Patents by Inventor Yasunari Michinaka
Yasunari Michinaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11590106Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.Type: GrantFiled: September 25, 2019Date of Patent: February 28, 2023Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
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Publication number: 20230034383Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 ?g/cm2 in terms of free form.Type: ApplicationFiled: July 21, 2021Publication date: February 2, 2023Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yuka TAKAGI, Kazuya ISHIDA, Ryoma TAMURA, Takao KUROKAWA, Yasunari MICHINAKA
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Publication number: 20220273603Abstract: A method for treating hyperhidrosis is disclosed. The method comprises administering a liquid topical preparation to a patient in need thereof. The liquid topical preparation comprises water and oxybutynin or a pharmaceutically acceptable salt thereof. The oxybutynin or pharmaceutically acceptable salt thereof is present in a range of, for example, from 10 mass % to 20 mass % based on a total mass of the liquid topical preparation.Type: ApplicationFiled: February 28, 2022Publication date: September 1, 2022Inventors: Kana IMAMURA, Naoko FUJITA, Yasunari MICHINAKA
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Patent number: 11364207Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.Type: GrantFiled: February 19, 2018Date of Patent: June 21, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hideaki Ohashi, Takito Shima, Kenji Ishigaki, Yasunari Michinaka
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Publication number: 20210393587Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.Type: ApplicationFiled: September 25, 2019Publication date: December 23, 2021Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
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Publication number: 20210251913Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.Type: ApplicationFiled: April 29, 2021Publication date: August 19, 2021Inventors: Ryo TANAKA, Hideaki OHASHI, Naruhide MIYOSHI, Takito SHIMA, Naoko FUJITA, Yasunari MICHINAKA
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Publication number: 20210228496Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent comprising free asenapine in a range of 2 to 5% by mass, isopropyl palmitate in a range of 5 to 12% by mass, styrene-isoprene-styrene block copolymer in a range of 10 to 20% by mass, polyisobutylene in a range of 3 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 50 to 70% by mass, and liquid paraffin in a range of 5 to 12% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch having an amount of the adhesive agent layer after drying in a range of 100 to 400 g/m2.Type: ApplicationFiled: January 24, 2020Publication date: July 29, 2021Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yuka TAKAGI, Kazuya ISHIDA, Takao KUROKAWA, Yasunari MICHINAKA
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Patent number: 11020356Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.Type: GrantFiled: December 26, 2017Date of Patent: June 1, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Ryo Tanaka, Hideaki Ohashi, Naruhide Miyoshi, Takito Shima, Naoko Fujita, Yasunari Michinaka
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Patent number: 10716763Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.Type: GrantFiled: April 15, 2016Date of Patent: July 21, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naoyuki Uchida, Yasunari Michinaka
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Publication number: 20200121611Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.Type: ApplicationFiled: February 19, 2018Publication date: April 23, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hideaki OHASHI, Takito SHIMA, Kenji ISHIGAKI, Yasunari MICHINAKA
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Patent number: 10525132Abstract: The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.Type: GrantFiled: April 27, 2016Date of Patent: January 7, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kana Imamura, Tomohiro Shinoda, Shingo Somekawa, Yasunari Michinaka
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Publication number: 20190350874Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.Type: ApplicationFiled: December 26, 2017Publication date: November 21, 2019Inventors: Ryo TANAKA, Hideaki OHASHI, Naruhide MIYOSHI, Takito SHIMA, Naoko FUJITA, Yasunari MICHINAKA
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Patent number: 10307381Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.Type: GrantFiled: October 13, 2015Date of Patent: June 4, 2019Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Junji Noguchi, Eisuke Hatanaka, Hisakazu Kurita, Ryusuke Fudoji, Yasunari Michinaka
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Publication number: 20190046493Abstract: The present invention provides a liquid topical preparation having low “stickiness” even when it contains a high concentration of an anticholinergic drug. The liquid topical preparation comprises water, an anticholinergic drug and dicarboxylic acid ester, and the content of the anticholinergic drug ranges from 10 mass % to 20 mass % based on the total mass of the liquid topical preparation.Type: ApplicationFiled: October 26, 2016Publication date: February 14, 2019Inventors: Kana IMAMURA, Naoko FUJITA, Yasunari MICHINAKA
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Publication number: 20180140704Abstract: The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.Type: ApplicationFiled: April 27, 2016Publication date: May 24, 2018Inventors: Kana IMAMURA, Tomohiro SHINODA, Shingo SOMEKAWA, Yasunari MICHINAKA
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Publication number: 20180055783Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.Type: ApplicationFiled: April 15, 2016Publication date: March 1, 2018Inventors: Naoyuki UCHIDA, Yasunari MICHINAKA
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Patent number: 9789188Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one drug selected from the group consisting of emedastine and pharmaceutically acceptable salts thereof, at least one adhesive agent selected from the group consisting of rubber-based adhesive agents and silicone-based adhesive agents, and an alkali metal fumarate as a cohesive force-improving agent for the adhesive agent layer.Type: GrantFiled: October 8, 2013Date of Patent: October 17, 2017Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takuya Umemoto, Yuka Takagi, Yasunari Michinaka
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Publication number: 20170224630Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.Type: ApplicationFiled: October 13, 2015Publication date: August 10, 2017Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Junji NOGUCHI, Eisuke HATANAKA, Hisakazu KURITA, Ryusuke FUDOJI, Yasunari MICHINAKA
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Publication number: 20160374956Abstract: A multilayer-type patch comprising: a support layer; a drug reservoir layer; and an adhesive layer, wherein the drug reservoir layer comprises at least one drug selected from the group consisting of rivastigmine and pharmaceutically acceptable salts thereof, and a hydroxy group-containing acrylic-based polymer (A), the adhesive layer comprises at least one acrylic-based polymer (B) selected from the group consisting of carboxy group-containing alkyl (meth)acrylate copolymer and acrylic acid homopolymer, and a rubber-based adhesive base agent, a content of the drug in the drug reservoir layer in terms of rivastigmine in free form is 15 to 45% by mass relative to a total mass of the drug reservoir layer, and a total content of the acrylic-based polymer (B) in the adhesive layer is 7 to 18% by mass relative to a total mass of the adhesive layer.Type: ApplicationFiled: December 10, 2014Publication date: December 29, 2016Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Tomohiro SHINODA, Yasunari MICHINAKA
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Publication number: 20160354322Abstract: Provided is an emedastine-containing tape preparation comprising a support film, and a pressure-sensitive adhesive layer laminated on the support film, wherein the pressure-sensitive adhesive layer comprises emedastine, a fumarate salt of an organic amine, and a pressure-sensitive adhesive.Type: ApplicationFiled: January 28, 2015Publication date: December 8, 2016Inventors: Yasunari MICHINAKA, Tomohiro SHINODA, Kana IMAMURA