Patents by Inventor Yasuki Kato
Yasuki Kato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11071639Abstract: A brace includes a first member, a second member, a joint mechanism, and an insertion-fitting member configured to be insertion-fitted into the joint mechanism in such a manner that the insertion-fitting member can be fixed to and removed from the joint mechanism; the joint mechanism includes an insertion-fitting receiving part, the insertion-fitting receiving part being configured to enable the insertion-fitting member to be insertion-fitted into the joint mechanism, and a regulation part being disposed around the rotation axis in the second member; and the regulation part, which rotates around the rotation axis in an integrated manner with a rotation of the second member, comes into contact with the insertion-fitting member fixed to the insertion-fitting receiving part on a trajectory of the rotation of the regulation part, so that a range of the rotation of the second member is regulated.Type: GrantFiled: March 26, 2018Date of Patent: July 27, 2021Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Yoshinori Fujikake, Yasuki Kato
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Patent number: 11020418Abstract: A unit structure-type pharmaceutical composition includes a single nucleic acid, such as an antisense nucleic acid, electrostatically bound to a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charges of the nucleic acid are counterbalanced, at least substantially, by the positive charges of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment. The block copolymer thereby improves the blood retention capability of the nucleic acids.Type: GrantFiled: October 5, 2017Date of Patent: June 1, 2021Assignees: NANOCARRIER CO., LTD., THE UNIVERSITY OF TOKYOInventors: Kazunori Kataoka, Kanjiro Miyata, Nobuhiro Nishiyama, Kensuke Osada, Sumiyo Watanabe, Shigeto Fukushima, Hiroyuki Chaya, Hiroyasu Takemoto, Yasuki Kato
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Publication number: 20200000688Abstract: A polymeric micelle carrier composition contains i) a block copolymer having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; ii) a charged surfactant; and iii) a fatty oil. The carrier composition can be utilized as a base material of a cosmetic composition or a pharmaceutical composition and excels in loadability of non-lipophilic drugs. One example of a non-lipophilic drug is a hair growth promoting peptide.Type: ApplicationFiled: September 9, 2019Publication date: January 2, 2020Inventors: Kenta ISHII, Yasuki KATO
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Publication number: 20180289523Abstract: A brace includes a first member, a second member, a joint mechanism, and an insertion-fitting member configured to be insertion-fitted into the joint mechanism in such a manner that the insertion-fitting member can be fixed to and removed from the joint mechanism; the joint mechanism includes an insertion-fitting receiving part, the insertion-fitting receiving part being configured to enable the insertion-fitting member to be insertion-fitted into the joint mechanism, and a regulation part being disposed around the rotation axis in the second member; and the regulation part, which rotates around the rotation axis in an integrated manner with a rotation of the second member, comes into contact with the insertion-fitting member fixed to the insertion-fitting receiving part on a trajectory of the rotation of the regulation part, so that a range of the rotation of the second member is regulated.Type: ApplicationFiled: March 26, 2018Publication date: October 11, 2018Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Yoshinori FUJIKAKE, Yasuki KATO
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Publication number: 20180153920Abstract: A unit structure consists of a single nucleic acid having a length of 10 to 30 bases, and a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. In this unit structure: (i) a difference between a total of positive charges derived from cationic groups of the cationic polyamino acid segment and a total of negative charges derived from the nucleic acid in the unit structure falls within a range of ±10% of the total of the negative charges derived from the nucleic acid, (ii) the hydrophilic polymer chain segment comprises polyethylene glycol, (iii) the polyethylene glycol has a radius of inertia (Rg) equal to or longer than the length of the nucleic acid, and (iv) the cationic polyamino acid segment is bound to the nucleic acid via electrostatic bonds.Type: ApplicationFiled: January 25, 2018Publication date: June 7, 2018Inventors: Kazunori KATAOKA, Kanjiro MIYATA, Nobuhiro NISHIYAMA, Kensuke OSADA, Sumiyo WATANABE, Shigeto FUKUSHIMA, Hiroyuki CHAYA, Hiroyasu TAKEMOTO, Yasuki KATO
