Patents by Inventor Yasuo Shikinami

Yasuo Shikinami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5858395
    Abstract: A base polymer for transdermal absorption preparation, which is a solid at ordinary temperatures, which becomes a liquid having a low viscosity near the skin temperature of human, which has heat-sensitive and water-sensitive properties as it has a hydrophilic segment, which is capable of stably storing the drug which conventionally has not been easily formulated into a transdermal absorption preparation, and which is capable of effecting transdermal absorption of the drug at a high releasing ratio and yet in a slow-releasing manner with less skin irritation. The base polymer comprises a heat-sensitive segment polyurethane which is represented by the following general formula:R--A--(U)--C--(U)--B--R'wherein A and B each represents a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof, R and R' each represents a terminal H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7 or C.sub.4 H.sub.9 thereof, and A=B or A.noteq.B, R=R' or R.noteq.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: January 12, 1999
    Assignee: Takiron Co., Ltd.
    Inventor: Yasuo Shikinami
  • Patent number: 5773490
    Abstract: Pressure sensitive adhesives for transdermal absorption formulations comprising a segmented polyurethane, which can control dissolution and a releasing property of drugs of various kinds which are solid at normal temperature; said segment being an alkylene oxide chain which is in a liquid state at a temperature of around normal temperature to around body temperature, and said segment containing a hydrophilic alkylene oxide chain and a hydrophobic alkylene oxide chain, or comprising one or both of them and an alkylene oxide chain in which a hydrophilic moiety and a hydrophobic moiety are present in the mixed manner.
    Type: Grant
    Filed: February 22, 1996
    Date of Patent: June 30, 1998
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Kunihiro Hata
  • Patent number: 5723145
    Abstract: The present invention provides a transdermal absorption preparation whereby a drug, which takes effect with a small amount, and is liable to be decomposed, solid at ordinary temperatures, water-soluble and less absorbable into the skin, can be stored stably for a long period of time and, can be transdermally administered at a high releasing ratio and yet releasing slowly, when applied to the skin. The constitution of the present invention is as follows: a transdermal absorption preparation which comprises a drug-storing layer containing a drug and having a drug-releasing face coated with a drug-releasing controlling membrane, wherein said drug-storing layer comprises as a base a heat-sensitive segmented polyurethane represented by the general formula:R--A--(U)--F--(U)--B--R'wherein A and B each represents a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof, R and R' each represents a terminal H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: March 3, 1998
    Assignees: Takiron Co., Ltd., Ono Pharmaceutical Co., Ltd.
    Inventors: Yasuo Shikinami, Kunihiro Hata, Seiei Sasatani, Masao Sudoh
  • Patent number: 5711960
    Abstract: This invention provides an implant material which has high mechanical strength and durability in three-dimensional directions and a function to synchronize with deformation characteristics of surrounding biological tissues, is capable of being penetrated by biological tissues into its fabric space, and does not cause foreign body reaction or can positively connect with biological tissues, so that it can be implanted in the living body for a prolonged period of time. It uses, as a base material, a biocompatible bulk structure of a three-dimensionally woven or knitted fabric of organic fibers or a composite fabric thereof, and its void ratio in the fabric is preferably set to 20 to 90 vol %. More preferably, the surface of organic fibers which constitute the bulk structure is biologically activated or inactivated.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: January 27, 1998
    Assignee: Takiron Co., Ltd.
    Inventor: Yasuo Shikinami
  • Patent number: 5563191
    Abstract: A phase-separated membrane in which the control of permeation rate and the control of permeation amount of a minute amount of drugs or other chemical substances are easily performed is provided. The phase-separated membrane has a constitution that a crosslinked gelatin phase 1 and an uncrosslinked segmented polyurethane phase 2 are present as a mixture. The segmented polyurethane phase is in a solid state at ordinary temperatures and is molten into a liquid state at 30.degree. to 40.degree. C. which is near the temperature of human skin.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: October 8, 1996
    Assignee: Takiron Co., Ltd.
