Patents by Inventor Yasushi Sanno
Yasushi Sanno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4153794Abstract: Novel N-benzylpiperazine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are same or different and each stands for a hydrogen atom or an acyl group; R.sup.3 stands for a hydrogen atom, a carbamoyl group, an acyl group which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group which is unsubstituted or substituted by hydroxy, aryl or aminocarbonyl represented by the formula ##STR2## wherein each of R.sup.4 and R.sup.5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclohexyl group, or R.sup.4 and R.sup.5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. These compounds and salts thereof have respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory tract fluid secretion stimulators.Type: GrantFiled: March 1, 1978Date of Patent: May 8, 1979Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Yasushi Sanno
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Patent number: 4151180Abstract: The present invention relates to novel chromone derivatives, which are shown by the following general formula ##STR1## wherein n is 0 or 1, m is 0, 1 or 2 when each of R's represents halogen, nitro, straight or branched alkyl having 1 to 6 carbon atoms, cyclic alkyl having 3 to 6 carbon atoms or butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any two adjacent carbon atoms at positions 5, 6, 7 and 8, --COOR', wherein R' is hydrogen, lower alkyl, aralkyl, carboxamide which may be unsubstituted or substituted by at least one lower alkyl or aralkyl, or amino group which may be unsubstituted or substituted by R'CO--, wherein R' is a straight or branched chain alkyl or aryl, or lower alkyl, aralkyl or aryl, m is 0 or 1 when each of R's represents hydroxy, lower alkoxy or R'COO--, wherein R' is a straight or branched chain alkyl or aryl. The novel derivatives are useful as intermediates for chromones having effective anti-allergic action.Type: GrantFiled: November 18, 1974Date of Patent: April 24, 1979Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Tomonobu Umetani, Yasushi Sanno
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Patent number: 4104402Abstract: Novel aminotetralol compounds of the formula ##STR1## wherein Z.sup.1 and Z.sup.2 are hydrogen or an alkyl group and R.sup.1 is a substituted acyclic hydrocarbon group or a cyclic hydrocarbon group, and their pharmaceutically acceptable salts, have excellent pharmacological activities such as strong bronchodilating activity or .beta.-adrenergic blocking activity. They are useful as medicines, for example, for treatment of asthma or arrhythmia.Type: GrantFiled: November 11, 1976Date of Patent: August 1, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirosada Sugihara, Masazumi Watanabe, Michio Motohashi, Masao Nishikawa, Yasushi Sanno
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Patent number: 4091220Abstract: Novel N-benzylpiperazine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are same or different and each stands for a hydrogen atom or an acyl group; R.sup.3 stands for a hydrogen atom; a carbamoyl group, an acyl group which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group which is unsubstituted or substituted by hydroxy, aryl or aminocarbonyl represented by the formula ##STR2## wherein each of R.sup.4 and R.sup.5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclohexyl group, or R.sup.4 and R.sup.5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. These compounds and salts thereof have respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory track fluid secretion stimulators.Type: GrantFiled: May 3, 1977Date of Patent: May 23, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshihiro Ishiguro, Yasushi Sanno
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Patent number: 4085116Abstract: The present invention relates to novel chromone derivatives having effective antiallergic action with low toxicity, which are shown by the following formula (I) ##STR1## wherein R is hydrogen or lower alkyl and A is ##STR2## (R' is hydrogen or lower alkyl) or ##STR3## and their physiologically acceptable salts.Type: GrantFiled: March 24, 1976Date of Patent: April 18, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Toshihiro Ishiguro, Yasushi Sanno
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Patent number: 4041079Abstract: Novel bicyclic compounds of the general formula: ##STR1## wherein Y stands for --O-- or a methylene group, Z stands for hydrogen or an alkyl group having 1 to 6 carbon atoms and R stands for hydrogen or an alkyl group having 1 to 6 carbon atoms are useful as medicines for treatment of asthma or arrhythmia.Type: GrantFiled: December 13, 1973Date of Patent: August 9, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirosada Sugihara, Michio Motohashi, Masazumi Watanabe, Masao Nishikawa, Yasushi Sanno
