Patents by Inventor Yasushi Takebayashi
Yasushi Takebayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10363538Abstract: A substrate for biochips, in which carboxyl groups are immobilized on a substrate whose surface at least is composed of carbon; and a method for producing the substrate are disclosed. The substrate for biochips comprises a substrate whose surface at least is composed of carbon; and an acrylic polymer having free carboxyl groups in the molecular structure thereof, which acrylic polymer is immobilized on the surface of the substrate. The method for producing the substrate comprises irradiating the substrate whose surface at least is composed of carbon with ultraviolet light during the acrylic polymer having free carboxyl groups in the molecular structure thereof contacts the substrate.Type: GrantFiled: October 5, 2017Date of Patent: July 30, 2019Assignee: NIPPON LIGHT METAL COMPANY, LTD.Inventors: Yasushi Takebayashi, Ryo Morishita, Kei Yamaguchi
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Publication number: 20180036705Abstract: A substrate for biochips, in which carboxyl groups are immobilized on a substrate whose surface at least is composed of carbon; and a method for producing the substrate are disclosed. The substrate for biochips comprises a substrate whose surface at least is composed of carbon; and an acrylic polymer having free carboxyl groups in the molecular structure thereof, which acrylic polymer is immobilized on the surface of the substrate. The method for producing the substrate comprises irradiating the substrate whose surface at least is composed of carbon with ultraviolet light during the acrylic polymer having free carboxyl groups in the molecular structure thereof contacts the substrate.Type: ApplicationFiled: October 5, 2017Publication date: February 8, 2018Applicant: Nippon Light Metal Company, Ltd.Inventors: Yasushi TAKEBAYASHI, Ryo MORISHITA, Kei YAMAGUCHI
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Patent number: 9857369Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: GrantFiled: July 22, 2014Date of Patent: January 2, 2018Assignees: HIPEP LABORATORIES, NIPPON LIGHT METAL COMPANY, LTD.Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
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Patent number: 9855542Abstract: A substrate for biochips, in which carboxyl groups are immobilized on a substrate whose surface at least is composed of carbon; and a method for producing the substrate are disclosed. The substrate for biochips comprises a substrate whose surface at least is composed of carbon; and an acrylic polymer having free carboxyl groups in the molecular structure thereof, which acrylic polymer is immobilized on the surface of the substrate. The method for producing the substrate comprises irradiating the substrate whose surface at least is composed of carbon with ultraviolet light during the acrylic polymer having free carboxyl groups in the molecular structure thereof contacts the substrate.Type: GrantFiled: January 7, 2014Date of Patent: January 2, 2018Assignee: NIPPON LIGHT METAL COMPANY, LTD.Inventors: Yasushi Takebayashi, Ryo Morishita, Kei Yamaguchi
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Publication number: 20160216254Abstract: A substrate for biochips, in which contamination of a biologically relevant substance(s) to be immobilized does not occur even when reaction spots on the substrate for biochips are highly densified; and a biochip comprising the same are provided. The substrate for biochips comprises a substrate and a plurality of reaction spots disposed on the substrate. A plurality of grooves, which surround each of the reaction spots individually and independently, are provided on the substrate. On the biochip, a biologically relevant substance(s) is/are immobilized on each of the reaction spots of the substrate for biochips.Type: ApplicationFiled: July 10, 2014Publication date: July 28, 2016Applicant: NIPPON LIGHT METAL COMPANY, LTD.Inventors: Ryo MORISHITA, Yasushi TAKEBAYASHI, Kei YAMAGUCHI
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Publication number: 20150352511Abstract: A substrate for biochips, in which carboxyl groups are immobilized on a substrate whose surface at least is composed of carbon; and a method for producing the substrate are disclosed. The substrate for biochips comprises a substrate whose surface at least is composed of carbon; and an acrylic polymer having free carboxyl groups in the molecular structure thereof, which acrylic polymer is immobilized on the surface of the substrate. The method for producing the substrate comprises irradiating the substrate whose surface at least is composed of carbon with ultraviolet light during the acrylic polymer having free carboxyl groups in the molecular structure thereof contacts the substrate.Type: ApplicationFiled: January 7, 2014Publication date: December 10, 2015Inventors: Yasushi TAKEBAYASHI, Ryo MORISHITA, Kei YAMAGUCHI
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Patent number: 9164082Abstract: A substrate for biochips, which does not induce autofluorescence, which can immobilize a biologically relevant substance(s) easily, which can prevent the undesirable spread of a liquid spot which is added dropwise on the biochips when using the biochips, in which the adhesion between a carbon-containing layer and an aluminum material is high, and which can be produced at lower cost than the known substrate for biochips; a method for producing the substrate; and a biochip including the substrate are disclosed. The substrate for biochips comprises a carbon-coated aluminum material, wherein the carbon-coated aluminum material comprises an aluminum material and a carbon-containing layer formed on at least one surface of the aluminum material, and further comprises an interposing layer which is formed between the aluminum material and the carbon-containing layer, and which interposing layer contains aluminum element and carbon element.Type: GrantFiled: August 22, 2012Date of Patent: October 20, 2015Assignees: TOYO ALUMINIUM KABUSHIKI KAISHA, NIPPON LIGHT METAL COMPANY, LTD.Inventors: Hidetoshi Inoue, Zenya Ashitaka, Hiroyuki Kusai, Yasushi Takebayashi, Ryo Morishita, Yasuo Oka
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Publication number: 20140336081Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: ApplicationFiled: July 22, 2014Publication date: November 13, 2014Applicants: NIPPON LIGHT METAL COMPANY, LTD., HIPEP LABORATORIESInventors: Kiyoshi NOKIHARA, Akiyoshi HIRATA, Yasuo OKA, Yasushi TAKEBAYASHI
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Patent number: 8822607Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: GrantFiled: June 30, 2009Date of Patent: September 2, 2014Assignees: Hipep Laboratories, Nippon Light Metal Company, Ltd.Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi
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Publication number: 20140220316Abstract: A substrate for biochips, which does not induce autofluorescence, which can immobilize a biologically relevant substance(s) easily, which can prevent the undesirable spread of a liquid spot which is added dropwise on the biochips when using the biochips, in which the adhesion between a carbon-containing layer and an aluminum material is high, and which can be produced at lower cost than the known substrate for biochips; a method for producing the substrate; and a biochip including the substrate are disclosed. The substrate for biochips comprises a carbon-coated aluminum material, wherein the carbon-coated aluminum material comprises an aluminum material and a carbon-containing layer formed on at least one surface of the aluminum material, and further comprises an interposing layer which is formed between the aluminum material and the carbon-containing layer, and which interposing layer contains aluminum element and carbon element.Type: ApplicationFiled: August 22, 2012Publication date: August 7, 2014Applicants: NIPPON LIGHT METAL COMPANY, LTD., TOYO ALUMINIUM KABUSHIKI KAISHAInventors: Hidetoshi Inoue, Zenya Ashitaka, Hiroyuki Kusai, Yasushi Takebayashi, Ryo Morishita, Yasuo Oka
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Publication number: 20110152409Abstract: A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.Type: ApplicationFiled: June 30, 2009Publication date: June 23, 2011Inventors: Kiyoshi Nokihara, Akiyoshi Hirata, Yasuo Oka, Yasushi Takebayashi