Patents by Inventor Yasuo Sugiyama
Yasuo Sugiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6235731Abstract: A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.Type: GrantFiled: October 8, 1998Date of Patent: May 22, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Yumiko Shibouta, Yasuo Sugiyama, Tetsuji Kawamoto, Muneo Takatani
-
Patent number: 6110909Abstract: This invention provides new benzoxazepine compounds represented by the formula: ##STR1## [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R.sub.1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.Type: GrantFiled: March 12, 1998Date of Patent: August 29, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Yasuo Sugiyama, Ryuichi Tozawa
-
Patent number: 5998433Abstract: This invention provides new condensed furan compounds which exhibit excellent 2,3-oxidosqualene cyclase inhibition and high-density lipoprotein-cholesterol elevating activities.This invention also provides a therapeutic and prophylactic agent for hyperlipidemia, hypercholesterolemia and atherosclerosis.Type: GrantFiled: November 14, 1995Date of Patent: December 7, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yasuo Sugiyama, Ryuichi Tozawa, Kazumasa Hamamura
-
Patent number: 5929107Abstract: Novel compound represented by the formula: ##STR1## wherein ring A, ring B and ring C each stands for an optionally substituted benzene ring; X stands for --NR-- wherein R stands for hydrogen atom or an optionally substituted hydrocarbon group, --O-- or --S--; Y stands for --(CH.sub.2)n-- wherein n denotes 1 or 2 or --NH--; and R.sup.a stands for a hydrogen atom or an optionally substituted hydrocarbon group, provided that when ring C is unsubstituted or substituted only at para-position, ring B is substituted at least at ortho-position or a salt thereof which have an excellent acyl-CoA: cholesterol acyltransferase inhibiting action and cholesterol-lowering activity, their production and medicinal use.Type: GrantFiled: November 8, 1995Date of Patent: July 27, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Hideaki Natsugari, Yasuo Sugiyama, Yoshinori Ikeura
-
Patent number: 5885979Abstract: N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.Type: GrantFiled: May 7, 1997Date of Patent: March 23, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Ryuichi Tozawa, Masakuni Kori, Kazuaki Kitano, Yasuo Sugiyama
-
Patent number: 5847368Abstract: An electric heating unit comprises a heat-insulating main body consisting primarily of a heat-insulating material and formed with a groove in a surface thereof, and a heating element provided in the groove and shaped in the form of waves with an amplitude greater than the width of the groove, the heating element having at widthwise opposite sides thereof bent portions extending into the main body from groove-defining opposite side walls thereof and thereby integrally supported by the main body. A bottom-forming member of refractory material made separately from the main body covers the bottom of the groove and is supported by the main body integrally therewith so that the surface of the member toward the opening of the groove is exposed from the main body. The heating element is disposed closer to the groove opening than the bottom-forming member and integrally supported by the main body so as to be in contact with portions of the surface of the member.Type: GrantFiled: June 20, 1996Date of Patent: December 8, 1998Assignee: Koyo Lindberg LimitedInventor: Yasuo Sugiyama
-
Patent number: 5726306Abstract: N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.Type: GrantFiled: November 9, 1994Date of Patent: March 10, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Ryuichi Tozawa, Masakuni Kori, Kazuaki Kitano, Yasuo Sugiyama
-
Patent number: 5698691Abstract: Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula ##STR1## wherein R.sub.1 is hydrogen or an optionally substituted hydrocarbon group; R.sub.2 is hydrogen, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic ring group; X' is a substituent comprising an optionally esterified carboxyl group, an optionally substituted carbamoyl group, an optionally substituted hydroxyl group, an optionally substituted amino group or an optionally substituted heterocyclic radical having a protonizable hydrogen; Ring A is an optionally substituted benzene ring or an optionally substituted aromatic heterocyclic ring; Ring J' is a 7- to 8-membered heterocyclic ring containing at most three ring constituting hetero atoms; D is C or N; the Ring J' optionally having, besides R.sub.1, R.sub.Type: GrantFiled: September 26, 1994Date of Patent: December 16, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Ryuichi Tozawa, Yasuo Sugiyama, Masakuni Kori
-
