Patents by Inventor Yasuhiro Zaima
Yasuhiro Zaima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230103250Abstract: There is provided a pharmaceutical composition comprising lemborexant exhibiting a favorable dissolution profile by using a granular material having a 90% cumulative diameter (D90) of 64 ?m or less as a lemborexant active pharmaceutical ingredient.Type: ApplicationFiled: January 14, 2021Publication date: March 30, 2023Inventors: Taichi ABE, Yusuke AYATA, Nobuya SUZUKI, Yurie AKIMOTO, Futoshi SHIKATA, Yasuhiro Zaima, Nobuo YOSHIDA
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Patent number: 11026944Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.Type: GrantFiled: March 16, 2020Date of Patent: June 8, 2021Assignee: Eisai R&D Management Co., Ltd.Inventors: Margaret Moline, Gina Pastino, Yurie Akimoto, Yasuhiro Zaima, Nobuya Suzuki, Nobuo Yoshida
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Publication number: 20200268754Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.Type: ApplicationFiled: March 16, 2020Publication date: August 27, 2020Applicant: Eisai R&D Management Co., Ltd.Inventors: Margaret MOLINE, Gina PASTINO, Yurie AKIMOTO, Yasuhiro ZAIMA, Nobuya SUZUKI, Nobuo YOSHIDA
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Patent number: 10702529Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.Type: GrantFiled: January 23, 2019Date of Patent: July 7, 2020Assignee: Eisai R&D Management Co., Ltd.Inventors: Margaret Moline, Gina Pastino, Yurie Akimoto, Yasuhiro Zaima, Nobuya Suzuki, Nobuo Yoshida
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Publication number: 20190201399Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.Type: ApplicationFiled: January 23, 2019Publication date: July 4, 2019Applicant: Eisai R&D Management Co., Ltd.Inventors: Margaret MOLINE, Gina PASTINO, Yurie AKIMOTO, Yasuhiro ZAIMA, Nobuya SUZUKI, Nobuo YOSHIDA
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Patent number: 10188652Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.Type: GrantFiled: October 21, 2015Date of Patent: January 29, 2019Assignee: Eisai R&D Management Co., Ltd.Inventors: Margaret Moline, Gina Pastino, Yurie Akimoto, Yasuhiro Zaima, Nobuya Suzuki, Nobuo Yoshida
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Patent number: 10117876Abstract: The present invention provides a pharmaceutical composition comprising a compound represented by formula (1): or N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d] [1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide, or a pharmaceutically acceptable salt of the foregoing, and a salt of a compound having a C12-22 saturated aliphatic hydrocarbon group.Type: GrantFiled: October 8, 2015Date of Patent: November 6, 2018Assignee: Eisai R&D Management Co., Ltd.Inventors: Yasuhiro Zaima, Kazuo Kazama, Shuntaro Arase, Kentaro Nagane, Kanta Horie, Yosuke Ueki
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Publication number: 20180263998Abstract: The present invention provides a pharmaceutical composition comprising a compound represented by formula (1): or N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide, or a pharmaceutically acceptable salt of the foregoing, and a salt of a compound having a C12-22 saturated aliphatic hydrocarbon group.Type: ApplicationFiled: October 8, 2015Publication date: September 20, 2018Applicant: Eisai R&D Management Co., Ltd.Inventors: Yasuhiro Zaima, Kazuo Kazama, Shuntaro Arase, Kentaro Nagane, Kanta Horie, Yosuke Ueki
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Patent number: 10076524Abstract: The present invention provides a pharmaceutical composition comprising a compound represented by formula (1): or N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d] [1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide, or a pharmaceutically acceptable salt of the foregoing, and a salt of a compound having a C12-22 saturated aliphatic hydrocarbon group.Type: GrantFiled: October 8, 2015Date of Patent: September 18, 2018Assignee: Eisai R&D Management Co., Ltd.Inventors: Yasuhiro Zaima, Kazuo Kazama, Shuntaro Arase, Kentaro Nagane, Kanta Horie, Yosuke Ueki
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Publication number: 20170252342Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.Type: ApplicationFiled: October 21, 2015Publication date: September 7, 2017Applicant: Eisai R&D Management Co., Ltd.Inventors: Margaret MOLINE, Gina PASTINO, Yurie AKIMOTO, Yasuhiro ZAIMA, Nobuya SUZUKI, Nobuo YOSHIDA
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Publication number: 20100105738Abstract: The invention provides extended release formulations of proton pump inhibitor, such as an extended release formulation of rabeprazole, comprising an amount of rabeprazole between 30 and 90 mg rabeprazole and having an AUC of between 900 and 1750 ng*hr/mL and other properties.Type: ApplicationFiled: October 4, 2007Publication date: April 29, 2010Inventors: Mitsuru Mizuno, Shigeru Aoki, Kiyoshi Iwamoto, Kenji Moroshima, Yasuhiro Zaima, Manabu Murakami, Yukio Horai, Takashi Seno, Norihiro Ueda
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Publication number: 20100009003Abstract: The present invention provides a pharmaceutical preparation to be dispersed before administration which has an adequate viscosity and a suitable flowability even when dispersed in a small amount of water and can be easily administered through an NG tube is provided. Specifically, the pharmaceutical preparation to be dispersed before administration contains active granules containing a pharmaceutically active substance having an average particle diameter of 5 mm or less and a thickening agent, and can be administered through an NG tube by dispersing in water before administration.Type: ApplicationFiled: September 17, 2009Publication date: January 14, 2010Inventors: Koji UKAI, Yasuyuki Asai, Yoshiteru Kato, Takayuki Ohwaki, Shigeru Aoki, Yasuhiro Zaima, Takehiro Yamaguchi
