Patents by Inventor Yasuhisa Sakurai
Yasuhisa Sakurai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7760925Abstract: In a method for automatically detecting degenerated regions in many stained thin section specimens (40), color region information is obtained on a degenerated region and on a non-degenerated region on image data of a standard specimen in a stained thin section slide. Next, color region information is obtained on a non-degenerated region on image data of a specimen. Next, the image data of the specimen is compared with the image data of the standard specimen to calculate a color correction quantity to match tone and brightness of the non-degenerated region in the specimen with the counterparts in the non-degenerated region in the standard specimen, and the image data of the specimen is corrected with the color correction quantity. Next, a degenerated region is extracted in the corrected image data of the specimen based on the color region information in the standard specimen.Type: GrantFiled: March 16, 2005Date of Patent: July 20, 2010Assignees: Kurashiki Boseki Kabushiki Kaisha, Osaka Bioscience InstituteInventors: Yasuhisa Sakurai, Hideaki Hikawa, Shuuichi Taneda, Naomi Eguchi
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Publication number: 20080159603Abstract: In a method for automatically detecting degenerated regions in many stained thin section specimens (40), color region information is obtained on a degenerated region and on a non-degenerated region on image data of a standard specimen in a stained thin section slide. Next, color region information is obtained on a non-degenerated region on image data of a specimen. Next, the image data of the specimen is compared with the image data of the standard specimen to calculate a color correction quantity to match tone and brightness of the non-degenerated region in the specimen with the counterparts in the non-degenerated region in the standard specimen, and the image data of the specimen is corrected with the color correction quantity. Next, a degenerated region is extracted in the corrected image data of the specimen based on the color region information in the standard specimen.Type: ApplicationFiled: March 16, 2005Publication date: July 3, 2008Applicant: Kurashiki Boseki Kabushiki KaishaInventors: Yasuhisa Sakurai, Hideaki Hikawa, Shuuichi Taneda, Naomi Eguchi
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Publication number: 20060025330Abstract: The present invention provides an electrostatic bonding macromolecular micelle drug carrier comprising a block copolymer having a non-chargeable segment and a chargeable segment, for stably carrying a chargeable drug tending to be easily decomposed in vivo such as protein and DNA.Type: ApplicationFiled: September 21, 2005Publication date: February 2, 2006Inventors: Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka, Masayuki Yokoyama, Satoshi Katayose, Satoru Suwa, Atsushi Harada
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Patent number: 6706187Abstract: To provide chromatographic packings whereby biological components, etc. which cannot be separated by either ion-exchange chromatography or reversed phase chromatography employed alone can be efficiently separated without deteriorating their activities. Use is made of a packing which contains a charged copolymer and makes it possible to change the effective charge density on the surface of a stationary phase by a physical stimulus while fixing a mobile phase to an aqueous system.Type: GrantFiled: January 19, 2001Date of Patent: March 16, 2004Inventors: Teruo Okano, Akihiko Kikuchi, Yasuhisa Sakurai, Hideko Kanazawa, Yoshikazu Matsushima
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Publication number: 20020082198Abstract: The present invention provides an electrostatic bonding macromolecular micelle drug carrier comprising a block copolymer having a non-chargeable segment and a chargeable segment, for stably carrying a chargeable drug tending to be easily decomposed in vivo such as protein and DNA.Type: ApplicationFiled: February 27, 2002Publication date: June 27, 2002Inventors: Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka, Masayuki Yokoyama, Satoshi Katayose, Satoru Suwa, Atsushi Harada
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Patent number: 6372141Abstract: PTH-amino acids can be analyzed within a short time at a high sensitivity by chromatographically separating said PTH-amino acids with the use of a packing wherein the hydrophilic/hydrophobic balance on the stationary phase surface can be changed by an external signal while fixing the mobile phase to an aqueous system.Type: GrantFiled: September 10, 1999Date of Patent: April 16, 2002Assignee: Amersham Pharmacia Biotech K.K.Inventors: Teruo Okano, Akihiko Kikuchi, Yasuhisa Sakurai, Hideko Kanazawa, Yoshikazu Matsushima
