Abstract: Disclosed are layered structures that include a polymeric layer and a varnish layer in contact with the polymeric layer, wires including the layered structures, and methods of making the layered structures. The polymeric layer includes a poly(ether ether ketone)(PEEK) and a poly(aryl ether sulfone) (PAES) and surprisingly exhibits markedly improved adhesion to the varnish layer without significant reduction in crystallization temperature of the polymeric layer.

Abstract: A detection/determination kit with which a substance to be detected or the amount thereof can be rapidly, inexpensively, and easily detected or determined; and a detection/determination method. The kit, which is for detecting a substance to be detected (50) contained in a specimen, comprises: a first compound (10) comprising a first substance including a stimulus-responsive polymer (11) and, bonded to the first substance, a first antibody (13) against the substance (50); and a second compound (20) comprising a second substance (21) which is hydrophilic and, bonded thereto, a second antibody (23) against the substance (50). The first antibody (13) and second antibody (23) can simultaneously combine with the substance (50) at different sites in the substance (50).

Abstract: A detection/determination kit with which a substance to be detected or the amount thereof can be rapidly, inexpensively, and easily detected or determined; and a detection/determination method. The kit, which is for detecting a substance to be detected (50) contained in a specimen, comprises: a first compound (10) comprising a first substance including a stimulus-responsive polymer (11) and, bonded to the first substance, a first antibody (13) against the substance (50); and a second compound (20) comprising a second substance (21) which is hydrophilic and, bonded thereto, a second antibody (23) against the substance (50). The first antibody (13) and second antibody (23) can simultaneously combine with the substance (50) at different sites in the substance (50).

Abstract: Acylaminoquinazoline derivatives of formula ##STR1## (in which: R.sup.1 represents a lower alkoxy group, a substituted or unsubstituted lower alkyl group, a cycloalkyl group, a lower alkenyl group, a vinyl group having an optionally substituted phenyl or furyl substituent, an optionally substituted phenyl group, a furyl group, an oxazolyl group, a methylthiooxadiazolyl group or a tetrahydrofuryl group;R.sup.2 represents a hydrogen atom or a lower alkyl group;R.sup.3 represents a lower alkyl group or an optionally substituted phenyl group;R.sup.4 represents a hydrogen atom or an acyloxy-substituted phenyl group;X represents a methylene group or a sulphur atom; andn is 2 or 3)and pharmaceutically acceptable acid addition salts thereof are valuable antihypertensive agents and inhibit the activity of the angiotension I-converting enzyme.

Abstract: Novel piperazinylquinazoline and homopiperazinylquinazoline compounds which have useful antihypertensive activity and their use including pharmaceutical compositions containing said derivatives as the active antihypertensive component thereof. Said compounds have the following formula. ##STR1## wherein m is 2 or 3 and R is as defined in the specification.

Abstract: Benzothiazocine and benzothiazonine derivatives of formula (I): ##STR1## in which: R.sup.1, R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom or an alkyl group;X.sup.1 and X.sup.2 are the same or different and each represents a hydrogen atom, an alkyl group, an alkoxy group, an alkanesulphinyl group, an alkanesulphonyl group, a halogen atom, a trifluoromethyl group, a nitro group or a cyano group;n is 1 or 2; andm is 0 or 1 (excluding those compounds wherein:R.sup.1, R.sup.2, R.sup.3, X.sup.1 and X.sup.2 all represent hydrogen atoms;n is 1 and m is 0; and wherein:R.sup.1 and R.sup.2 both represent hydrogen atoms;R.sup.3 represents a hydrogen atom or a methyl group;X.sup.1 represents a chlorine atom at the 9-position;X.sup.2 represents a hydrogen atom;n is 1; andm is 0)and acid addition salts thereof are novel compounds which have been found to suppress gastric secretions and are thus useful in the treatment and prevention of gastric ulcers.

Abstract: Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R.sup.2 represents an alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group having from 5 to 8 carbon atoms, a phenyl group optionally substituted with one or more halogen atoms or a phenylalkyl group having the formula ##STR2## IN WHICH R.sup.3 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R.sup.4 represents halogen atom, an alkyl group having from 1 to 4 carbon atoms or an alkoxy group having from 1 to 4 carbon atoms, m represents an integer from 0 to 2 and n represents an integer from 0 to 3, and pharmacologically acceptable salts thereof. The compounds are useful as vasodilating or hypotensive agents and may be prepared by reacting triazolopyrimidine derivatives having the formula ##STR3## wherein X.sup.1 and X.sup.2 may be the same or different and each represents a halogen atom and R.sup.

Abstract: 3-[2-(4-PHENYL-1-PIPERAZINYL)ETHYL]-4H-pyrido[1,2-a]pyrimidin-4-one derivatives have central nervous depressant and hypotensive activities and are useful as major tranquillizers.The compounds can be prepared by (a) reacting 2-methyl-3-halogeno (or arylsulfonyloxy or alkylsulfonyloxy)ethyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative with 1-phenylpiperazine derivative or (b) reacting an aminopyridine with 2-[2-(4-phenyl-1-piperazinyl)ethyl]-acetoacetic acid ester.