Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: The endoscope has an elongated outer tube 2 and an optical element unit 3 provided inside the outer tube 2, the outer tube 2 has an inner layer 21 configured by a soft resin, a reinforcement layer 22 provided outside the inner layer 21, and an outer layer 23 configured by a soft resin covering the reinforcement layer 22; and the optical element unit 3 has an image transmission portion for image transmission 31, a laser transmission portion 32, and a fiber bundle for illumination 33 to fill the space between an inner surface 21a of the inner layer 21, an outer surface 31a of the image transmission portion 31, and an outer surface 32a of the laser transmission portion 32.

Abstract: An object of the present invention is to provide an implant structure assuring that substances accelerating breeding of bacteria are hard to be induced. The implant structure comprises: an artificial tooth root including an artificial tooth root main body having a distal end portion and a proximal end portion and a thread being formed at least on the distal end portion side and an induction portion for inducing a soft tissue provided on an outer periphery of the proximal end portion of the artificial tooth root main body; and a support base having a covering portion at the proximal end portion side of the support base covering the whole surface of the proximal end portion side of the induction portion, wherein the support base is provided with a step portion along its outer periphery from the covering portion toward a distal end side of the support base.

Abstract: The present invention relates to an inflow cannula for blood circulatory assist devices, having a robust structure and possessing a thrombus anchoring effect. Furthermore, the inflow cannula for blood circulatory assist devices does not deform or exhibit loss of dimensional accuracy during the manufacture process. These features are achieved by a porous structure formed of one or more linear elements or of a porous shaped article.

Abstract: An object of the present invention is to provide an implant structure assuring that substances accelerating breeding of bacteria are hard to be induced. The implant structure comprises: an artificial tooth root including an artificial tooth root main body having a distal end portion and a proximal end portion and a thread being formed at least on the distal end portion side and an induction portion for inducing a soft tissue provided on an outer periphery of the proximal end portion of the artificial tooth root main body; and a support base having a covering portion at the proximal end portion side of the support base covering the whole surface of the proximal end portion side of the induction portion, wherein the support base is provided with a step portion along its outer periphery from the covering portion toward a distal end side of the support base.

Abstract: The present invention relates to an inflow cannula for blood circulatory assist devices, having a robust structure and possessing a thrombus anchoring effect. Furthermore, the inflow cannula for blood circulatory assist devices does not deform or exhibit loss of dimensional accuracy during the manufacture process. These features are achieved by a porous structure formed of one or more linear elements or of a porous shaped article.

Abstract: [Problems] To provide a double needle enabling easy centesis in bones and cortex and easy alignment of an inner needle with an outer needle in an angular direction and capable of transmitting torque when the inner needle and the outer needle are rotated simultaneously. [Means for Solving Problems] This double needle (10) for medical treatment comprises the cylindrical outer needle (11) having an edge part (26) at its tip and the solid inner needle (12) detachably stored in the outer needle. When the outer needle (11) is rotated about its major axis, the rotating diameter of the edge part (26) is larger than the rotating diameter of a body part. Also, the double needle comprises a corotation mechanism (20) for the outer needle (11) and the inner needle (12).

Abstract: A medical material 10 used for an artificial tooth root (FIG. 1b) or an artificial bone (FIG. 1c). The medical material comprises a support 11 composed of titanium web and an outer layer 12 composed of bioabsorbable calcium phosphate compound formed in the periphery thereof.

Abstract: [Problems] To provide a medical material having such a structure that enables even diffusion and distribution in the material of a sufficient amount a substance necessary for a medical treatment. [Means for Solving Problems] A medical material 10 composed of a porous three-dimensional construct 11, which is a rectangular parallelepiped having a porosity of from 20 to 97% and pores 12, 13, 14 and 15 provided in the main body. From this pore 12, a substance such as calcium phosphate or ceramics apatite and/or a physiologically active cell, tissue or protein and a substance suitable for exerting the functions thereof are introduced.

Abstract: Using a bended puncturing needle, a through hole from the greater trochanter of a long tubular bone to the bone marrow cavity is formed, the catheter 61a, 61b is passed into the through hole, a physiological salt solution is injected from one of the catheter 61b, and the physiological salt solution and the bone marrow is stirred by the stirring wire 68, the obtained mixed liquid is aspirated and harvested by another catheter 61a, thereby a large amount of the bone marrow is harvested. A method enabling easy and a large amount harvesting of the bone marrow from long tubular bones such as femurs, in which a multi-lumen catheter can also be used as a catheter.

