Abstract: Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases.

Abstract: The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(?O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

Abstract: The connected structure includes a plurality of vacuum double pipes and a joint connecting the plurality of vacuum double pipes. Each vacuum double pipe includes an inner pipe and an outer pipe, and a vacuum passage is formed between the inner pipe and the outer pipe. The vacuum passage is open at both ends in an extension direction of the inner pipe and sealed between the both ends. The joint includes an inner pipe joint portion having inner pipe connectors and an outer pipe joint portion having outer pipe connectors. The joint evacuation passage connects the vacuum passages and is sealed between the outer pipe connectors.

Abstract: Provided are diphenyl sulfide derivatives which have excellent S1P3 antagonistic activity and are useful as drugs. Intensive studies have been made for the purpose of creating a compound having S1P3 antagonistic activity. As a result of the intensive studies, it has been found that diphenyl sulfide derivatives represented by general formula (1) have excellent S1P3 antagonistic activity. In general formula (1), R1 is a hydrogen atom or the like; R2 is an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like; X is a methylene group which may be substituted with one or two fluorine atoms, or the like; Y is a hydrogen atom or the like; and Z is a halogen atom.

Abstract: [Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity. [Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.

Abstract: Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.

Abstract: A thermal-type air flow measuring device includes a heat generation heater and a sensor circuit. The heat generation heater is configured to heat a part of intake air drawn into an engine by heat generation upon energization of the heat generation heater. The sensor circuit is configured to at least control the energization of the heat generation heater and to make temperature of the heat generation heater higher than temperature of the heat generation heater at time of the measurement of the flow rate of air when an external signal is inputted into the sensor circuit from outside of the device.

Abstract: An air flow rate measuring apparatus includes a heater and a control circuit. The heater heats a part of an intake air sucked into an engine. The control circuit controls an energization of the heater. The heater has a measuring-mode temperature when a flow rate of the intake air is measured. The control circuit has a heat cleaner which temporarily raises a temperature of the heater higher than the measuring-mode temperature when an energization of the air flow rate measuring apparatus is started.

Abstract: An air flow measuring device includes a housing, flow sensor, and a humidity sensor. The housing defines a bypass flow passage through which intake it passes. A part of intake air is taken into the bypass flow passage to pass through the bypass flow passage. The flow sensor includes a sensing part disposed in the bypass flow passage, and produces a signal which is in accordance with the flow rate of intake air as a result of heat transfer between intake air taken into the bypass flow passage and the sensing part. The humidity sensor includes a sensing part exposed to the intake passage, and projects from an outer wall of the housing into the intake passage. The humidity sensor produces a signal which is in accordance with humidity of intake ail flowing through the intake passage.

Abstract: A thermal type air flow meter, which detects a flow rate of air flowing in an air passage, includes a sensor portion having a heating element in an air passage, a temperature control unit. The temperature control unit includes a first arm serially connecting a first resistive element and a heater temperature detection resistor which detects a temperature of the heating element, a second arm serially connecting a second resistive element and an air temperature detection resistor which detects a temperature of air flowing in the air passage, and a voltage supply unit which supplies first and second voltages respectively to the first and second arms. The voltage supply unit includes a voltage adjusting portion which can adjust at least one of the first and second voltages such that the detection temperature difference between the heater temperature detection resistor and the air temperature detection resistor becomes constant.

Abstract: An air flow measurement device arranged in an intake passage includes a bypass passage having an inlet from which a part of a main flow of an intake air is introduced, and an outlet from which the introduced intake air flows out. A sensor is located in the bypass passage to generate an electrical signal, and the bypass passage communicates with the intake passage through a hole portion. The outlet is open toward a downstream side of the intake passage in a flow direction of the main flow of the intake air. The hole portion is located within an outlet projected area that is provided by projecting an open area of the outlet in straight and toward upstream in the flow direction of the main flow on a projection surface perpendicular to the flow direction of the main flow.

Abstract: An amino alcohol derivative useful as an excellent immunosuppressive agent is provided. As a result of intensive research to create a highly safe compound which has an excellent immunosuppressive activity, it was discovered that an amino alcohol derivative represented by the general formula (1), has excellent immunosuppressive activity.

Abstract: To provide an amino phosphate derivative having an excellent sphingosine-1-phosphate (S1P) receptor modulatory action. As a result of continued intensive research to create a highly safe compound which has an S1P receptor modulatory action, is has been discovered that an amino phosphate derivative represented by the following general formula (1), has a strong S1P receptor modulatory action.

Abstract: Provided are diphenyl sulfide derivatives which have excellent S1P3 antagonistic activity and are useful as drugs. Intensive studies have been made for the purpose of creating a compound having S1P3 antagonistic activity. As a result of the intensive studies, it has been found that diphenyl sulfide derivatives represented by general formula (1) have excellent S1P3 antagonistic activity. In general formula (1), R1 is a hydrogen atom or the like; R2 is an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like; X is a methylene group which may be substituted with one or two fluorine atoms, or the like; Y is a hydrogen atom or the like; and Z is a halogen atom.

Abstract: A flow measuring device includes a flow rate detecting part, an analog/digital conversion part, and a signal processing part. The flow rate detecting part detects a flow rate of air flowing through the passage, and outputs a flow voltage signal, which is a voltage in accordance with the flow rate. The analog/digital conversion part converts the flow voltage signal from the flow rate detecting part into digital data, which is flow digital data. The signal processing part performs calculation processing upon the flow digital data, which includes averaging of a predetermined number of consecutive pieces of the flow digital data, and outputs the averaged flow digital data as a flow rate signal. The predetermined number is equal to or larger than two.

Abstract: A first conductive line, through which a midpoint electric potential of a first series circuit of a bridge circuit is outputted, is branched from a first midpoint connection on a sensor chip. A second conductive line, through which a midpoint electric potential of a second series circuit of the bridge circuit is outputted, is branched from a second midpoint connection on the sensor chip. The output point of the midpoint electric potential of the first series circuit is provided at a midpoint between two temperature sensor resistors, and the first midpoint connection is provided on a center line of a heater resistor. The output point of the midpoint electric potential of the second series circuit is provided at a midpoint between two temperature sensor resistors, and the second midpoint connection is provided on the center line of the heater resistor.

Abstract: A flow meter outputs a frequency signal, which corresponds to an air flow quantity of intake air to be supplied to an engine. In an engine control unit, when a sensed value of the air flow quantity, which is obtained based on the frequency signal, is within an estimated air flow quantity range, which is estimated based on an operational state of the engine, the sensed value of the air flow quantity is determined as a measurement value of the flow meter. In contrast, when the sensed value of the air flow quantity is out of the estimated air flow quantity range, a median of the estimated air flow quantity range is determined as the measurement value of the flow meter.

Abstract: Provided herein are aminoquinolones of formula I and compositions containing the compounds, wherein formula I is The compounds and compositions provided herein are useful in the amelioration or treatment of GSK-3 inhibitors mediated diseases.

Abstract: This invention provides a connected structure of vacuum double pipes. The connected structure comprises a plurality of vacuum double pipes and a joint configured to connect the plurality of vacuum double pipes. The vacuum passage is open at both end in an extension direction of the inner pipe and sealed between the both ends. The joint includes an inner pipe joint unit having inner pipe connectors and an outer pipe joint unit having outer pipe connectors. The evacuation passage is sealed between the outer pipe connectors that connect the vacuum passages of the outer pipes.

Abstract: The present invention provides a novel isoquinoline derivative which is useful as a pharmaceutical agent having a phosphodiesterase inhibitory activity.