Abstract: Disclosed herein are a process for producing mixed crystals of disodium 5?-guanylate and disodium 5?-inosinate which comprises precipitating mixed crystals of disodium 5?-guanylate and disodium 5?-inosinate (I+G mixed crystals) by adding an aqueous mixed solution of disodium 5?-guanylate and disodium 5?-inosinate and a hydrophilic organic solvent at the same time into a crystallization vessel in such manner that the ratio of the hydrophilic organic solvent to the liquid phase in the crystallization vessel is maintained in a range of 30 to 70 vol %, as well as such process for producing I+G mixed crystals wherein said producing of I+G mixed crystals is carried out by seeding crystallization wherein crystals of 5?-IMP2Na or/and I+G mixed crystals are used as seed crystals.

Abstract: Herein is disclosed a method for producing mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate which comprises feeding a mixed solution of disodium 5′-guanylate and disodium 5′-inosinate which solution will become supersaturated at the below-mentioned constant temperature, to a solution or slurry of disodium 5′-guanylate and disodium 5′-inosinate charged in a crystallization bath (lower-temperature bath) and kept at a constant temperature, whereby mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate are deposited from the mixed solution of disodium 5′-guanylate and disodium 5′-inosinate, according to which method 5′-GMP2Na which is difficult to handle due to the properties and powder characteristic of its crystals in particular and 5′-IMP2Na, in the form of crystals which are easy to handle, that is, I+G mixed crystals having a given I/G ratio, can be produced under simple process control and with inexpensi

Abstract: Disclosed herein are a process for producing mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate which comprises precipitating mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate (I+G mixed crystals) by adding an aqueous mixed solution of disodium 5′-guanylate and disodium 5′-inosinate and a hydrophilic organic solvent at the same time into a crystallization vessel in such manner that the ratio of the hydrophilic organic solvent to the liquid phase in the crystallization vessel is maintained in a range of 30 to 70 vol %, as well as such process for producing I+G mixed crystals wherein said producing of I+G mixed crystals is carried out by seeding crystallization wherein crystals of 5′-IMP2Na or/and I+G mixed crystals are used as seed crystals.

Abstract: Herein is disclosed a method for producing mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate which comprises feeding a mixed solution of disodium 5′-guanylate and disodium 5′-inosinate which solution will become supersaturated at the below-mentioned constant temperature, to a solution or slurry of disodium 5′-guanylate and disodium 5′-inosinate charged in a crystallization bath (lower-temperature bath) and kept at a constant temperature, whereby mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate are deposited from the mixed solution of disodium 5′-guanylate and disodium 5′-inosinate, according to which method 5′-GMP2Na which is difficult to handle due to the properties and powder characteristic of its crystals in particular and 5′-IMP2Na, in the form of crystals which are easy to handle, that is, I+G mixed crystals having a given I/G ratio, can be produced under simple process control and with inexpensi