Abstract: The present invention relates to therapeutic and/or prophylactic agents for ocular inflammatory disease, which comprise an interleukin 6 (IL-6) receptor inhibitor as an active ingredient.

Abstract: The present invention relates to therapeutic and/or prophylactic agents for ocular inflammatory disease, which comprise an interleukin 6 (IL-6) receptor inhibitor as an active ingredient.

Abstract: An object is to provide an artificial vision system ensuring a wide field of view without damaging a retina. In the artificial vision system, a plurality of electrodes (23) are to be implanted so as to stick in an optic papilla of an eye of a patient. A signal for stimulation pulse is generated based on an image captured by an image pick up device (11) to be disposed outside a body of the patient. The electrical stimulation signals outputted from the electrodes (23) based on the signals for stimulation pulse stimulate an optic nerve of the eye, thereby enabling the patient to visually recognize the image from the image pickup device (11).

Abstract: A sight regeneration assisting device for regenerating the sight of a patient comprises a plurality of needlelike electrodes each having a pointed distal end and being to be inserted in an optic papilla of a patient's eye in use; and a signal generator connected with the electrodes through a conductive wire to generate an electric stimulus pulse signal to be outputted from the electrodes, each of the electrodes, excepting a predetermined portion including the distal end, being coated with a coating layer made of resin exhibiting good biocompatibility and insulation, and the coating layer being formed with a turn-back retaining portion for retaining the electrode.

Abstract: The present invention provides a feeder cell for target cell induction, wherein the feeder cell is transduced with an immortalizing gene and a suicide gene; and a production process for a target cell sheet using the feeder cell for target cell induction.

Abstract: A visual restoration aiding device for restoring vision of a patient, comprises: a signal generation unit including a substrate to be placed on an outer side of a choroid of a patient's eye and a plurality of electrodes arranged on the substrate for applying electrical stimulation pulse signals to cells constituting a retina; a photographing unit which photographs an object to be recognized by the patient; and a processing unit which converts image data obtained by the photographing unit to data for electrical stimulation pulse signal and transmits the converted data to the signal generation unit: wherein, based on the data for electrical stimulation pulse signal transmitted from the processing unit, the signal generation unit forms a waveform of an electrical stimulation pulse signal to be outputted from each electrode into a biphasic rectangular wave including rectangular waves of opposite polarities, and sets a pulse width of the electrical stimulation pulse signal to 0.2 msec. or more and 2 msec. or less.

Abstract: A vision regeneration assisting device for regenerating vision of a patient, comprising: a plurality of electrodes which are stuck and placed into an optic disc of the patient; a storage unit which stores a generation position of a phosphene specific to the patient in association with the first output conditions for the stimulation signal that has caused to generate the phosphene, the storage unit storing various first output conditions for the stimulation signals and the generation positions of the phosphenes caused by the stimulation signals based on the various first output conditions in association with each other; a processor which sets second output conditions for the stimulation signal based on image data obtained by an external photography unit and the generation positions of the phosphenes stored in the storage unit, and converts the obtained image data into data for the stimulation signal based on the set second output conditions.

Abstract: Since high myopia increases the risks of retinal detachment, myopic chorioretinal atrophy, myopic choroidal neovascularization, glaucoma, and cataract, establishment of prophylaxis against the progress of myopia is desired. However, at present, there is no effective prophylaxis or therapy for axial myopia, which is considered to cause high myopia. The present invention, which was completed based on the finding that Rho kinase inhibitors have an inhibitory action on axial length extension, provides a prominently effective prophylactic or therapeutic agent comprising a Rho kinase inhibitor as an active ingredient for axial myopia.

Abstract: A sight regeneration assisting device for regenerating the sight of a patient comprises a plurality of needlelike electrodes each having a pointed distal end and being to be inserted in an optic papilla of a patient's eye in use; and a signal generator connected with the electrodes through a conductive wire to generate an electric stimulus pulse signal to be outputted from the electrodes, each of the electrodes, excepting a predetermined portion including the distal end, being coated with a coating layer made of resin exhibiting good biocompatibility and insulation, and the coating layer being formed with a turn-back retaining portion for retaining the electrode.

Abstract: The present invention relates to therapeutic and/or prophylactic agents for ocular inflammatory disease, which comprise an interleukin 6 (IL-6) receptor inhibitor as an active ingredient.

Abstract: An ophthalmic treatment method for inhibiting death of retinal constitutive cells of an eye by stimulating the cells includes a first step of placing a positive electrode and a negative electrode in such positions outside the eye that the electrodes provide electrical stimulation to the cells, at least one of the electrodes being placed on one of a cornea and sclera of the eye; and a second step of generating an electrical stimulation pulse having an electric current set at 20 ?A or more but not exceeding 300 ?A from each placed electrode.