Patent number: 5677298Abstract: Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula (I) ##STR1## wherein R.sub.1 stands for H or an optionally substituted hydrocarbon group; R.sub.2 and R.sub.3 independently stand for H, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic group; Z stands for a carbon chain containing a double bond or --Z'--C(OH)-- (Z' stands for a bond or a straight-chain or branched alkylene chain); the symbol .........Type: GrantFiled: August 13, 1996Date of Patent: October 14, 1997Assignee: Takeda Chemical IndustriesInventors: Hidefumi Yukimasa, Masakuni Kori, Ryuichi Tozawa, Yasuo Sugiyama
-
Patent number: 5492929Abstract: Novel compound represented by the formula: ##STR1## wherein ring A, ring B and ring C each stands for an optionally substituted benzene ring; X stands for --NR-- wherein R stands for hydrogen atom or an optionally substituted hydrocarbon group, --O-- or --S--; Y stands for --(CH.sub.2)n-- wherein n denotes 1 or 2 or --NH--; and R.sup.a stands for a hydrogen atom or an optionally substituted hydrocarbon group, provided that when ring C is unsubstituted or substituted only at para-position, ring B is substituted at least at ortho-position or a salt thereof which have an excellent acyl-CoA: cholesterol acyltransferase inhibiting action and cholesterol-lowering activity, their production and medicinal use.Type: GrantFiled: December 14, 1993Date of Patent: February 20, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Hideaki Natsugari, Yasuo Sugiyama, Yoshinori Ikeura
-
Patent number: 4682333Abstract: A decoder for decoding a code C which is two-stage encoded by a C.sub.1 code ((N, K, D) Q dimensional code) and a C.sub.2 code ((n, k, d) q dimensional code), which includes: a C.sub.1 decoder including an error correction means for conducting an error correction of the errors below the number [(D-1)/2] to output the decoded word, and a weight generator which generates wj (j=1, 2, . . . , n) when i (i=0 to [(D-1)/2 ]) errors are corrected and an error detection (correction disability) is judged; a C.sub.2 decoder for decoding the C.sub.2 code including a forfeiture error correction means for judging the position j of the wj among the weight vector w in the received word r which is obtained in accordance with the decoded word output from the C.sub.1 decoder, and conducting a forfeiture error decoding. A weighted distance calculating means for calculating the weighted distance .rho..sup.(k) between the decoded word r.sup.(k) and the received word r when a decoded word in each of K=0, 1, . . .Type: GrantFiled: June 24, 1985Date of Patent: July 21, 1987Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Ken Onishi, Yasuo Sugiyama
-
Patent number: 4643939Abstract: An oil absorbing cosmetic tissue consisting of an oil absorbant sheet impregnated with a bactericide, the tissue thus able to remove excess skin oil and at the same time suppress the proliferation of bacteria so as to reduce the adverse effects of bacteria on the skin.Type: GrantFiled: March 4, 1986Date of Patent: February 17, 1987Assignees: Shiseido Company Ltd., Nakamura Bussan Kabushiki KaishaInventors: Yasuo Sugiyama, Osamu Hiraoka, Tamotsu Nakazawa, Kenji Nakamura
-
Patent number: 4590712Abstract: A vertical spindle duplex head for a grinder includes an annular pressure wheel and a receiver wheel arranged to rotate and revolve workpieces between the annular surfaces of the pressure wheel and the receiver wheel and a grindstone for one end portion of the workpieces driven in the opposite directions of rotation of the pressure wheel and receiver wheel and at their different rotational ratios. The workpieces rotate and revolve between these wheels, thereby grinding their end face by means of a grindstone arranged around the external periphery of a rotary carrier.Type: GrantFiled: October 4, 1985Date of Patent: May 27, 1986Assignees: Koyo Seike Company Limited, Koyo Machine Industries CompanyInventors: Yasuo Sugiyama, Masaomi So, Ichiro Hamaguchi, Kenichi Maeda
-
Patent number: 4336612Abstract: A rectangular array of 6.times.150 bits is divided into 50 rectangular arrays of 8.times.3 bits with 2 check bits added, resulting in 50 codes C.sub.2. This encoding is executed 50 times to form a rectangular array of 8.times.150 bits and each of its rows is encoded into a code C.sub.1 of 166 bits with 16 check bits added. This encoding is executed eight times to form a codeword of a generalized product code, which includes 8.times.166 bits and each row following 12 synchronizing bits. Errors are detected in the codes C.sub.1 decoded from the codeword to produce erasure information which is utilized to correct the code C.sub.2. Then, the original array is reproduced.Type: GrantFiled: May 16, 1980Date of Patent: June 22, 1982Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Toru Inoue, Yasuo Sugiyama, Ken Onishi