Abstract: An object of the present invention is induction of CD4-positive T cells from pluripotent stem cells. This object is achieved by production of CD4-positive T cells by introducing a CD4 gene or a gene product thereof into T cells induced from pluripotent stem cells.

Abstract: An information processing apparatus includes a processor configured to: extract, as an inspection target item, product manufacturing information needed for inspection from three-dimensional model data including the product manufacturing information needed when a molded product is manufactured; and decide an inspection method to be used for inspection as to the product manufacturing information as the inspection target item according to information related to the extracted product manufacturing information.

Abstract: An information processing apparatus includes a processor configured to: extract, as an inspection target item, product manufacturing information needed for inspection from three-dimensional model data including the product manufacturing information needed when a molded product is manufactured; and set one or more measurement points at which an inspection target site is to be measured and a number of the one or more measurement points according to information related to the extracted product manufacturing information as the inspection target item.

Abstract: An information processing apparatus includes a processor configured to: determine a relationship between first product manufacturing information and second product manufacturing information included in three-dimensional model data; and generate, on a basis of the determined relationship, information indicating the relationship between the first product manufacturing information and the second product manufacturing information.

Abstract: Provided is a T cell receptor containing, as ? chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 1 to 3, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 4 to 6, as ? chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 7 to 9, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 10 to 12, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24.

Abstract: A pharmaceutical includes helper T cells induced from pluripotent stem cells. The helper T cells include CD4-positive CD40L-highly expressing T cells, dendritic cells, antigen, and cytotoxic T cells CD8-positive T cells. The pharmaceutical can be administered in a method for treating cancer to a patient having cancer cells expressing an antigen specifically recognized by CD4-positive T cells.

Abstract: Provided is a T cell receptor capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24. A T cell receptor capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 28 or a complex of the peptide and HLA-A02. Disclosed T cell receptors are useful in treating or avoiding cancers which are associated with expression of glypican-3.

Abstract: A method for producing a professional antigen-presenting cell, including inducing expression of c-MYC, BMI1, and MDM2 in a myeloid cell (MC) to obtain a proliferative myeloid cell (pMC), and inducing expression of GM-CSF and/or M-CSF in the pMC to obtain a professional antigen-presenting cell (pAPC). The myeloid cell is a myeloid cell differentiated from a pluripotent stem cell.

Abstract: A method of producing helper T cells, comprising: (i) culturing T cells, which have been induced from pluripotent stem cells and into which a CD4 gene or a gene product thereof has been introduced, in a medium containing IL-2 and IL-15; and (ii) isolating CD40L-highly expressing T cells from cells obtained in step (i).

Abstract: An information processing apparatus includes a processor configured to display a relationship object indicating a positional relationship of at least two or more measurement spots in a molded product at a position corresponding to the relationship on a three-dimensional model of the molded product.

Abstract: A management apparatus includes a processor configured to: autonomously collect, even without an instruction from a user, attribute data concerning attributes of a product defined by a three-dimensional shape, in accordance with a collection rule for collecting the attribute data concerning the product, the attribute data being generated in individual process stages before the product is manufactured; associate the collected attribute data with three-dimensional shape data indicating the three-dimensional shape of the product, as attributes of the three-dimensional shape data, in accordance with a superimposition rule which defines association between the three-dimensional shape data and the attribute data concerning the product; and manage the three-dimensional shape data and the attributes of the product.

Abstract: A three-dimensional shape data generation apparatus includes: a processor configured to obtain two-dimensional shape data representing a two-dimensional shape corresponding to a three-dimensional shape of a target to which attribute information is to be assigned, obtain the attribute information of the two-dimensional shape, and assign the obtained attribute information to at least some three-dimensional elements among plural three-dimensional elements representing the three-dimensional shape to generate three-dimensional shape data.

Abstract: A management apparatus includes a processor configured to: autonomously collect, even without an instruction from a user, attribute data concerning attributes of a product defined by a three-dimensional shape, in accordance with a collection rule for collecting the attribute data concerning the product, the attribute data being generated in individual process stages before the product is manufactured; associate the collected attribute data with three-dimensional shape data indicating the three-dimensional shape of the product, as attributes of the three-dimensional shape data, in accordance with a superimposition rule which defines association between the three-dimensional shape data and the attribute data concerning the product; and manage the three-dimensional shape data and the attributes of the product.

Abstract: A three-dimensional shape data generation apparatus includes: a processor configured to obtain two-dimensional shape data representing a two-dimensional shape corresponding to a three-dimensional shape of a target to which attribute information is to be assigned, obtain the attribute information of the two-dimensional shape, and assign the obtained attribute information to at least some three-dimensional elements among plural three-dimensional elements representing the three-dimensional shape to generate three-dimensional shape data.

Abstract: A method of producing helper T cells, comprising: (i) culturing T cells, which have been induced from pluripotent stem cells and into which a CD4 gene or a gene product thereof has been introduced, in a medium containing IL-2 and IL-15; and (ii) isolating CD40L-highly expressing T cells from cells obtained in step (i).

Abstract: Provided is a T cell receptor containing, as ? chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 1 to 3, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 4 to 6, as ? chain complementarity determining regions, respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 7 to 9, or respective amino acid sequences of CDR1 to CDR3 respectively shown in SEQ ID NOs: 10 to 12, and capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24.

Abstract: An object of the present invention is induction of CD4-positive T cells from pluripotent stem cells. This object is achieved by production of CD4-positive T cells by introducing a CD4 gene or a gene product thereof into T cells induced from pluripotent stem cells.