    Inventor: Yasuo Shikinami
  • Patent number: 5298602
    Abstract: A polymeric piezoelectric material including a polylactic acid molded article having been uniaxially drawn to an extent causing no fibrillation. The piezoelectric material exhibits piezoelectric properties equal to or higher than those of electret type or polypeptide type piezoelectric materials while having high enough mechanical strength to be processed into various articles ranging from films to profiles depending on the end use.
    Type: Grant
    Filed: January 28, 1993
    Date of Patent: March 29, 1994
    Assignee: Takiron Company, Ltd.
    Inventors: Yasuo Shikinami, Kunihiro Hata
  • Patent number: 5227412
    Abstract: Biodegradable and resorbable surgical materials of molded articles of poly(lactic acid) or copolymers of lactic acid and glycolic acid, characterized in that the articles are molecular-orientated, and having a bending strength of 1.6.times.10.sup.33 to 2.5.times.10.sup.3 kg/cm.sup.2, a bending modulus of 5.5.times.10.sup.2 to 24.0.times.10.sup.2 kg/cm.sup.2, a crystallinity, determined by density measurement, of 10 to 60%, and a viscosity average molecular weight measured after melt processing of not less than 200,000, and in that at least 80% of initial strength of the articles is maintained after dipping in a saline at 37.degree. C. for three months.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: July 13, 1993
    Assignees: Biomaterials Universe, Inc., Takiron Co., Ltd.
    Inventors: Suong-Hyu Hyon, Yoshito Ikada, Yasuo Shikinami, Kaoru Tsuta, Hidekazu Boutani
  • Patent number: 5039774
    Abstract: A one-component system polyurethane gel and a coupler for ultrasonic diagnostic probes comprising the same are disclosed. The gel is obtained by reacting a polyol having a room temperature liquid alkylene oxide chain and/or a polyurethane polyol prepolymer having a room temperature liquid alkylene oxide chain with a polyurethane polyisocyanate prepolymer having a room temperature liquid alkylene oxide chain. The gel causes no bleeding or evaporation of a dispersion medium and is therefore excellent in safety to the human body and preservation stability.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: August 13, 1991
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Kaoru Tsuta, Masahiko Taniguchi, Hidekazu Boutani
  • Patent number: 4997656
    Abstract: An adhesive for percutaneous administration having a drug-containing layer composed of a base component mainly comprising a heat-sensitive and water-sensitive amphiphilic polymer and a drug incorporated in the base component. The amphiphilic compound has a characteristic hydrophobicity-hydrophilicity tapered structure, and a variety of liquid or solid or lipophilic (hydrophobic) or hydrophilic drugs of a broad range can stably be dissolved or dispersed therein. The drug in the drug-containing layer remains stable without being released or diffused while the adhesives are stored, and upon application to the skin, the drug is gradually released and diffused into the skin with high availability in a specifically controlled pattern. The present adhesive is especially advantageous for endermic presentation of a slight amount of a substance of high physiological activity which is unstable and is easily decomposed by heat or water.
    Type: Grant
    Filed: May 23, 1989
    Date of Patent: March 5, 1991
    Assignees: Takiron Co., Ltd., Ono Pharmaceutical Co., Ltd.
    Inventors: Yasuo Shikinami, Seiei Sasatani
  • Patent number: 4981689
    Abstract: This invention relates to a repellent material comprising an amide type repelling ingredient, a chlorinated polyethylene and a thermoplastic elastomer, and more particularly to an insect repellent material for preventing insects such as flies, mites, cockroaches and other insects from invading into electronic balances, telephones, computers, facsimiles, automatic vending machines and others in kitchens, foodshops, food storages, foodfirms, or offices, clean rooms, which has an excellent repelling effect to the insects, the repelling effect being controllable for a long period of time in view of using aims.