Abstract: In surgery of the vitreous body in an eyeball of a human body, a burden on and time of a surgeon is suppressed from being spent, a burden on the eyeball of a patient is greatly reduced, and further, the possibility of a complication after the surgery is also lessened. A holding apparatus, which has eyelid opener portions for pulling and opening upper and lower eyelids, a lens ring for holding a surgical contact lens on the eyeball, and connecting portions for connecting the eyelid opener portions with the lens ring of the surgical contact lens so that the surgical contact lens is held on the eyeball, is set on the eyeball of the patient, which makes it unnecessary to stitch of the lens ring on the eyeball.

Abstract: A method for improving visual ability of even a patient's non-operative eye is provided. The electrical stimulation method for improving vision of patient's eyes comprises placing an electrode in one of patient's right and left eyes, and outputting an electrical stimulation pulse signal from the electrode placed in the patient's eye under a predetermined stimulation condition to stimulate cells constituting a retina or optic nerve, thereby improving vision of the other patient's eye with no electrode being placed.

Abstract: A visual restoration aiding device for restoring vision of a patient, comprises: a substrate which will be placed on or under a retina, a choroid or a sclera of a patient's eye; a plurality of electrodes arranged on the substrate for applying electrical stimulation pulse signals to cells constituting the retina; a photographing unit which photographs an object to be recognized by the patient; and a control unit which controls output of the electrical stimulation pulse signals from each electrode based image data captured by the photographing unit. The number of the electrodes placed on the substrate is less than the number of electrodes that can simultaneously output the electrical stimulation pulse signals based on the image data corresponding to one frame.

Abstract: A visual restoration aiding device includes an electrode array (21) having a plurality of electrodes (21a) placed on an outside of a choroid (E2) of a patient's eye (E) to electrically stimulate cells constituting a retina (E3).

Abstract: A vision regeneration assisting device for regenerating vision of a patient, comprising: a plurality of electrodes which are stuck and placed into an optic disc of the patient; a setting unit with which first output conditions for an electrical stimulation pulse signal from at least one of the electrodes are set variably; a storage unit which stores a generation position of a phosphene specific to the patient in association with the first output conditions for the stimulation signal that has caused to generate the phosphene, the storage unit storing various first output conditions for the stimulation signals and the generation positions of the phosphenes caused by the stimulation signals based on the various first output conditions in association with each other; a processor which sets second output conditions for the stimulation signal based on image data obtained by an external photography unit and the generation positions of the phosphenes stored in the storage unit, and converts the obtained image data in

Abstract: A visual restoration aiding device for restoring vision of a patient, comprises: a signal generation unit including a substrate to be placed on an outer side of a choroid of a patient's eye and a plurality of electrodes arranged on the substrate for applying electrical stimulation pulse signals to cells constituting a retina; a photographing unit which photographs an object to be recognized by the patient; and a processing unit which converts image data obtained by the photographing unit to data for electrical stimulation pulse signal and transmits the converted data to the signal generation unit: wherein, based on the data for electrical stimulation pulse signal transmitted from the processing unit, the signal generation unit forms a waveform of an electrical stimulation pulse signal to be outputted from each electrode into a biphasic rectangular wave including rectangular waves of opposite polarities, and sets a pulse width of the electrical stimulation pulse signal to 0.2 msec. or more and 2 msec. or less.

Abstract: An ophthalmic treatment method for inhibiting death of retinal constitutive cells of an eye by stimulating the cells includes a first step of placing a positive electrode and a negative electrode in such positions outside the eye that the electrodes provide electrical stimulation to the cells, at least one of the electrodes being placed on one of a cornea and sclera of the eye; and a second step of generating an electrical stimulation pulse having an electric current set at 20 ?A or more but not exceeding 300 ?A from each placed electrode.

Abstract: A visual restoration aiding device for restoring vision of a patient, comprises: a substrate which will be placed on or under a retina, a choroid or a sclera of a patient's eye; a plurality of electrodes arranged on the substrate for applying electrical stimulation pulse signals to cells constituting the retina; a photographing unit which photographs an object to be recognized by the patient; and a control unit which controls output of the electrical stimulation pulse signals from each electrode based image data captured by the photographing unit. The number of the electrodes placed on the substrate is less than the number of electrodes that can simultaneously output the electrical stimulation pulse signals based on the image data corresponding to one frame.

Abstract: An ophthalmic treatment apparatus includes an electrode which is set on a place to apply electrical stimulation to cells constituting a retina; and an electrical stimulation pulse generator which is connected to the electrode, for generating, from the electrode, a predetermined electrical stimulation pulse whose electric current is set at 20 ?A or more but not exceeding 300 ?A.