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Patent number: 6294614Abstract: Modified polymers containing a poly(2-hydroxyethyl(meth)acrylate) chain as the hydrophilic polymer segment in which a hydrophobic polymer chain or a lipid residue of a sterol is bound to either end of the poly(2-hydroxyethyl(meth)acrylate) chain through a covalent bond or in which the poly(2-hydroxyethyl(meth)acrylate) chain is grafted onto the backbone chain at either end thereof. These modified polymers are excellent in compatibility with liquid or a living body, thus being advantageously usable particularly in medical fields.Type: GrantFiled: January 27, 1999Date of Patent: September 25, 2001Assignee: K. K. VayuInventors: Kazunori Kataoka, Masao Kato, Yukio Nagasaki, Hotaka Ito, Teiji Tsuruta, Yasuhisa Sakurai, Teruo Okano, Ken Suzuki
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Publication number: 20010000510Abstract: The present invention provides an electrostatic bonding type macromolecular micell drug carrier comprising a block copolymer having a non-chargeable segment and a chargeable segment, for stably carrying a chargeable drug tending to be easily decomposedin vivo such as protein and DNA.Type: ApplicationFiled: December 5, 2000Publication date: April 26, 2001Inventors: Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka, Masayuki Yokoyama, Satoshi Katayose, Satoru Suwa, Atsushi Harada
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Patent number: 6080396Abstract: A dimer, trimer or tetramer of an anthracycline compound which can be obtained by directly, chemically bonding anthracycline compounds having anticancer activities to each other by an alkali treatment. A high molecular block copolymer-drug complex pharmaceutical preparation in which the high molecular block copolymer having a hydrophilic polymer segment and a hydrophobic polymer segment forms a micelle having the hydrophilic segment as its outer shell and contains in its hydrophobic inner core a dimer, trimer or tetramer of anthracycline compound alone or together with other drugs.Type: GrantFiled: August 18, 1997Date of Patent: June 27, 2000Assignees: Japan Science and Technology Corporation, Yasuhisa Sakurai, Nippon Kayaku Kabushiki KaishaInventors: Masayuki Yokoyama, Kazunori Kataoka, Teruo Okano, Yasuhisa Sakurai, Shigeto Fukushima, Ryuji Uehara, Tomoko Akutsu, Kazuya Okamoto, Hiroko Mashiba, Megumi Machida, Kazuhisa Shimizu
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Patent number: 5693751Abstract: This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded.The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on.The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof.Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.Type: GrantFiled: March 8, 1995Date of Patent: December 2, 1997Assignee: Research Development Corporation of JapanInventors: Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka, Noriko Yamada, Shohei Inoue, Masayuki Yokoyama
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Patent number: 5679765Abstract: The present invention relates to a bifunctional polyether having groups different from each other at both ends, with a polymerization degree of 5 to 10000 and consisting of repeating units each represented by the following formula (I): ##STR1## (wherein R.sub.1, represents a hydrogen atom, halogen atom, or a lower alkyl group optionally substituted by a halogen atom, and R.sub.1 in each repeating unit may be the same or different), as well as to a process for the preparation thereof and a polymerization initiator therefor. The process of production and polymerization initiator of the present invention enable 100% introduction of a primary amino group into one of the ends of polyether.Type: GrantFiled: July 16, 1996Date of Patent: October 21, 1997Assignee: Research Development Corporation of JapanInventors: Yasuhisa Sakurai, Teruo Okano, Masayuki Yokoyama, Kazunori Kataoka, Yukio Nagasaki, Nobuyuki Ohsako, Masao Kato
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Patent number: 5510103Abstract: The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.Type: GrantFiled: June 5, 1995Date of Patent: April 23, 1996Assignee: Research Development Corporation of JapanInventors: Masayuki Yokoyama, Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka
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Patent number: 5483008Abstract: The present invention relates to a bifunctional polyether having groups different from each other at both ends, with a polymerization degree of 5 to 10000 and consisting of repeating units each represented by the following formula (I): ##STR1## (wherein R.sub.1, represents a hydrogen atom, halogen atom, or a lower alkyl group optionally substituted by a halogen atom, and R.sub.1 in each repeating unit may be the same or different), as well as to a process for the preparation thereof and a polymerization initiator therefor. The process of production and polymerization initiator of the present invention enable 100% introduction of a primary amino group into one of the ends of polyether.Type: GrantFiled: February 5, 1993Date of Patent: January 9, 1996Assignee: Research Development Corporation of JapanInventors: Yasuhisa Sakurai, Teruo Okano, Masayuki Yokoyama, Kazunori Kataoka, Yukio Nagasaki, Nobuyuki Ohsako, Masao Kato