    Type: Grant
    Filed: June 1, 1990
    Date of Patent: January 1, 1991
    Assignees: Takiron Co., Ltd., Earth Chemical Co., Ltd
    Inventors: Yasuo Shikinami, Kunihiro Hata, Hiroshi Kimura, Kiyoshi Utsumi
  • Patent number: 4966953
    Abstract: A one-component system polyurethane gel and a coupler for ultrasonic diagnostic probes comprising the same are disclosed. The gel is obtained by reacting a polyol having a room temperature liquid alkylene oxide chain and/or a polyurethane polyol prepolymer having a room temperature liquid alkylene oxide chain with a polyurethane polyisocyanate prepolymer having a room temperature liquid alkylene oxide chain. The gel causes no bleeding or evaporation of a dispersion medium and is therefore excellent in safety to the human body and preservation stability.
    Type: Grant
    Filed: May 23, 1989
    Date of Patent: October 30, 1990
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Kaoru Tsuta, Masahiko Taniguchi, Hidekazu Boutani
  • Patent number: 4855077
    Abstract: An ionic conductive polymeric sticking agent comprising: (a) a reaction product of (i) a polyurethanepolyol prepolymer having an alkylene oxide chain and/or a polyol having an alkylene oxide and (ii) a polyurethane polyisocyanate prepolymer having an alkylene oxide chain, and (b) an ionic compound.
    Type: Grant
    Filed: April 20, 1988
    Date of Patent: August 8, 1989
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Kunihiro Hata, Yutaka Ohmura
  • Patent number: 4762899
    Abstract: The present invention provides multiblock hydrophilicity-hydrophobicity tapered amphiphilic segment polyurethanes represented by the following general formula (A): ##STR1## wherein (S) is (a) a polyalkylene oxide segment represented by the following general formula (I):--R.sub.1 --O--R.sub.1 --O).sub.
    Type: Grant
    Filed: May 14, 1987
    Date of Patent: August 9, 1988
    Assignee: Takiron Co., Ltd.
    Inventor: Yasuo Shikinami
  • Patent number: 4362773
    Abstract: A flocked foam having an embossed pattern provided by a high-frequency welder is disclosed. The foam comprises a partially cross-linked foam substrate (10 to 75% gel fraction in boiling toluene for 15 hours) formed from a 1,2-polybutadiene resin or a polymer blend including a 1,2-polybutadiene resin as one component thereof, and modacrylic pile fibers or a mixture thereof with other pile fibers flocked on the surface of the foam substrate.
    Type: Grant
    Filed: June 26, 1980
    Date of Patent: December 7, 1982
    Assignee: Takiron Co., Ltd.
    Inventor: Yasuo Shikinami
  • Patent number: 4144153
    Abstract: A process for producing a photodegradable rubber foamed products of excellent softness, which comprises mixing 1,2-polybutadiene with 0.1 to 3.0% of a photosensitizer and with a thermally decomposable foaming agent, irradiating with ultraviolet ray of a wavelength of 240 to 400 m.mu. for 10 minutes or less to form a cross-linked material having a gel fraction of 30 to 80% (in boiling toluene; 7 hours), and heating to 150 to 230.degree. C. to form a foamed product. In particularly preferred embodiments of this invention, the foaming agent is p,p'-oxybis (benzenesulfonylhydrazide).
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: March 13, 1979
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Ryuichi Kimura, Yoshinobu Yoshikawa, Kosuke Iida, Kunihiro Hata
  • Patent number: 4142956
    Abstract: A process for producing an open cell foam by irradiating a composition comprising (a) a thermoplastic resin polymer blend including 1,2-polybutadiene as one component, (b) a photosensitizing agent and (c) a thermally decomposable foaming agent, with ultraviolet light having a wavelength ranging from about 254 to about 400 m.mu. to thereby cross-link mainly the 1,2-polybutadiene, and subsequently foaming the composition at a temperature higher than the softening point of the 1,2-polybutadiene and that of the thermoplastic resin polymer blended therewith and higher than the decomposition temperature of the foaming agent.
    Type: Grant
    Filed: June 21, 1977
    Date of Patent: March 6, 1979
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Kosuke Iida, Kunihiro Hata, Fumio Kasajima
  • Patent number: 4029840
    Abstract: Synthetic leather comprising cross-linked foamed syndiotactic 1,2-polybutadiene as a main ingredient.
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: June 14, 1977
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Kosuke Iida, Kunihiro Hata, Tetsuya Fujii