Abstract: A method of manufacturing a rectangular battery includes: ironing the blank thereby forming an interim cup including an interim bottom whose area is larger than a bottom plate of the rectangular battery can, an inclined wall tilting upwardly formed continuously from each longitudinal end of the interim bottom, a short side wall formed continuously from the inclined wall, and a long side wall formed continuously from a curved corner formed on each lateral end of the interim bottom; deforming the interim cup such that each boundary between the interim bottom and the inclined wall is displaced toward a longitudinal end of the bottom plate of the rectangular battery can, and a width of the interim bottom is adjusted to a width of the bottom plate of the rectangular battery can; and ironing the short side and long side walls to reduce thicknesses of the short side and long side walls.

Abstract: An object of the present invention is to provide a method for efficiently identifying a polyubiquitinated substrate which is generally not easily identified. The method for identifying a polyubiquitinated substrate includes (1) a step of expressing a trypsin-resistant polyubiquitin chain-binding protein and a ubiquitin ligase in a cell, (2) a step of isolating a complex that contains the trypsin-resistant polyubiquitin chain-binding protein from the cell having undergone the step (1), (3) a step of subjecting the complex isolated by the step (2) to trypsin digestion, and (4) a step of identifying a peptide that has a ubiquitination site from a digested material obtained by the step (3).

Abstract: An object of the present invention is to provide a method for efficiently identifying a polyubiquitinated substrate which is generally not easily identified. The method for identifying a polyubiquitinated substrate includes (1) a step of expressing a trypsin-resistant polyubiquitin chain-binding protein and a ubiquitin ligase in a cell, (2) a step of isolating a complex that contains the trypsin-resistant polyubiquitin chain-binding protein from the cell having undergone the step (1), (3) a step of subjecting the complex isolated by the step (2) to trypsin digestion, and (4) a step of identifying a peptide that has a ubiquitination site from a digested material obtained by the step (3).

Abstract: An antibody has as a target molecule a ubiquitin protein comprising a phosphorylated serine residue at position 65. In addition, a method is provided for specifically detecting Parkinson's disease at an early stage, in which a target molecule is a ubiquitin protein comprising a phosphorylated serine residue at position 65, a pharmaceutical composition for definitively treating or preventing Parkinson's disease, and a method for screening for the pharmaceutical composition.

Abstract: Protein ubiquitylation, an essential post-translational modification, regulates almost every cellular process including protein degradation, protein trafficking, signal transduction, and DNA damage response in eukaryotic cells. The diverse functions of ubiquitylation are thought to be mediated by distinct chain topologies resulting from eight different ubiquitin linkages, chain lengths, and complexities. Currently, ubiquitin linkages are generally thought to be a critical determinant of ubiquitin signaling. However, ubiquitin chain lengths, another key element of ubiquitin signaling, have not been well documented especially in vivo situation during past three decades from the discovery of ubiquitin. The reason of this was simply because no method has been available for determination of ubiquitin chain length in endogenous ubiquitylated substrates. In the present invention, a practical technique for determining the actual length of substrate-attached polyubiquitin chains from biological samples is established.

Abstract: Protein ubiquitylation, an essential post-translational modification, regulates almost every cellular process including protein degradation, protein trafficking, signal transduction, and DNA damage response in eukaryotic cells. The diverse functions of ubiquitylation are thought to be mediated by distinct chain topologies resulting from eight different ubiquitin linkages, chain lengths, and complexities. Currently, ubiquitin linkages are generally thought to be a critical determinant of ubiquitin signaling. However, ubiquitin chain lengths, another key element of ubiquitin signaling, have not been well documented especially in vivo situation during past three decades from the discovery of ubiquitin. The reason of this was simply because no method has been available for determination of ubiquitin chain length in endogenous ubiquitylated substrates. In the present invention, a practical technique for determining the actual length of substrate-attached polyubiquitin chains from biological samples is established.

Abstract: Protein ubiquitylation, an essential post-translational modification, regulates almost every cellular process including protein degradation, protein trafficking, signal transduction, and DNA damage response in eukaryotic cells. The diverse functions of ubiquitylation are thought to be mediated by distinct chain topologies resulting from eight different ubiquitin linkages, chain lengths, and complexities. Currently, ubiquitin linkages are generally thought to be a critical determinant of ubiquitin signaling. However, ubiquitin chain lengths, another key element of ubiquitin signaling, have not been well documented especially in vivo situation during past three decades from the discovery of ubiquitin. The reason of this was simply because no method has been available for determination of ubiquitin chain length in endogenous ubiquitylated substrates. In the present invention, a practical technique for determining the actual length of substrate-attached polyubiquitin chains from biological samples is established.

Abstract: A antibody has as a target molecule a ubiquitin protein comprising a phosphorylated serine residue at position 65. In addition, a method is provided for specifically detecting Parkinson's disease at an early stage, in which a target molecule is a ubiquitin protein comprising a phosphorylated serine residue at position 65, a pharmaceutical composition for definitively treating or preventing Parkinson's disease, and a method for screening for the pharmaceutical composition.