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Patent number: 5478575Abstract: The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.Type: GrantFiled: March 26, 1993Date of Patent: December 26, 1995Assignee: Nippon Oil & Fats Co., Ltd.Inventors: Tsuyoshi Miyazaki, Yoshishige Murata, Daijiro Shiino, Kazunori Waki, Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka, Yoshiyuki Koyama, Masayuki Yokoyama, Shigeru Kitano
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Patent number: 5449513Abstract: The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.Type: GrantFiled: August 11, 1993Date of Patent: September 12, 1995Assignee: Research Development Corporation of JapanInventors: Masayuki Yokoyama, Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka
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Patent number: 5412072Abstract: This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded. The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on. The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof. Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.Type: GrantFiled: March 21, 1990Date of Patent: May 2, 1995Assignee: Research Development Corp. of JapanInventors: Yasuhisa Sakurai, Teruo Okano, Kazunori Kataoka, Noriko Yamada, Shohei Inoue, Masayuki Yokoyama
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Patent number: 5284766Abstract: Disclosed is a bed material whereby cultured or grown cells are collected or detached from the material without a proteolysis enzyme or chemical material. The bed material comprises a support and a coating thereon, wherein the coating is formed from a polymer or copolymer which has a critical solution temperature to water within the range of 0.degree. C. to 80.degree. C.Type: GrantFiled: January 7, 1992Date of Patent: February 8, 1994Assignees: Kao Corporation, Tokyo Women's Medical CollegeInventors: Teruo Okano, Kazunori Kataoka, Noriko Yamada, Yasuhisa Sakurai, Takayuki Amiya, Akira Mamada
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Patent number: 5243293Abstract: A system for detecting a fault occurred within a substation and judging a location of the fault including optical current sensors each having a Faraday element arranged on a top of an insulator post of a bus disconnecting switch, a magnetic core arranged to surround a terminal plate of the disconnecting switch to generate a magnetic field corresponding to a current passing through the terminal plate, a laser diode for emitting a laser light beam, an optical fiber for guiding the laser beam to the Faraday element, a photodiode, and an optical fiber for guiding the laser beam transmitted through the Faraday element to the photodiode. The photodiode supplies a signal representing the current passing through the terminal plate to a fault location judging circuit in which the fault location within the substation is judged from the signals from the photodiodes.Type: GrantFiled: May 26, 1989Date of Patent: September 7, 1993Assignee: NGK Insulators, Ltd.Inventors: Takashi Isozaki, Katsuro Shinoda, Toshiyuki Kawaguchi, Hiroyuki Katsukawa, Kazumi Nakanishi, Hiroyuki Abe, Yasuhisa Sakurai
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Patent number: 5202812Abstract: In a system for transmitting an electrical power supply by means of an over-head power transmission line supported by power transmission towers, a fault such as a short-circuit fault and a ground fault is detected by providing optical current sensors having opto-magnetic elements and opto-electric field elements on respective conductors of the transmission line to detect a fault current and fault voltage on the basis of the Faraday's effect and Pockel's effect. Light beams passing through the elements are modulated by the magnetic fields induced by the currents passing through the conductors and the voltages on the conductors, and thus include information about the current and voltage. There is further provided a circuit for calculating a distance to a fault point in accordance with the detected current, voltage and a phase difference therebetween and a known impedance of the power transmission line.Type: GrantFiled: September 14, 1989Date of Patent: April 13, 1993Assignee: NGK Insulators, Ltd.Inventors: Katsuro Shinoda, Toshiyuki Kawaguchi, Hiroyuki Katsukawa, Genzo Kimura, Naoki Tanaka, Hiroyuki Abe, Yasuhisa Sakurai
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Patent number: 4873292Abstract: An antithrombogenic synthetic polymer has repeat structural units represented by the following structural formula consisting of portions I and II: ##STR1## a microdomain structure composed of crystalline phases and amorphous phases, each phase having an average size of 5 to 10 nm, and a molecular weight in the range of about 10,000 to about 300,000. The polymer exhibits little adhesion of blood platelets thereto, an excellent antithrombogenic property and a sufficient mechanical strength.Type: GrantFiled: February 9, 1988Date of Patent: October 10, 1989Assignee: Research Development Corporation of JapanInventors: Naoya Ogata, Kohei Sanui, Nobuhiko Yui, Kazunori Kataoka, Teruo Okano, Yasuhisa Sakurai