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Patent number: 4035512Abstract: Novel aminotetralol compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, acyl derived from carboxylic acid, or a hydrocarbon group which may be substituted; --OZ.sup.1 is hydroxyl which may be protected; Y is hydrogen, acyl, hydroxyl which may be protected, amino which may be substituted, nitro, cyano or halogen; and n is zero, 1 or 2 with a proviso that when Y is hydrogen or hydroxyl which may be protected, n is not zero, and their salts, have excellent pharmacological activities such as strong bronchodilating activity. They are useful as medicines, for example, for treatment of asthma.Type: GrantFiled: June 12, 1975Date of Patent: July 12, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirosada Sugihara, Masazumi Watanabe, Michio Motohashi, Masao Nishikawa, Yasushi Sanno
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Patent number: 4029699Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a C.sub.1-4 alkoxy, R.sub.2 is C.sub.1-4 alkyl and R.sub.3 is C.sub.1-4 alkylthio or pharmaceutically acceptable salts thereof. The compounds of the present invention exhibit excellent choleretic activity.Type: GrantFiled: November 26, 1975Date of Patent: June 14, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadakazu Murata, Akira Nohara, Hirosada Sugihara, Yasushi Sanno
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Patent number: 4017517Abstract: This invention relates to a 3-(trisubstituted benzoyl)-propionic acid and the production thereof.This compound has spasmolytic and choleretic activity.Type: GrantFiled: November 26, 1975Date of Patent: April 12, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadakazu Murata, Akira Nohara, Hirosada Sugihara, Yasushi Sanno
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Patent number: 4010202Abstract: Novel aminotetralol compounds of the formula ##STR1## wherein Z.sup.1 and Z.sup.2 are hydrogen or an alkyl group and R.sup.1 is a substituted acyclic hydrocarbon group or a cyclic hydrocarbon group, and their pharmaceutically acceptable salts, have excellent pharmacological activities such as strong bronchodilating activity or .beta.-adrenergic blocking activity. They are useful as medicines, for example, for treatment of asthma or arrhythmia.Type: GrantFiled: March 4, 1975Date of Patent: March 1, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Hirosada Sugihara, Masazumi Watanabe, Michio Motohashi, Masao Nishikawa, Yasushi Sanno
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Patent number: 3984441Abstract: There are provided compounds of the general formula ##SPC1##Wherein R is a hydroxy, alkyl, acyloxy, halogen, nitro, substituted or unsubstituted amino, alkoxy, carboxy or a group derived from a carboxy group and m is 0, 1 or 2 except where m is 2, the two R groups are both hydroxy groups.The present invention is also concerned with a process for preparing the chromonealdehyde compounds. The chromonealdehyde compounds are characterized by antiallergic properties and are therefore useful as prophylactic and therapeutic agents for allergic asthma, allergic dermatitis and other allergic diseases and also are valuable as intermediates for the synthesis of other pharmaceutical compounds having the chromone nucleus.Type: GrantFiled: November 2, 1972Date of Patent: October 5, 1976Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Nohara, Tomonobu Umetani, Yoshibumi Miyata, Yasushi Sanno
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Patent number: 3943169Abstract: The present invention relates to a compound of the formula: ##SPC1##Wherein R.sub.1 is an alkyl group of 1 to 4 carbons, an alkoxy group of 1 to 4 carbons or hydroxyl, and R.sub.2 and R.sub.3 are either the same or different and may be an alkyl group of 1 to 4 carbons, an alkoxy group of 1 to 4 carbons, hydroxyl, halogen or an alkylthio group of 1 to 4 carbons, or they are, connecting with each other, an alkylenedioxy group of 1 to 3 carbons, with the proviso that when R.sub.1 is an alkoxy group, at least one of R.sub.2 and R.sub.3 is an alkoxy group or an alkylthio group, or R.sub.2 and R.sub.3 are, connecting with each other, an alkylenedioxy group; when R.sub.1 is an alkyl group or hydroxyl, R.sub.2 and R.sub.3 are the same or different and may be an alkoxy group, an alkylthio group or, connecting with each other, an alkylene dioxy group; when R.sub.2 and R.sub.3 are methoxy, R.sub.1 is an alkyl group of 2 or 3 carbons, an alkoxy group of 2 to 4 carbons or hydroxyl, and when R.sub.2 is methyl and R.sub.Type: GrantFiled: September 12, 1972Date of Patent: March 9, 1976Assignee: Takeda Chemical Industries, LtdInventors: Tadakazu Murata, Akira Nohara, Hirosada Sugihara, Yasushi Sanno