Abstract: Provided is a work machine capable of achieving both low fuel consumption and ensuring of workability. The work machine is configured to, in a state where an output of an engine or hydraulic pump has increased to an increase threshold (S12: Yes) with the rotational speed being at a first rotational speed (S11: Yes), raise the rotational speed from the first rotational speed to a second rotational speed (S13); in a process of raising the rotational speed to the second rotational speed, output, to a regulator, a signal instructing reduction in the discharge rate (S14) so as to keep the output of the engine or hydraulic pump constant; and after the rotational speed has reached the second rotational speed, output, to the regulator, a signal instructing increase in the discharge rate (S16) so as to make the output of the engine or hydraulic pump have a value corresponding to a request load.

Abstract: The object of the present invention resides in provision of a construction machine in which a hydraulic cylinder can be driven in a high efficiency by an accumulator. To this end, the construction machine including: a hydraulic cylinder; a first accumulator that accumulates return fluid from the hydraulic cylinder with a first set pressure; a tank that stores hydraulic fluid therein; a first hydraulic pump that delivers the hydraulic fluid sucked from the tank; a hydraulic actuator that is driven by the first hydraulic pump; and a second accumulator that accumulates return fluid from the hydraulic actuator with a second set pressure, includes a first control valve placed in a first hydraulic line that connects the first accumulator and the hydraulic cylinder to each other, and a second control valve placed in a second hydraulic line that connects the second accumulator and the hydraulic cylinder to each other. The second set pressure is set to a value higher than that of the first set pressure.

Abstract: A work machine includes: a hydraulic actuator that is driven by a hydraulic fluid from a hydraulic pump; an open-center directional control valve that is arranged on a center bypass line, and controls a flow of the hydraulic fluid to be supplied to the hydraulic actuator; a CB cut valve arranged between a directional control valve and a hydraulic working fluid tank on the center bypass line; and a machine controller that controls an opening of the CB cut valve. The machine controller restricts the opening of the CB cut valve when operation on the hydraulic actuator is in a fine operation state in which the operation on the hydraulic actuator is within a predetermined range representing a region of fine operation, and the fine operation state is continued longer than a predetermined period, and fully opens the CB cut valve otherwise.

Abstract: A work machine includes a hydraulic pump that is driven by an engine and delivers a pressurized fluid, a hydraulic actuator that is operated by the pressurized fluid delivered by the hydraulic pump, a hydraulic accumulator device that accumulates the pressurized fluid discharged from the hydraulic actuator, a differential pressure control valve that is disposed between the hydraulic actuator and the hydraulic accumulator device and generates a differential pressure across the differential pressure control valve between a pressure of the hydraulic actuator and a pressure of the hydraulic accumulator device, a pressure sensor that senses the pressure of the hydraulic accumulator device, and a controller that controls the differential pressure control valve on the basis of a sensing result of the pressure sensor.

Abstract: The present invention provides vaccine compositions for protection against human rotaviral disease designed for use in particular areas of the world. Human× bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined with other VP7 serotypes typically found in the area of interest into a multivalent formulation which provides a high degree of infectivity and immunogenicity. Methods and an administration protocol for producing an immunogenic response without producing an increased risk of intussusception are also provided.

Abstract: The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.

Abstract: The present invention provides rotavirus reassortant immunogenic compositions based on a porcine rotavirus. In particular, porcine rotavirus Gottfried strain-based single VP7 or VP4 gene substitutions which can provide (i) an attenuation phenotype of a porcine rotavirus in humans and (ii) antigenic coverage for G serotypes 1, 2, 3, 4, 5, 6, 8, 9 and 10 and P serotype 1A[8], 1B[4] and 2A[6]. The compositions have been demonstrated to induce consistent levels of neutralizing antibodies against rotavirus specificities which are of global epidemiologic importance. Porcine rotavirus-based reassortant rotavirus compositions induce neutralizing antibodies against P1A[8] and P2A[6] VP4 serotypes which may provide an advantage over rhesus- or bovine-based reassortant vaccines since the VP4s of the latter vaccines do not evoke antibodies capable of neutralizing the P1A[8], or P2A[6] VP4.

Abstract: The present invention provides vaccine compositions for protection against human rotaviral disease designed for use in particular areas of the world. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined with other VP7 serotypes typically found in the area of interest into a multivalent formulation which provides a high degree of infectivity and immunogenicity. Methods and an administration protocol for producing an immunogenic response without producing an increased risk of intussusception are also provided.

Abstract: The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating mutations which produce virus having a cold-adapted (ca) and temperature sensitive (ts) phenotype. The attenuated strains are used in methods for stimulating the immune system of an individual to induce protection against human rotavirus by administration of the ca attenuated rotavirus.

Abstract: The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating mutations which produce virus having a cold-adapted (ca) and temperature sensitive (ts) phenotype. The attenuated strains are used in methods for stimulating the immune system of an individual to induce protection against human rotavirus by administration of the ca attenuated rotavirus.

Abstract: According to the present invention, there are provided an input terminal, an output terminal, an a.c. generating circuit and a voltage-anomaly detecting circuit. Power supplied to the input terminal is outputted from the output terminal based on an output produced from the voltage-anomaly detecting circuit. When the voltage of the supplied power is abnormal, a.c. power produced from the a.c. generating circuit is outputted from the output terminal. Further, a boosting circuit, a rectifying circuit and a capacitor are provided. The a.c. generating circuit is constructed so as to produce a.c. power from a charged voltage of capacitor. Owing to this construction, a power supply apparatus having a function for compensating for changes in voltage can be provided which is small in size and is inexpensive.

Abstract: A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.

Abstract: The present invention discloses a vaccine for the prevention of rotavirus caused diseases in humans. The vaccine is prepared from attenuated, immunogenic rhesus rotavirus which has been characterized to be antigenically similar, if not identical, to human rotavirus serotype 3.

Abstract: The present invention discloses a vaccine for the prevention of rotavirus caused diseases in humans. The vaccine is prepared from attenuated, immunogenic rhesus rotavirus which has been characterized to be antigenically similar, if not identical, to human rotavirus serotype 3.

Abstract: This invention relates to a method for the propagation of feline infectious peritonits (FIP) virus by means of tissue culture. It has been found that FIP virus can be propagated in organ cultures, for example, using feline tracheal rings or small intestine, as well as monolayer cell cultures, for example, using feline kidney, lung or embryo cell cultures.

Abstract: The nuclear resonance signal obtained from the sample is stored in a memory circuit and the stored signal is then repeatedly read out. A periodic function which is derived as a result of the transformation of a triangular wave into a trapezoidal one, is used for the Fourier transformation of the repeatedly read-out signal. The adverse influence of the transient phenomenon in the h-f impulse signal on the resultant spectrum is eliminated by stopping the Fourier transformation only during the initial portion of the read-out period of the memory circuit.