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Patent number: 7611078Abstract: Parts of a powdered medicine multi-dose administering device are assembled, powdered medicine is filled and assembly that is obtained is inspected all on an automatic production line to increase productivity while preventing the production of defective products. The powdered medicine multi-dose administering device is produced through automated steps of inserting a filter (12) in a filter-fitting portion (11a) of a container (10), inserting an inner cylinder (15) in the container body (10), filling the container with the powdered medicine through a ring-like opening between an opening in the upper part of the container and the inner cylinder, fitting an inner closure (19) to the container and to the inner cylinder, fitting a nozzle (20) to the container while coupling it to the inner cylinder, and inspecting the thus obtained assembly.Type: GrantFiled: March 16, 2004Date of Patent: November 3, 2009Assignee: Teijin LimitedInventors: Yasuhiro Zaima, Masahiko Dohi, Seiji Mochizuki, Hiroshi Kuroda
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Publication number: 20090148519Abstract: An object of the present invention is to provide a pulsed-release preparation that achieves pulsed-release by coating the exterior of a core that contains a physiologically active substance and a disintegrant, with a controlled-release coating that contains a water-insoluble polymer and an enteric polymer, or a water-insoluble polymer and a water-soluble polymer, wherein a satisfactory pulsed-release can be achieved without increasing the amount of disintegrant in the core, in particular even in the low-water environment in the lower part of the digestive tract. The present invention provides a pulsed-release preparation comprising: 1) a core containing a physiologically active substance and a disintegrant; 2) an enteric coating that covers the core; and 3) a controlled-release coating that covers the enteric coating applied on the core and that contains a water-insoluble polymer and an enteric polymer or water-soluble polymer.Type: ApplicationFiled: September 27, 2006Publication date: June 11, 2009Inventors: Yasuhiro Zaima, Takayuki Owaki
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Publication number: 20090123665Abstract: The present invention provides a fluidized bed device for handling fine particles as a fluidized bed in a medicine manufacturing process, a cosmetic manufacturing process, a food manufacturing process, a chemical manufacturing process and the like, wherein influence of static electricity is suppressed, and a method for neutralizing the static electricity using that device. The fluidized bed device includes an X-ray irradiation unit for irradiating fine particles in the fluidized bed device with X-rays.Type: ApplicationFiled: December 21, 2005Publication date: May 14, 2009Inventor: Yasuhiro Zaima
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Patent number: 7119288Abstract: A method of weighing an easily chargeable measured object able to remove the effects of static electricity to weigh a measured object by an accuracy of about 0.3 mg continuously with a good work efficiency. When using an electronic scale (10) provided with a weighing platform (11) and a weighing pan (12) able to move vertically by a very small distance with respect to the weighing platform to weight an easily chargeable measured object (14), the measured object is weighed in the state with a conductive frame (13) of a suitable size set on the weighing platform (11) around the weighing pan so as to surround the measured object placed on the weighing pan.Type: GrantFiled: July 17, 2003Date of Patent: October 10, 2006Assignee: Teijin LimitedInventors: Yasuhiro Zaima, Masahiko Dohi, Seiji Mochizuki, Akemi Kitada
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Publication number: 20050123021Abstract: A method of weighing an easily chargeable measured object able to remove the effects of static electricity to weigh a measured object by an accuracy of about 0.3 mg continuously with a good work efficiency. When using an electronic scale (10) provided with a weighing platform (11) and a weighing pan (12) able to move vertically by a very small distance with respect to the weighing platform to weight an easily chargeable measured object (14), the measured object is weighed in the state with a conductive frame (13) of a suitable size set on the weighing platform (11) around the weighing pan so as to surround the measured object placed on the weighing pan.Type: ApplicationFiled: July 17, 2003Publication date: June 9, 2005Inventors: Yasuhiro Zaima, Masahiko Dohi, Seiji Mochizuki, Akemi Kitada
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Publication number: 20040237276Abstract: Parts of a powdered medicine multi-dose administering device are assembled, powdered medicine is filled and assembly that is obtained is inspected all on an automatic production line to increase productivity while preventing the production of defective products. The powdered medicine multi-dose administering device is produced through automated steps of inserting a filter (12) in a filter-fitting portion (11a) of a container (10), inserting an inner cylinder (15) in the container body (10), filling the container with the powdered medicine through a ring-like opening between an opening in the upper part of the container and the inner cylinder, fitting an inner closure (19) to the container and to the inner cylinder, fitting a nozzle (20) to the container while coupling it to the inner cylinder, and inspecting the thus obtained assembly.Type: ApplicationFiled: March 16, 2004Publication date: December 2, 2004Inventors: Yasuhiro Zaima, Masahiko Dohi, Seiji Mochizuki, Hiroshi Kuroda