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Patent number: 9920133Abstract: Monoclonal antibodies against human and mouse tissue factor, and fragments thereof, are disclosed, as well as pharmaceutical compositions and compositions for drug delivery containing the same. Therapeutic methods using the same are also disclosed.Type: GrantFiled: February 3, 2015Date of Patent: March 20, 2018Assignees: NATIONAL CANCER CENTER, The University of Tokyo, RIKEN, NanoCarrier Co., Ltd.Inventors: Yasuhiro Matsumura, Masahiro Yasunaga, Yoshikatsu Koga, Yoshiyuki Yamamoto, Ryuta Sato, Ryo Tsumura, Kazunori Kataoka, Nobuhiro Nishiyama, Yutaka Miura, Shino Manabe, Yasuki Kato
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Publication number: 20180071199Abstract: A polymer treatment agent for rehabilitating damaged hair contains a block copolymer including a hydrophilic polymer chain segment and a hydrophobic polymer chain segment that is derived from a polyamino acid. The polymer treatment agent is not limited to methods for rehabilitating damaged head hair, but also can be applied to body hair including eyelashes and eyebrows; furthermore, it can increase the physical strength of hair even when applied in a very small amount and without using a silicone component.Type: ApplicationFiled: February 29, 2016Publication date: March 15, 2018Inventors: Kenta ISHII, Miho KOKUBO, Ichiro NAKATOMI, Yasuki KATO, Sakiko KATO
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Publication number: 20180042955Abstract: A unit structure-type pharmaceutical composition includes a single nucleic acid, such as an antisense nucleic acid, electrostatically bound to a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charges of the nucleic acid are counterbalanced, at least substantially, by the positive charges of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment. The block copolymer thereby improves the blood retention capability of the nucleic acids.Type: ApplicationFiled: October 5, 2017Publication date: February 15, 2018Inventors: Kazunori KATAOKA, Kanjiro MIYATA, Nobuhiro NISHIYAMA, Kensuke OSADA, Sumiyo WATANABE, Shigeto FUKUSHIMA, Hiroyuki CHAYA, Hiroyasu TAKEMOTO, Yasuki KATO
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Publication number: 20180015007Abstract: A polymeric micelle carrier composition contains i) a block copolymer having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; ii) a charged surfactant; and iii) a fatty oil. The carrier composition can be utilized as a base material of a cosmetic composition or a pharmaceutical composition and excels in loadability of non-lipophilic drugs. One example of a non-lipophilic drug is a hair growth promoting peptide.Type: ApplicationFiled: February 29, 2016Publication date: January 18, 2018Applicant: NanoCarrier Co., Ltd.Inventors: Kenta ISHII, Yasuki KATO
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Patent number: 9808480Abstract: A unit structure-type pharmaceutical composition includes at least one nucleic acid, such as siRNA, electrostatically bound to at least one block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charge(s) of the nucleic acid are counterbalanced, at least substantially, by the positive charge(s) of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment(s). The at least one block copolymer thereby improves the blood retention capability of the nucleic acid(s).Type: GrantFiled: April 30, 2013Date of Patent: November 7, 2017Assignees: NANOCARRIER CO., LTD., THE UNIVERSITY OF TOKYOInventors: Kazunori Kataoka, Kanjiro Miyata, Nobuhiro Nishiyama, Kensuke Osada, Sumiyo Watanabe, Shigeto Fukushima, Hiroyuki Chaya, Hiroyasu Takemoto, Yasuki Kato
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Patent number: 9795563Abstract: The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.Type: GrantFiled: November 2, 2015Date of Patent: October 24, 2017Assignee: Nanocarrier Co., Ltd.Inventors: Atsushi Ishii, Yasuki Kato
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Patent number: 9757344Abstract: A coated fine particle comprisisng: (i) a complex of a drug and a cationic lipid, wherein (a) the drug is a nucleic acid and the complex is obtained by mixing the drug and the cationic lipid in water, wherein the complex has a diameter of 10 nm to 1,000 nm, and (ii) a lipid layer formed of lipid(s), wherein the lipid(s) is selected from phospholipid, glyceroglycolipid, sphingoglycolipid, cholesterol and synthetic lipid, wherein the complex is coated with the lipid layer.Type: GrantFiled: February 1, 2010Date of Patent: September 12, 2017Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Yasuki Kato, Masahiro Yamauchi, Hiroko Kusano, Takeshi Iwata, Takaaki Uochi, Shiro Akinaga
