Patents by Inventor Yasuo Isomura
Yasuo Isomura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6174896Abstract: Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same. The compound has an antagonistic effect on muscarinic M3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.Type: GrantFiled: May 14, 1999Date of Patent: January 16, 2001Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Makoto Takeuchi, Ryo Naito, Masahiko Hayakawa, Yoshinori Okamoto, Yasuhiro Yonetoku, Ken Ikeda, Yasuo Isomura
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Patent number: 6017927Abstract: Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same. ##STR1## The compound has an antagonistic effect on muscarinic M.sub.3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.Type: GrantFiled: August 28, 1997Date of Patent: January 25, 2000Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Makoto Takeuchi, Ryo Naito, Masahiko Hayakawa, Yoshinori Okamoto, Yasuhiro Yonetoku, Ken Ikeda, Yasuo Isomura
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Patent number: 5981559Abstract: An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and being useful in preventing or treating allergic diseases, ischemic heart diseases or ischemic brain diseases, and a medicinal composition containing the same as the active ingredient, wherein R.sup.1 and R.sup.2 may be the same or different and represent each hydrogen, cycloalkyl, etc., or R.sup.1 and R.sup.2 together with (a) may form a fused ring (b) or (c) which may be substituted by optionally substituted lower alkyl, amino, etc.; R.sup.3, R.sup.6, R.sup.7, R.sup.8 may be the same or different and represent each hydrogen, amino, etc.; R.sup.4 represents cyano, tetrazolyl, --COOR.sup.9, etc.; R.sup.5 represents hydrogen or lower alkyl; D represents optionally substituted lower alkylene; X and Z may be the same or different and represent each oxygen or sulfur; Y represents --N.dbd. or --CH.dbd.Type: GrantFiled: August 15, 1997Date of Patent: November 9, 1999Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Noriko Nagaoka, Masaki Yokota, Hiroaki Akane, Yasuhito Arakida, Yasuo Isomura
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Patent number: 5817670Abstract: 1,8-Naphthyridine derivatives represented by the following general formula (I), salts thereof, hydrates thereof and solvates thereof. ##STR1## They have an activity to inhibit type IV phosphodiesterase and are useful as agents for the prevention and treatment of respiratory diseases, inflammatory diseases accompanying organ transplantation, systemic or local arthropathy, proliferative diseases, micturition-related diseases and diseases in which tumor necrosis factor (TNF) and other cytokine (IL-1, IL-6 or the like) are concerned.Type: GrantFiled: January 30, 1997Date of Patent: October 6, 1998Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kazuhisa Takayama, Masahiro Iwata, Yoshinori Okamoto, Motonori Aoki, Akira Niwa, Yasuo Isomura
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Patent number: 5674886Abstract: A triazolylated tertiary amine compound represented by general formula (I) or a salt thereof, having an aromatase inhibitory activity and being useful for preventing and treating breast cancer, mastopathy, endometriosis, prostatomergaly, etc., wherein A represents a single bond, lower alkylene or carbonyl; B represents lower alkyl, aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; D represents aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; and E represents 4H-1,2,4-triazolyl, 1H-1,2,4-triazolyl or 1H-1,2,3-triazolyl.Type: GrantFiled: February 24, 1994Date of Patent: October 7, 1997Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Minoru Okada, Eiji Kawaminami, Toru Yoden, Masafumi Kudou, Yasuo Isomura
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Patent number: 5616715Abstract: A process is provided for producing diastereoisomer A or a pharmaceutically acceptable acid addition salt of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester which comprises subjecting a mixture of diastereoisomers A and B of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester to column chromatography using silica gel as a carrier and a mixture of ethyl acetate and acetic acid as an eluant, and then separating the acetate of diastereoisomer A from the eluate, or treating the acetate with a base, or further treating the resulting diastereoisomer A with a pharmaceutically acceptable acid.Type: GrantFiled: June 19, 1995Date of Patent: April 1, 1997Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kazuharu Tamazawa, Tadao Kojima, Hideki Arima, Yukiyasu Murakami, Yasuo Isomura, Minoru Okada, Toichi Takenaka, Kiyoshi Takanobu
