Patents by Inventor Yasunori Tawaragi

Yasunori Tawaragi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human CNP gene and precursor protein
    Patent number: 6034231
    Abstract: The gene of a human CNP (human C-type natriuretic peptide), as well as the hCNP precursor protein that is encoded by said gene. The hCNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Ala Glu Glu Leu - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - Met Ser Gly Leu Gly Cys.The hCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: March 7, 2000
    Assignee: Suntory Limited
    Inventors: Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi, Hisayuki Matsuo, Kenji Kanagawa, Naoto Minamino
  • Porcine CNP gene and precursor protein
    Patent number: 6020168
    Abstract: The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is represented by the following amino acid sequence:Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly SerThese derivatives are novel and have natriuretic and hypotensive activities.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: February 1, 2000
    Assignees: Suntory Limited, Hisayuki Matsuo
    Inventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi
  • Peptide and gene coding for same
    Patent number: 5118615
    Abstract: Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA fragment, microorganisms transformed with the plasmid, and a process for production of the peptide using the transformant.Also disclosed is a new peptide consisting of 126 amino acids occurring in human atrium cordis and a precursor thereof. The peptide has notable diuretic action and hypotensive or antihypertensive actions.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: June 2, 1992
    Assignee: Suntory Limited
    Inventors: Hisayuki Matsuo, Kenji Kangawa, Yujiro Hayashi, Shinzo Oikawa, Takehiro Oshima, Shoji Tanaka, Hiroshi Nakazato, Yasunori Tawaragi