Abstract: To provide an implant material which exhibits relatively high mechanical binding with an osteoblast and also high strength. [MEANS FOR SOLVING PROBLEMS] A scaffold material (10) capable of inducing a biological hard tissue, which comprises a rod (11) having a trunk portion (21) and bride girders (22), a binding layer (13) formed on the periphery of the rod and a metal fiber layer (14) formed on the periphery of the binding layer, and which further has a reinforcing layer (15) formed on the periphery of the metal fiber layer (14). The binding layer (13) has pores having an average pore size of less than 100 m, and the metal fiber layer (14) has pores having an average pore size of 100 to 400 m.

Abstract: An ultra-miniature in-vivo electrode used for measuring the bioelectrical neural activity etc. in a living body with small cubic volume, slight burden to the living body, and high insulation performance, thereby facilitating long term stable measurements. Structurally the in-vivo electrode comprises conductors 13, 14 made of polymeric material having a through-hole 19 in each center so as to lead a measuring object 18; a intervening member 15 made of non-conductive polymeric material provided in between the conductors so as to insulate the periphery of the conductors; edge members 16, 17 provided in the outer edge of the conductors; a clad body 12 made of cylindrical insulant enclosing the periphery of them; measuring wires 21,22 to lead electricity to outside from each conductor 21, 22; a slit 26 which reaches the through-hole 19 from the outside surface being formed in all of the conductors, the intervening member, the edge members, and the clad body.

Abstract: An ultra-miniature in-vivo electrode used for measuring the bioelectrical neural activity etc. in a living body with small cubic volume, slight burden to the living body, and high insulation performance, thereby facilitating long term stable measurements. Structurally the in-vivo electrode comprises conductors 13, 14 made of polymeric material having a through-hole 19 in each center so as to lead a measuring object 18; a intervening member 15 made of non-conductive polymeric material provided in between the conductors so as to insulate the periphery of the conductors; edge members 16, 17 provided in the outer edge of the conductors; a clad body 12 made of cylindrical insulant enclosing the periphery of them; measuring wires 21,22 to lead electricity to outside from each conductor 21 ,22; a slit 26 which reaches the through-hole 19 from the outside surface being formed in all of the conductors, the intervening member, the edge members, and the clad body.

Abstract: In a method for recording and/or reproducing digital data, such as digital audio signals recorded simultaneously with video signals, dividing sampling data composed of a plurality of bits into higher order bits and lower order bits, constituting error correction coding blocks by only the higher and lower order bits of the sampling data of a plurality of samples respectively, thereby making it possible to easily realize adaptive error checking in the course of the block-by-block error checking in association with, for example, data criticality.A sync word and a block address are affixed to the error correction coding block constituted in that manner. Since one block address is formed using the address data of two or more blocks, a broader address space can be obtained even when the bit number of the address area of each block is few.

Abstract: A control cable having an inner cable, a conduit for slidably guiding the inner cable, a tubular liner in the conduit and an interposition. The conduit has an outer spring coated with a synthetic resin. The outer spring is made by spirally winding a steel wire around the liner with remaining a clearance between an inner surface of the outer spring and an outer surface of the liner. The interposition is set in the clearance in order to keep a suitable clearance and to provide a suitable resistance for a relative motion between the liner and the outer spring so that thermal expansion and contraction of the liner is not hindered and the liner cannot easily slip out of the outer spring.

Abstract: In a high definition television system (HDTV), a video signal is recorded on and reproduced from oblique and successive parallel tracks on a magnetic tape, and an audio signal is recorded on and reproduced from a plurality of parallel tracks extending in a longitudinal direction of the tape. The tape is transported in its longitudinal direction during recording and reproduction. A tape position adjuster adjusts the position of the magnetic tape in its transport direction, and first and second transducing heads located at positions separated by a predetermined distance which may vary slightly because of manufacturing tolerances are employed for respectively reproducing and recording the audio signal. When the tape is edited, a processor connected to the first transducing head processes a reproduced audio signal and supplies it to the second transducing head, which records it accordingly.