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Patent number: 5538976Abstract: A substituted tertiary amino compound represented by general formula (I) or a pharmaceutically acceptable salt thereof. They have an aromatase inhibiting activity and are useful as a prophylactic and/or therapeutic agent for breast cancer, mastopathy, endometriosis, prostatic-hypertrophy, and so forth.Type: GrantFiled: October 26, 1994Date of Patent: July 23, 1996Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Minoru Okada, Toru Yoden, Eiji Kawaminami, Yoshiaki Shimada, Masafumi Kudou, Yasuo Isomura
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Patent number: 5480875Abstract: Crystal D or E of 1-hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane -1,1-bis(phosphonic acid) monohydrate having specified lattice spacing and relative intensity in the powder X-ray diffraction spectrum obtained by using Cu-K.alpha. radiation and a dehydration peak temperature of 135.degree. to 149.degree. C. or 160.degree. to 170.degree. C. according to TG-DSC thermogravimetric analysis; and to a solid pharmaceutical preparation containing the same. The crystals are useful for producing a stable solid pharmaceutical preparation of the above compound which has an excellent drug efficacy for diseases wherein increased bone resorption participates, such as osteoporosis.Type: GrantFiled: December 21, 1994Date of Patent: January 2, 1996Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Makoto Takeuchi, Mamoru Hamada, Yoshisaburo Kaneko, Noriya Yamamoto
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Patent number: 5473100Type: GrantFiled: March 24, 1995Date of Patent: December 5, 1995Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Seijiro Akamatsu, Toru Yoden, Masafumi Kudou, Akira Suga
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Patent number: 5463064Abstract: A dextro-rotatory optical isomer of diastereoisomer A of (.+-.)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester is provided having the formula ##STR1## and wherein the melting point of the hydrochloride of the dextro-rotatory optical isomer is 223.degree. to 230.degree. C. (decomp.), or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: May 5, 1994Date of Patent: October 31, 1995Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kazuharu Tamazawa, Tadao Kojima, Hideki Arima, Yukiyasu Murakami, Yasuo Isomura, Minoru Okada, Kiyoshi Takanobu, Toichi Takenaka
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Patent number: 5442110Type: GrantFiled: April 20, 1994Date of Patent: August 15, 1995Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Seijiro Akamatsu, Toru Yoden, Masafumi Kudou, Akira Suga
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Patent number: 5364872Abstract: The diastereoisomer A of a dihydropyridine-3,5-dicarboxylic acid ester derivative is provided as well as its pharmaceutically acceptable acid addition salts. The invention further discloses a process for producing the compounds and their use as medicaments in imparting vasodilating activity.Type: GrantFiled: January 23, 1992Date of Patent: November 15, 1994Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kazuharu Tamazawa, Tadao Kojima, Hideki Arima, Yukiyasu Murakami, Yasuo Isomura, Minoru Okada, Toichi Takenaka, Kiyoshi Takanobu
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Patent number: 5041428Abstract: (Cycloalkylamino)methylenebis(phosphonic acid) represented by the general formula: ##STR1## in which, R, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent a hydrogen atom or a lower alkyl group, and n represents an integer from 3 to 10, a lower alkyl ester thereof or a pharmaceutically acceptable salt thereof; and a bone-resorption inhibitor and an anti-arthritis containing the same.Type: GrantFiled: July 10, 1990Date of Patent: August 20, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Makoto Takeuchi, Shuichi Sakamoto, Tetsushi Abe
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Patent number: 5039669Abstract: A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): ##STR1## in which .circle.Het means one of the following (A) and (B): ##STR2## wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, ##STR3## wherein R.sup.6 and R.sup.7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group,R.sup.1 represents a hydrogen atom or a hydroxyl group,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different, each represents a hydrogen atom or a lower alkyl group,"n" is 0 or 1,provided that "n" is 1 when the ring .circle.Het means (A), and "R.sup.1 " is a hydroxyl group when the ring .dotthalfcircle.Het means (B), or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient.Type: GrantFiled: August 10, 1990Date of Patent: August 13, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Makoto Takeuchi, Tetshshi Abe