Abstract: A antibody has as a target molecule a ubiquitin protein comprising a phosphorylated serine residue at position 65. In addition, a method is provided for specifically detecting Parkinson's disease at an early stage, in which a target molecule is a ubiquitin protein comprising a phosphorylated serine residue at position 65, a pharmaceutical composition for definitively treating or preventing Parkinson's disease, and a method for screening for the pharmaceutical composition.

Abstract: A headlamp device of a vehicle is configured as follows: A headlamp housing 30 is provided with a shock-absorbing portion 33 which protrudes from the rear wall of the headlamp housing 30 toward the rear of the vehicle, and whose longitudinal section is formed in a U-shape which opens toward the front of the vehicle. The shock-absorbing portion 33 is provided with a lamp mounting foot which protrudes from a posterior wall 33c of the shock-absorbing portion 33 toward the rear of the vehicle, and which has a leading end attached to a vehicle body 2.

Abstract: Protein ubiquitylation, an essential post-translational modification, regulates almost every cellular process including protein degradation, protein trafficking, signal transduction, and DNA damage response in eukaryotic cells. The diverse functions of ubiquitylation are thought to be mediated by distinct chain topologies resulting from eight different ubiquitin linkages, chain lengths, and complexities. Currently, ubiquitin linkages are generally thought to be a critical determinant of ubiquitin signaling. However, ubiquitin chain lengths, another key element of ubiquitin signaling, have not been well documented especially in vivo situation during past three decades from the discovery of ubiquitin. The reason of this was simply because no method has been available for determination of ubiquitin chain length in endogenous ubiquitylated substrates. In the present invention, a practical technique for determining the actual length of substrate-attached polyubiquitin chains from biological samples is established.

Abstract: A headlamp device of a vehicle is configured as follows: A headlamp housing 30 is provided with a shock-absorbing portion 33 which protrudes from the rear wall of the headlamp housing 30 toward the rear of the vehicle, and whose longitudinal section is formed in a U-shape which opens toward the front of the vehicle. The shock-absorbing portion 33 is provided with a lamp mounting foot which protrudes from a posterior wall 33c of the shock-absorbing portion 33 toward the rear of the vehicle, and which has a leading end attached to a vehicle body 2.

Abstract: In an inspection of a substance in which a first region is made of black resin and a second region is made of a metal, a portion surrounding the first region is registered as a first imaging range, and a portion surrounding the second region is registered as a second imaging range. As an imaging condition for the first region, a relatively slow shutter speed is registered such that an image does not become dark. Further, as an imaging condition for the second region, a relatively fast shutter speed is registered such that an image does not have unduly high white levels. As such, the imaging range and condition set by a user are supplied to a CCD camera, and then image processing is performed on a captured image from the CCD camera by an image processing device main body.

Abstract: A printer less susceptible to paper jams, allowing reduction in number of components and having superior printing precision is provided. The printer includes a chassis, a printing portion mounted on the chassis for printing on a sheet of recording paper, a press roller rotatably mounted on the chassis, kept at an approximately constant distance from the printing portion for pressing the sheet of recording paper, a feed roller rotatably mounted on chassis, movable in directions toward and away from the press roller and holding the sheet of recording paper in close contact with the press roller, and a spring urging the feed roller to the press roller. The chassis has a guide portion extended to guide a sheet of recording paper between the press roller and the feed roller.

Abstract: In an inspection of a substance in which a first region is made of black resin and a second region is made of a metal, a portion surrounding the first region is registered as a first imaging range, and a portion surrounding the second region is registered as a second imaging range. As an imaging condition for the first region, a relatively slow shutter speed is registered such that an image does not become dark. Further, as an imaging condition for the second region, a relatively fast shutter speed is registered such that an image does not have unduly high white levels. As such, the imaging range and condition set by a user are supplied to a CCD camera, and then image processing is performed on a captured image from the CCD camera by an image processing device main body.

Abstract: A printer less susceptible to paper jams, allowing reduction in number of components and having superior printing precision is provided. The printer includes a chassis, a printing portion mounted on the chassis for printing on a sheet of recording paper, a press roller rotatably mounted on the chassis, kept at an approximately constant distance from the printing portion for pressing the sheet of recording paper, a feed roller rotatably mounted on chassis, movable in directions toward and away from the press roller and holding the sheet of recording paper in close contact with the press roller, and a spring urging the feed roller to the press roller. The chassis has a guide portion extended to guide a sheet of recording paper between the press roller and the feed roller.

Abstract: A plasma treatment apparatus for treating a surface of a conductive work object is disclosed. When the apparatus operates in a conductive work treating mode, the discharge energy per unit area can be varied by changing the discharge voltage duration and/or by changing the time interval between application of voltage. Further, the application of a variable voltage pulse changes a path of discharge on the effective treatment area of a work object. This results in the surface of the work object being effectively treated all over.