Abstract: The connection support device includes a rod-shaped member insertable into respective hollow portions of two or more cell structures, the rod-shaped member being inserted into the hollow portions, the rod-shaped member including a circular cross section having an outer diameter capable of adhering to inner surfaces of the cell structures when the rod-shaped member contracts after maturing, and a total length longer than a sum of respective lengths of the two or more cell structures, and two presser devices including clamp portions capable of being fixed to the rod-shaped member by clamping and fitting to the rod-shaped member, the rod-shaped member being made of a material with oxygen permeability.

Abstract: The cell structure fixing and removing system includes: an alignment base made of a silicone resin, the alignment base including a flat sticking surface to which needles with skewed cell aggregates are to be stuck; and a cell structure removing tool placed on the sticking surface between the alignment base and the cell aggregate, the cell structure removing tool including: a frame extending to correspond to an outline of the sticking surface, the frame including a puncture opening in middle, a bottom surface of the frame forming an alignment surface parallel to the sticking surface; and a porous sheet stretched and arranged on the alignment surface to close the puncture opening of the frame, the porous sheet allowing penetration by the needle, wherein an outline edge of the puncture opening in the alignment surface of the frame of the cell structure removing tool is located in the outline of the sticking surface.

Abstract: The cell structure manufacturing system including a cabinet being a closed space capable of maintaining an inside at a high cleanness, a cultivation plate supplying device configured to supply one cultivation plate of a plurality of cultivation plates to a conveying device in a cultivation plate supplying area, a transfer device including a cell aggregate injection device configured to discharge and transfer, and a sticking device including a needle-like body clamping mechanism configured to remove one needle-like body from a needle-like body supplying mechanism storing a plurality of needle-like bodies and perform gripping of the one needle-like body.

Abstract: The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.

Abstract: The connection support device includes a rod-shaped member insertable into respective hollow portions of two or more cell structures, the rod-shaped member being inserted into the hollow portions, the rod-shaped member including a circular cross section having an outer diameter capable of adhering to inner surfaces of the cell structures when the rod-shaped member contracts after maturing, and a total length longer than a sum of respective lengths of the two or more cell structures, and two presser devices including clamp portions capable of being fixed to the rod-shaped member by clamping and fitting to the rod-shaped member, the rod-shaped member being made of a material with oxygen permeability.

Abstract: A dose distribution calculation device of the invention is characterized by including: a beam information storing unit (a measured energy storing unit, a measured electric-charge storing unit, a measured beam-central axis storing unit), in which, when particle beam information of a particle beam generated by a particle beam therapy system is measured by a measuring device in confirmative radiation in which the particle beam is radiated to a phantom as a substitute for a treatment target, the thus-measured particle beam information is stored; and a total dose calculation unit for calculating a radiation dose distribution (a total dose distribution) on the basis of the measured particle beam information (a measured energy, a measured beam quantity (a measured number of electric charges), a measured position of beam central axis).

Abstract: The cell structure producing apparatus capable of properly piercing a cell aggregate and a cell tray are demanded. The object of the present invention is achieved by a cell structure producing apparatus that includes a movable needle-shaped body and sticks and penetrates a cell aggregate held on a cell tray, wherein the cell tray includes a frame having an opening, and a porous member that is supported at the opening by the frame and on which the cell aggregate is placeable, and a tip of the needle-shaped body is capable of penetrating through the porous member when the needle-shaped body sticks and penetrates the cell aggregate.

Abstract: The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.

Abstract: A dose distribution calculation device of the invention is characterized by including: a beam information storing unit (a measured energy storing unit, a measured electric-charge storing unit, a measured beam-central axis storing unit), in which, when particle beam information of a particle beam generated by a particle beam therapy system is measured by a measuring device in confirmative radiation in which the particle beam is radiated to a phantom as a substitute for a treatment target, the thus-measured particle beam information is stored; and a total dose calculation unit for calculating a radiation dose distribution (a total dose distribution) on the basis of the measured particle beam information (a measured energy, a measured beam quantity (a measured number of electric charges), a measured position of beam central axis).

Abstract: A method of manufacturing a radio frequency accelerator that accelerates charged particles injected into a second-stage linear accelerator from a first-stage linear accelerator includes a step of setting a value of a power distribution factor R for the power distributor to supply radio frequency power to the second-stage linear accelerator and a value of a ratio L/? of a length L of the matching section between the outlet of the first-stage linear accelerator and the inlet of the second-stage linear accelerator to the angular frequency ? of the radio frequency power, so that a charged particle beam is extracted from the second-stage linear accelerator over a range of the total radio frequency power wider than a widest allowable range among allowable total radio frequency power ranges determined for each phase of charged particles on the basis of phase acceptance of the second-stage accelerator.

Abstract: A method of manufacturing a radio frequency accelerator that accelerates charged particles injected into a second-stage linear accelerator from a first-stage linear accelerator includes a step of setting a value of a power distribution factor R for the power distributor to supply radio frequency power to the second-stage linear accelerator and a value of a ratio L/? of a length L of the matching section between the outlet of the first-stage linear accelerator and the inlet of the second-stage linear accelerator to the angular frequency ? of the radio frequency power, so that a charged particle beam is extracted from the second-stage linear accelerator over a range of the total radio frequency power wider than a widest allowable range among allowable total radio frequency power ranges determined for each phase of charged particles on the basis of phase acceptance of the second-stage accelerator.