Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.

Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.

Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.

Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.

Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.

Abstract: This application relates to certain novel polycyclic compounds that interact with quadruplex-forming regions of polynucleotides and thereby inhibit translation of genetic information into polypeptides. These compounds can thus provide anticancer and antibacterial and antiviral effects. The invention includes novel compounds and pharmaceutical compositions, and methods of using them to treat cancer and other conditions.

Abstract: A method and device for safety protection of a secondary battery capable of preventing smoking and ignition thereof. A lithium cell 1 as a chargeable and dischargeable secondary battery, a protection circuit 11 for shutting down charging power Pc at the time of overcurrent, overvoltage, etc., and an electric power restriction circuit 20 for limiting the charging power Pc input to the lithium cell 1 are incorporated into a battery pack 10. A battery charger 12, equipped with a stabilized electric source 13 and a charging circuit 14, inputting the charging power Pc to the lithium cell 1, is connected to a previous stage of the battery pack 10. The electric power restriction circuit 20 limits the charging power Pc within a boundary value Pmax of a safety operation region for safely using the lithium cell 1, thereby permitting the lithium cell 1 to operate safely under any conditions.

Abstract: The present invention provides quinolone analogs derivatized with a sulfonic acid, sulfonate or sulfonamide group, which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs quinolone analogs derivatized with a sulfonic acid, sulfonate or sulfonamide group, and methods of using the same.

Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.

Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.

Abstract: A method and device for safety protection of a secondary battery capable of preventing smoking and ignition thereof. A lithium cell 1 as a chargeable and dischargeable secondary battery, a protection circuit 11 for shutting down charging power Pc at the time of overcurrent, overvoltage, etc., and an electric power restriction circuit 20 for limiting the charging power Pc input to the lithium cell 1 are incorporated into a battery pack 10. A battery charger 12, equipped with a stabilized electric source 13 and a charging circuit 14, inputting the charging power Pc to the lithium cell 1, is connected to a previous stage of the battery pack 10. The electric power restriction circuit 20 limits the charging power Pc within a boundary value Pmax of a safety operation region for safely using the lithium cell 1, thereby permitting the lithium cell 1 to operate safely under any conditions.

Abstract: A chargeable and dischargeable lithium cell and the filter unit capable of absorbing flammable materials are housed inside a casing. When an overvoltage is impressed from a battery charger to a battery pack and then internal gases inside the lithium cell are discharged out of an explosion-proof valve, the flammable materials included in internal gases are absorbed by the filter unit to change the internal gases into nonflammable gases. The internal gases purified by passing through the filter unit are exhausted from a gas-vent opening to the outside of the casing. By providing the filter unit inside the casing, the flammable materials discharged out of the lithium cell 1 can be prevented from leaking to the outside of the casing.

Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration (if the compounds of the invention.

Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure where R1–R9, X, Y and Z are defined herein.

Abstract: The present invention relates to a porous resin stamp which can repeatedly seal without supplying ink for a long period of time by beforehand soaking ink therein. The present invention also relates to a cartridge comprising the porous resin stamp and a stamp comprising the cartridge. Colors of the stamp can be intentionally adjusted by adjusting the amount of heating materials combined or the mixing rate of heating materials. Thus, it is possible to precisely check the desired letters, designs, patterns and so on. Furthermore, it is possible to intentionally adjust efficiency rate of heat generation of the heating materials by suitably changing the amount of heating materials. This makes it possible to express any small letters, minute designs and patterns with high reproducibility.

Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure 1

Abstract: The present invention relates to a porous resin stamp which can repeatedly seal without supplying ink for a long period of time by beforehand soaking ink therein. The present invention also relates to a cartridge comprising the porous resin stamp and a stamp comprising the cartridge. Colors of the stamp can be intentionally adjusted by adjusting the amount of heating materials combined or the mixing rate of heating materials. Thus, it is possible to precisely check the desired letters, designs, patterns and so on. Furthermore, it is possible to intentionally adjust efficiency rate of heat generation of the heating materials by suitably changing the amount of heating materials. This makes it possible to express any small letters, minute designs and patterns with high reproducibility.

Abstract: The present invention aims to provide a porous resin stamp, which can repeatedly seal without supplying ink for a long period of time by beforehand soaking ink therein, and a producing method thereof. The present invention is characterized in the producing method of porous resin stamp, wherein an original that can selectively pass light through is put together with a porous resin body combined with at least phathalocyanine pigments as heating material which generate heat by light irradiated from a light source; the light is irradiated from the original side toward the surface of porous resin body; and an ink inexuding portion is formed by melting a surface layer of the porous resin body with heat of the heating material generated by the light passed through the original.