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Patent number: 9561284Abstract: A pharmaceutical composition includes a block copolymer having a hydrophilic segment, a hydrophobic segment, and a boronic acid compound bound to a side chain of the hydrophobic segment via a linker moiety that includes a heterocyclic structure. The heterocyclic structure contains a cyclic skeleton that includes a boron atom of the boronic acid compound, one or two atom(s) X bound to the boron atom and selected from an oxygen atom and a nitrogen atom, and one or two carbon atom(s) (respectively) bound to the atom(s) X. The block copolymer further includes at least one organic group bound to the carbon atom(s). The organic group(s) contain(s) an aromatic group or cyclic alkyl group that sterically protects a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atom(s) X.Type: GrantFiled: April 2, 2012Date of Patent: February 7, 2017Assignee: NANOCARRIER CO., LTD.Inventors: Hiroyuki Saito, Katsutoshi Kobayashi, Ryosuke Tanaka, Mitsunori Harada, Yasuki Kato
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Publication number: 20160333113Abstract: Monoclonal antibodies against human and mouse tissue factor, and fragments thereof, are disclosed, as well as pharmaceutical compositions and compositions for drug delivery containing the same. Therapeutic methods using the same are also disclosed.Type: ApplicationFiled: February 3, 2015Publication date: November 17, 2016Applicants: NATIONAL CANCER CENTER, The University of Tokyo, RIKEN, NanoCarrier Co., Ltd.Inventors: Yasuhiro MATSUMURA, Masahiro YASUNAGA, Yoshikatsu KOGA, Yoshiyuki YAMAMOTO, Ryuta SATO, Ryo TSUMURA, Kazunori KATAOKA, Nobuhiro NISHIYAMA, Yutaka MIURA, Shino MANABE, Yasuki KATO
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Patent number: 9415059Abstract: The present invention provides a particulate composition containing: block copolymer units being arranged radially with hydrophobic polymer-chain segments radially inside and hydrophilic polymer-chain segments radially outside; and a charged lipid which carries a charge opposite to the charge of a drug to be encapsulated, the charged lipid being attracted to the hydrophobic polymer-chain segment. In this particulate composition, the drug is retained within the particle via electrostatic binding with the charged lipid, whereby the outer surface of the particle is prevented from being charged to attract a substance which has a charge opposite to that of the charged lipid.Type: GrantFiled: August 31, 2010Date of Patent: August 16, 2016Assignee: Nanocarrier Co., Ltd.Inventors: Yasuki Kato, Atsushi Ishii
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Publication number: 20160114058Abstract: A polymer micelle pharmaceutical composition is provided and includes: a block copolymer unit ? having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; and a block copolymer unit ? having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment, wherein: the block copolymer unit ? and the block copolymer unit ? are radially arranged in the state in which the hydrophilic polymer chain segments are directed outward and the hydrophobic polymer chain segments are directed inward; and the hydrophobic polymer chain segment of the block copolymer unit ? is constituted of repeating units having side chains, at least one of the side chains having a hydrophilic group.Type: ApplicationFiled: May 16, 2014Publication date: April 28, 2016Inventors: Yasuki KATO, Mitsunori HARADA, Ryosuke TANAKA
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Patent number: 9278075Abstract: A composition of matter for use in encapsulating a drug is expressed by formula (1) or formula (2): wherein R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted, linear or branched alkyl group having 1 to 12 carbon atoms; A is a hydrophilic polymer chain; L1 and L3 are each a linking group; B is a cation-containing group; R3 is a side chain of an amino acid; z is an integer of 5 to 500; x is an integer of 40% or more of z; y is 0 or a positive integer; z-x-y is 0 or a positive integer; p is an integer of 1 to 10; and q is an integer of 1 to 10.Type: GrantFiled: January 16, 2012Date of Patent: March 8, 2016Assignees: NANOCARRIER CO., LTD., THE UNIVERSITY OF TOKYOInventors: Kazunori Kataoka, Ronald James Christie, Nobuhiro Nishiyama, Kanjiro Miyata, Shigeto Fukushima, Yu Matsumoto, Takahiro Nomoto, Yasuki Kato
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Publication number: 20160058703Abstract: The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.Type: ApplicationFiled: November 2, 2015Publication date: March 3, 2016Inventors: Atsushi Ishii, Yasuki Kato
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Patent number: 9198860Abstract: The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.Type: GrantFiled: February 14, 2011Date of Patent: December 1, 2015Assignee: NANOCARRIER CO., LTD.Inventors: Atsushi Ishii, Yasuki Kato
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Publication number: 20150265545Abstract: A method for coating fine particles with lipid membrane, characterized in that, the rate of a polar organic solvent in an aqueous solution containing the polar organic solvent where the fine particles are dispersed and lipid is dissolved, is decreased.Type: ApplicationFiled: April 10, 2015Publication date: September 24, 2015Inventors: Yasuki KATO, Masahiro YAMAUCHI, Hiroko KUSANO, Takeshi IWATA, Takaaki UOCHI, Shiro AKINAGA