Patents by Inventor Yasutomo Imai
Yasutomo Imai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11571462Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis and psoriatic arthritis.Type: GrantFiled: July 30, 2020Date of Patent: February 7, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Brian F. Volkman, Anthony E. Getschman, Sam T. Hwang, Yasutomo Imai, Francis C. Peterson
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Publication number: 20200360479Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis and psoriatic arthritis.Type: ApplicationFiled: July 30, 2020Publication date: November 19, 2020Inventors: Brian F. Volkman, Anthony E. Getschman, Sam T. Hwang, Yasutomo Imai, Francis C. Peterson
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Patent number: 10738095Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis, inflammatory disorders and autoimmune disease.Type: GrantFiled: May 31, 2016Date of Patent: August 11, 2020Assignee: The Medical College of Wisconsin, Inc.Inventors: Brian F. Volkman, Anthony E. Getschman, Sam T. Hwang, Yasutomo Imai, Francis C. Peterson
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Publication number: 20180237486Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis, inflammatory disorders and autoimmune disease.Type: ApplicationFiled: May 31, 2016Publication date: August 23, 2018Inventors: Brian F. Volkman, Anthony E. Getschman, Sam T. Hwang, Yasutomo Imai, Francis C. Peterson
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Patent number: 9949465Abstract: The present invention provides a transgenic non-human mammal retaining, in a specifically expressible state, a DNA encoding IL-33 in the skin, and having one or more features selected from the group consisting of (1) spontaneous onset of dermatitis, (2) increase in the number of inflammatory cells, (3) increase in total IgE concentration, histamine concentration, cytokine concentration and/or chemokine concentration, and (4) increase in scratching time, under SPF (specific pathogen free) breeding conditions, as compared to a corresponding non-transgenic non-human mammal, and the like.Type: GrantFiled: April 30, 2014Date of Patent: April 24, 2018Assignees: Hyogo College of Medicine, Mie UniversityInventors: Kiyofumi Yamanishi, Hitoshi Mizutani, Yasutomo Imai, Tomohiro Yoshimoto, Kenji Nakanishi
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Publication number: 20160057978Abstract: The present invention provides a transgenic non-human mammal retaining, in a specifically expressible state, a DNA encoding IL-33 in the skin, and having one or more features selected from the group consisting of (1) spontaneous onset of dermatitis, (2) increase in the number of inflammatory cells, (3) increase in total IgE concentration, histamine concentration, cytokine concentration and/or chemokine concentration, and (4) increase in scratching time, under SPF (specific pathogen free) breeding conditions, as compared to a corresponding non-transgenic non-human mammal, and the like.Type: ApplicationFiled: April 30, 2014Publication date: March 3, 2016Inventors: Kiyofumi YAMANISHI, Hitoshi MIZUTANI, Yasutomo IMAI, Tomohiro YOSHIMOTO, Kenji NAKANISHI
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Patent number: 8263305Abstract: Provided is a method for producing a toner having excellent particle size distribution and storage stability. The method set forth in the present specification is a method for producing a toner by aggregating and fusing base microparticles whose main component is a binder resin including anionic groups, wherein an aggregate is produced by aggregating the base microparticles in a base microparticle suspension, in a presence of a non-ionic surfactant such that a surface tension of an aqueous solution thereof is not lower than 45 mN/m at any concentration at or above a critical micelle concentration, and the toner is produced through fusion of the aggregate. According to this method, drops in a glass transition temperature of the toner can be curbed, and the toner having excellent storage stability and good particle size distribution can be obtained.Type: GrantFiled: March 30, 2010Date of Patent: September 11, 2012Assignee: Brother Kogyo Kabushiki KaishaInventors: Jun Ikami, Masateru Kawamura, Yasutomo Imai
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Patent number: 8119319Abstract: The present teaching provides a method for producing a positive charging toner that can exhibit stable charge characteristics. According to the present teaching, a positive charging toner is produced by preparing a base particle suspension having a conductivity not higher than 70 ?S/cm and comprising base particles that are obtained by mixing and emulsifying an aqueous medium and a resin solution containing the polyester resin; producing toner base particles by mixing the base particle suspension with a charge control resin microparticle suspension containing charge control resin microparticles; causing the charge control resin microparticles to adhere to the surfaces of the base particles; and washing the toner base particles.Type: GrantFiled: March 31, 2009Date of Patent: February 21, 2012Assignee: Brother Kogyo Kabushiki KaishaInventors: Masateru Kawamura, Yasutomo Imai
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Publication number: 20100248115Abstract: Provided is a method for producing a toner having excellent particle size distribution and storage stability. The method set forth in the present specification is a method for producing a toner by aggregating and fusing base microparticles whose main component is a binder resin including anionic groups, wherein an aggregate is produced by aggregating the base microparticles in a base microparticle suspension, in a presence of a non-ionic surfactant such that a surface tension of an aqueous solution thereof is not lower than 45 mN/m at any concentration at or above a critical micelle concentration, and the toner is produced through fusion of the aggregate. According to this method, drops in a glass transition temperature of the toner can be curbed, and the toner having excellent storage stability and good particle size distribution can be obtained.Type: ApplicationFiled: March 30, 2010Publication date: September 30, 2010Applicant: BROTHER KOGYO KABUSHIKI KAISHAInventors: Jun IKAMI, Masateru KAWAMURA, Yasutomo IMAI
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Publication number: 20090246681Abstract: The present teaching provides a method for producing a positive charging toner that can exhibit stable charge characteristics. According to the present teaching, a positive charging toner is produced by preparing a base particle suspension having a conductivity not higher than 70 ?S/cm and comprising base particles that are obtained by mixing and emulsifying an aqueous medium and a resin solution containing the polyester resin; producing toner base particles by mixing the base particle suspension with a charge control resin microparticle suspension containing charge control resin microparticles; causing the charge control resin microparticles to adhere to the surfaces of the base particles; and washing the toner base particles.Type: ApplicationFiled: March 31, 2009Publication date: October 1, 2009Applicant: Brother Kogyo Kabushiki KaishaInventors: Masateru KAWAMURA, Yasutomo Imai
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Patent number: 5808449Abstract: A method for detecting islanding operation of a rotating-machine type dispersed generator. The dispersed generator is interconnected with a main electric source through a circuit breaker to constitute an electric power system. The estimating method is implemented as follows: (a) changing electric power of the electric power system; (b) detecting frequency component of the electric power; and (c) deciding that an islanding operation of the dispersed generator is executed if the change of the frequency component becomes greater than a predetermined value. With this method, it becomes possible to detect the islanding operation of the dispersed generator even if the power flow at the interconnecting circuit breaker is generally zero.Type: GrantFiled: May 31, 1996Date of Patent: September 15, 1998Assignees: Kabushiki Kaisha Meidensha, The Tokyo Electric Power CompanyInventors: Yoshiyuki Hirayama, Nobuhiro Kuroda, Takaaki Kai, Toshiaki Fujimoto, Haruo Sasaki, Yasutomo Imai, Jun Motohashi, Hirotoshi Kaneda