design of a semiconductor device including a device forming region formed on a substrate; an isolation region formed on the semiconductor substrate so as to surround the device forming region; a gate electrode formed on the device forming region; and a gate interconnect connected to the gate electrode and formed on both sides of the device forming region on the isolation region, the semiconductor device is designed as follows: The gate interconnect has a first portion with a larger dimension along the gate length direction than the gate electrode on one side of the device forming region and has a second portion with a larger dimension along the gate length direction than the gate electrode on the other side of the device forming region; and a distance between the first portion and the device forming region is equal to a distance between the second portion and the device forming region.

Abstract: The current situation is such that it is difficult for drugs to reach posterior tissues of an eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to positerior tissues of the eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.

Abstract: In a semiconductor integrated circuit design method for simulating a delay of a logic circuit based on delay values which are calculated for each kind of a plurality of cells composing the logic circuit or for each signal path of the logic circuit and which are stored in a delay library, the simulation is performed to a block including at least one cell, and a delay value varying dependent on a layout direction of the cell included in the block is used as the delay value in the delay library. By this method, timing verification can be performed according to the layout direction of each cell layouted on a wafer, attaining precise margin of the design and improving yield of the semiconductor integrated circuit.

Abstract: An optical connector ferrule has an optical fiber containing hole reaching from the rear end surface near the end surface and a fine pore extending from the optical fiber accommodating hole to the end surface to be connected. A bare fiber of a polarization-maintaining optical fiber is inserted into the fine pore. Since the length of the fine pore is short, the influence of the uniformness of the adhesive in the fine pore is smaller, and therefore the stress distribution is maintained, resulting in stabilizing the polarization characteristics. A flange unit is attached to the ferrule after an optical fiber is inserted to the ferrule and fixed. Therefore the optical fiber is easily adjusted with respect to the housing in the circumferential direction around the axis, and optical fibers are connected by but joining with high accuracy.

Abstract: The invention is an optical fiber sheet obtained by adhering together at least two sheets with an optical fiber placed therebetween, and placing a reinforcing tube over a portion of the optical fiber extending from an edge of the sheets, wherein the reinforcing tube is fixed to the sheets by bonding, with the reinforcing tube inserted between the sheets located up and below by an appropriate distance from an edge of the sheets.

Abstract: The present invention is applied to a structure in which to attach a backplane connector to a backplane so that the backplane connector can be moved by a desired amount, a clip from which a pair of elastic pawls project is used to engage the backplane with the backplane connector through holes in the backplane. The present invention allows the clip of this structure to be removed efficiently. That is, the present invention provides a clip removing tool 50 comprising disengaging pieces 52a and 52b that push in a pair of elastic pawls 29b through an attaching slot 31 in a backplane 23, the elastic pawls 29b being engaged with locking portions 34 on opposite side portions of a BH housing 26 are pushed, to disengage the elastic pawls 29b from the locking portions 34, as well as a clip removing method using this clip removing tool.

Abstract: In order to avoid a frequent multiple crossing in an optical fiber in a sheet and attach the optical connector near a marginal end of the sheet while maintaining a sufficient extra length and more extra length for attaching the optical fibers, in the optical fiber sheet 6, an optical fiber 5 as an extra length section in the optical fiber path is disposed on three-layer wiring planes which are formed by attaching four sheets 1, 2, 3, and 4. Notched sections 2a and 3a are formed in the intermediate layers 2 and 3. The optical fiber 5 communicates from a first wiring layer to a second wiring layer via the notched section 2a so as to communicate from the second wiring layer to a third wiring layer via the notched section 3a.

Abstract: The present invention is applied to a structure in which to attach a backplane connector to a backplane so that the backplane connector can be moved by a desired amount, a clip from which a pair of elastic pawls project is used to engage the backplane with the backplane connector through holes in the backplane. The present invention allows the clip of this structure to be removed efficiently. That is, the present invention provides a clip removing tool 50 comprising disengaging pieces 52a and 52b that push in a pair of elastic pawls 29b through an attaching slot 31 in a backplane 23, the elastic pawls 29b being engaged with locking portions 34 on opposite side portions of a BH housing 26 are pushed, to disengage the elastic pawls 29b from the locking portions 34, as well as a clip removing method using this clip removing tool.

Abstract: In an optical connector structured having an optical connector ferrule accommodated in a housing urged towards the butt connection direction by an urging means, a technology is developed wherein the application of an external sideways force to the optical connector ferrule in a connected state is prevented, and the connected state is stably maintained. An optical connector 20 is provided wherein a positioning support part 24 which accommodates and supports a freely detachably a stop guard 26, which projects from the optical fiber ferrule 2, is provided in a housing 21; when this optical connector ferrule 2 is moved towards the butt connection direction, the stop guard is accommodated in the positioning support part 24 and positioned and supported; and when this stop guard 26 is released from the positioning support part 24, floating of the optical connector ferrule 2 in the housing 2 is permitted.

Abstract: A closure for cable connection which is capable of preventing deformation thereof, facilitating incorporation and setting of a cable therein, exhibiting increased safety and airtightness, and attaining sleeve assembling and cable connection with improved workability. A sleeve is provided therein with a cable connection mechanism including a cable clamp, a tension member holder, and a fiber cable storage casing in which a fiber connection section of cable fibers and an excessive fiber are received. The sleeve is provided on upper and lower portions of an inner surface thereof with connection fitment mounting sections, on which a frame-like connection fitment for mounting the cable connection mechanism thereon is detachably fittedly fixed.

Abstract: An optical fiber device 10 characterized in comprising a support mechanism 11 that supports an optical fiber connector 1 having components 2 with a two piece structure disposed one over the other and held against each other by a tension means, and at one end or the other end of which one or the other optical fibers 3,3 is inserted between said components, determining the alignment position so as to be able to connect optical fibers end to end, a separation member 20 releasing said optical fibers by spreading in the direction of separation of said components by opposing the tension of said tension means when inserted into said components from a direction straight along the longitudinal direction of said optical connector, and a push pressure device 30 which inserts said separation member between said components by applying pushing pressure in the direction of the optical connector to said seperator, and while applying end to end force to both optical fibers end to end in the component, closes the component, an

Abstract: Development of a multiple-core optical connector which can make multiple-core or a plurality of optical fibers connected in a simple manner has been sought. There are provided an optical connector ferrule for internally fixing beforehand the optical fibers arranged in parallel on an identical plane and having joining end surface of a tip which is polished, and an optical connector which is furnished with a connecting mechanism for maintaining a connected state by holding aforementioned optical connector which protrudes from the rear end, facing the aforementioned joining end surface of the aforementioned connector ferrule and a separate optical fiber connected by abutting against the optical fiber of the optical connector ferrule side.