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Patent number: 5013725Abstract: Substituted aminomethylenebis(phosphonic acid) derivatives represented by the general formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be the same or different, each represents a hydrogen atom or a lower alkyl group; "m" is zero or represents an integer from 1 to 4; and a ring "A" represents a cycloalkenyl group having 5 to 8 carbon atoms, a bicycloheptyl group, a bicycloheptenyl group or a saturated heterocyclic group having 4 to 7 carbon atoms and containing an oxygen atom, a sulfur atom, a sulfinyl group (--SO--) or a sulfonyl group (--SO.sub.2 --), or pharmaceutically acceptable salts thereof.Type: GrantFiled: March 16, 1990Date of Patent: May 7, 1991Inventors: Yasuo Isomura, Makoto Takeuchi, Shuichi Sakamoto, Tetsushi Abe
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Patent number: 4990503Abstract: A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): ##STR1## in which, .circle.Het means one of following (A) and (B): ##STR2## wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, ##STR3## wherein R.sup.6 and R.sup.7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group,R.sup.1 represents a hydrogen atom or a hydroxyl group,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different, each represents a hydrogen atom or a lower alkyl group,"n" is 0 or 1,provided that "n" is 1 when the ring .circle.Het means (A), and "R.sup.1 " is a hydroxyl group when the ring .circle.Het means (B),or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient.Type: GrantFiled: August 7, 1989Date of Patent: February 5, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Makoto Takeuchi, Tetsushi Abe
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Patent number: 4973576Abstract: "Novel bisphosphonic acid derivatives, and a bone resorption-inhibitor and an anti-arthritis containing a bisphosphonic acid derivative represented by the formula (I): ##STR1## wherein R.sup.2 represents a hydrogen atom, an alkyl group, etc.,R.sup.2 represents a hydrogen atom or a lower alkanoyl group,R.sup.3, R.sup.4, R.sup.5 and R.sup.6 may be the same or different, each represents a hydrogen atom or lower alkyl group.Type: GrantFiled: March 9, 1988Date of Patent: November 27, 1990Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Shuichi Sakamoto, Makoto Takeuchi, Yasuo Isomura, Kunihiro Niigata, Tetsushi Abe, Kousei Kawamuki, Masafumi Kudou
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Patent number: 4970335Abstract: (Cycloalkylamino)methylenebis(phosphonic acid) represented by the general formula: ##STR1## in which, R, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent a hydrogen atom or a lower alkyl group, and n represents an integer from 3 to 10, a lower alkyl ester thereof or a pharmaceutically acceptable salt thereof; and a bone-resorption inhibitor and an anti-arthritis containing the same.Type: GrantFiled: January 23, 1989Date of Patent: November 13, 1990Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Makoto Takeuchi, Shuichi Sakamoto, Tetsushi Abe
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Patent number: 4933472Abstract: Substituted aminomethylenebis(phosphonic acid) derivatives represented by the general formula: ##STR1## in which R.sup.1, R.sup.2 R.sup.3 and R.sup.4 may be the same or different, each represents a hydrogen atom or a lower alkyl group; "m" is zero or represents an integer from 1 to 4; and a ring "A" represents a cycloalkenyl group having 5 to 8 carbon atoms, a bicycloheptyl group, a bicycloheptenyl group or a saturated heterocyclic group having 4 to 7 carbon atoms and containing an oxygen atom, a sulfur atom, a sulfinyl group (--SO--) or a sulfonyl group (--SO.sub.2 --),or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 5, 1989Date of Patent: June 12, 1990Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yasuo Isomura, Makoto Takeuchi, Shuichi Sakamoto, Tetsushi Abe
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Patent number: 4727082Abstract: A dihydropyridine compound of the following general formula (I) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represents a C.sub.1 to C.sub.10 alkyl group, a lower alkyl group which is interrupted by oxygen atom(s), or a lower alkyl group substituted by C.sub.3 to C.sub.6 alicyclic group(s); R.sup.3 and R.sup.4, which are the same or different, each represents a lower alkyl group; R.sup.5 and R.sup.6, which are the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group, or a lower alkylsulfinyl group; R.sup.7 and R.sup.8, which are the same or different, each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkoxy group, or a lower alkanoylamino group, or R.sup.7 may combine with R.sup.8 to form a naphthyl group together with the adjacent phenyl group; A represents a single bond, a vinylene group (--CH.dbd.Type: GrantFiled: September 17, 1986Date of Patent: February 23, 1988Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Takashi Fujikura, Noriki Ito, Yuzo Matsumoto, Yasuo Isomura, Masaharu Asano, Toichi Takenaka