Patents by Inventor Yasunari Fujiwara

Yasunari Fujiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same
    Patent number: 8324245
    Abstract: An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X?CH or N; Z?O or S; L=O or S; M=CR10R11, wherein R10 and R11?H, alkyl, or alkoxy, NR12 wherein R12?H or alkyl; R1, R2, and R3?H or optionally substituted alkoxy; R4?H; R5-8?H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19?H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: December 4, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yasunari Fujiwara, Terufumi Senga, Tsuyoshi Nishitoba, Tatsushi Osawa, Atsushi Miwa, Kazuhide Nakamura
  • QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME
    Publication number: 20110105747
    Abstract: An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 5, 2011
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Yasunari FUJIWARA, Terufumi Senga, Tsuyoshi Nishitoba, Tatsushi Osawa, Atsushi Niwa, Kazuhide Nakamura
  • Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors
    Patent number: 7495104
    Abstract: An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(?O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: February 24, 2009
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Atsushi Miwa, Tetsuya Yoshino, Tatsushi Osawa, Teruyuki Sakai, Toshiyuki Shimizu, Yasunari Fujiwara
  • QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME
    Publication number: 20080312221
    Abstract: An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
    Type: Application
    Filed: July 17, 2008
    Publication date: December 18, 2008
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Yasunari Fujiwara, Terufumi Senga, Tsuyoshi Nishitoba, Tatsushi Osawa, Atsushi Miwa, Kazuhide Nakamura
  • Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same
    Patent number: 7425564
    Abstract: An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: September 16, 2008
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Yasunari Fujiwara, Terufumi Senga, Tsuyoshi Nishitoba, Tatsushi Osawa, Atsushi Miwa, Kazuhide Nakamura
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Patent number: 7211587
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: May 1, 2007
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
  • Quinoline derivatives and quinazoline derivatives
    Publication number: 20070027318
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
    Type: Application
    Filed: September 26, 2006
    Publication date: February 1, 2007
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives
    Patent number: 7169789
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: January 30, 2007
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors
    Publication number: 20050049264
    Abstract: An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(?O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.
    Type: Application
    Filed: October 17, 2002
    Publication date: March 3, 2005
    Applicant: Kirin Beer Kabushiki Kaisha
    Inventors: Atsushi Miwa, Tetsuya Yoshino, Tatsushi Osawa, Teruyuki Sakai, Toshiyuki Shimizu, Yasunari Fujiwara
  • Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus proliferator receptor and medicinal composition containing the same
    Publication number: 20040242603
    Abstract: An objective of the present invention is to provide compounds having potent antitumor activity.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 2, 2004
    Inventors: Yasunari Fujiwara, Terufumi Senga, Tsuyoshi Nishitoba, Tatsushi Osawa, Kazuhide Nakamura
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Patent number: 6821987
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: November 23, 2004
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Publication number: 20040229876
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity.
    Type: Application
    Filed: June 7, 2004
    Publication date: November 18, 2004
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
  • Quinoline derivatives and quinazoline derivatives
    Publication number: 20040209905
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis.
    Type: Application
    Filed: May 10, 2004
    Publication date: October 21, 2004
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives
    Patent number: 6797823
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: September 28, 2004
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Publication number: 20030087907
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity.
    Type: Application
    Filed: April 26, 2002
    Publication date: May 8, 2003
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa