Patents by Inventor Yasuto Tanabe

Yasuto Tanabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene encoding MNR2 and uses thereof
    Patent number: 7192916
    Abstract: This invention provides isolated nucleic acids encoding a motor neuron restricted MNR2 protein, and a homeobox HB9 protein. Also provided are purified MNR2 and HB9 proteins, antibodies recognizing these proteins, transgenic animals expressing these proteins, and functionally equivalent analogs of these proteins. Finally, methods are disclosed for inducing differentiation of somatic motor neurons, and for treating diseases related to the lack of normally functioning motor neurons, neurodegenerative diseases, acute nervous system injury, and neuromuscular disease.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: March 20, 2007
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Thomas M. Jessell, Yasuto Tanabe, Christopher William
  • Gene encoding MNR2 and uses thereof
    Patent number: 7074771
    Abstract: This invention provides an isolated nucleic acid molecule encoding a motor neuron restricted pattern, MNR2, protein. This invention provides an isolated nucleic acid molecule of at least 15 contiguous nucleotides capable of specifically hybridizing with a unique sequence included within the sequence of the nucleic acid molecule encoding a MNR2 protein. This invention provides a purified MNR2 protein, a polyclonal and monoclonal antibody directed to an epitope of an MNR2 protein. This invention provides a method of inducing differentiation somatic motor neurons which comprises expressing MNR2 protein in any neural progenitor cells. This invention provides a transgenic animal which expresses an MNR2 protein. This invention provides a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: July 11, 2006
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Thomas M. Jessell, Yasuto Tanabe, Christopher William
  • Gene encoding MNR2 and uses thereof
    Publication number: 20030104374
    Abstract: This invention provides isolated nucleic acids encoding a motor neuron restricted MNR2 protein, and a homeobox HB9 protein. Also provided are purified MNR2 and HB9 proteins, antibodies recognizing these proteins, transgenic animals expressing these proteins, and functionally equivalent analogs of these proteins. Finally, methods are disclosed for inducing differentiation of somatic motor neurons, and for treating diseases related to the lack of normally functioning motor neurons, neurodegenerative diseases, acute nervous system injury, and neuromuscular disease.
    Type: Application
    Filed: March 29, 2001
    Publication date: June 5, 2003
    Inventors: Thomas M. Jessell, Yasuto Tanabe, Christopher William
  • Gene encoding MNR2 and uses thereof
    Publication number: 20020197678
    Abstract: This invention provides an isolated nucleic acid molecule encoding a motor neuron restricted pattern, MNR2, protein. This invention provides an isolated nucleic acid molecule of at least 15 contiguous nucleotides capable of specifically hybridizing with a unique sequence included within the sequence of the nucleic acid molecule encoding a MNR2 protein. This invention provides a purified MNR2 protein, a polyclonal and monoclonal antibody directed to an epitope of an MNR2 protein. This invention provides a method of inducing differentiation somatic motor neurons which comprises expressing MNR2 protein in any neural progenitor cells. This invention provides a transgenic animal which expresses an MNR2 protein. This invention provides a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 11, 2002
    Publication date: December 26, 2002
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Thomas M. Jessell, Yasuto Tanabe, Christopher William
  • Gene encoding MNR2 and uses thereof
    Patent number: 6387656
    Abstract: This invention provides an isolated nucleic acid molecule encoding a motor neuron restricted pattern, MNR2, protein. This invention provides an isolated nucleic acid molecule of at least 15 contiguous nucleotides capable of specifically hybridizing with a unique sequence included within the sequence of the nucleic acid molecule encoding a MNR2 protein. This invention provides a purified MNR2 protein, a polyclonal and monoclonal antibody directed to an epitope of an MNR2 protein. This invention provides a method of inducing differentiation somatic motor neurons which comprises expressing MNR2 protein in any neural progenitor cells. This invention provides a transgenic animal which expresses an MNR2 protein. This invention provides a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: May 14, 2002
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Thomas M. Jessell, Yasuto Tanabe, Christopher William