Patents by Inventor Yasutoshi Nishikawa

Yasutoshi Nishikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240252714
    Abstract: A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process, wherein the biodegradable fiber comprises 30 to 50 wt % of PLLGA resin and 70 to 50 wt % of ?-TCP fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates, wherein the ?-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the ?-TCP fine particles are covered by the PLLGA resin so that the ?-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and wherein the bone-regeneration material is sterilized by using radiation sterilization with gamma ray.
    Type: Application
    Filed: April 9, 2024
    Publication date: August 1, 2024
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY, ORTHOREBIRTH CO., LTD.
    Inventors: Toshihiro Kasuga, Yasutoshi Nishikawa
  • Patent number: 11969521
    Abstract: A bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber containing PLGA by using electrospinning. A PLGA resin is heated in a kneader to soften until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added and mixed with the softened PLGA resin, while the blade of the kneader rotates. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved in a solvent to prepare a spinning solution. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: April 30, 2024
    Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY, ORTHOREBIRTH CO., LTD.
    Inventors: Toshihiro Kasuga, Yasutoshi Nishikawa
  • Publication number: 20230233740
    Abstract: A method of producing an osteoinductive bone graft formed of a plurality of electrospun biodegradable fibers is disclosed. The method includes preparing a fibrous scaffold material formed of the plurality of electrospun biodegradable fibers, wherein the plurality of electrospun biodegradable fibers are entangled with each other to form a cotton-wool like structure having inter-fiber spaces forming a microenvironment for cell growth therein, and immersing the fibrous scaffold in a solution containing BMP-2 so that the BMP-2 is bound to the calcium particles exposed on the surface of the fibers. Area of binding site for BMP-2 on calcium particles exposed on a surface of the electrospun biodegradable fibers is adjusted by an amount of the calcium particles contained in the electrospun biodegradable fibers.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 27, 2023
    Inventors: Luis ALVAREZ, Yasutoshi NISHIKAWA, Hiroyuki TAIRA
  • Publication number: 20200289703
    Abstract: A bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber containing PLGA by using electrospinning. A PLGA resin is heated in a kneader to soften until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added and mixed with the softened PLGA resin, while the blade of the kneader rotates. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved in a solvent to prepare a spinning solution. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
    Type: Application
    Filed: April 3, 2020
    Publication date: September 17, 2020
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY, ORTHOREBIRTH CO., LTD.
    Inventors: Toshihiro Kasuga, Yasutoshi Nishikawa
  • Patent number: 10646616
    Abstract: A bone-regeneration material that contains calcium phosphate particles in biodegradable fibers of PLGA manufactured by electrospinning. A PLGA resin is heated in a kneader until the resin viscosity becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added while the blade is rotated. The mixture is kneaded by continuous rotation of the blade in the heated state to disperse the calcium phosphate fine particles to obtain a composite having calcium phosphate fine particles dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by agitation for a prescribed duration to prepare a spinning solution in which the calcium phosphate fine particles are dispersed. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 12, 2020
    Assignees: National University Corporation Nagoya Institute of Technology, Orthorebirth Co., Ltd.
    Inventors: Toshihiro Kasuga, Yasutoshi Nishikawa
  • Publication number: 20180280569
    Abstract: A bone-regeneration material that contains calcium phosphate particles in biodegradable fibers of PLGA manufactured by electrospinning. A PLGA resin is heated in a kneader until the resin viscosity becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added while the blade is rotated. The mixture is kneaded by continuous rotation of the blade in the heated state to disperse the calcium phosphate fine particles to obtain a composite having calcium phosphate fine particles dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by agitation for a prescribed duration to prepare a spinning solution in which the calcium phosphate fine particles are dispersed. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
    Type: Application
    Filed: April 28, 2017
    Publication date: October 4, 2018
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY, ORTHOREBIRTH CO.LTD.
    Inventors: Toshihiro Kasuga, Yasutoshi Nishikawa
  • Publication number: 20180021485
    Abstract: The present invention addresses the problem of providing a drug formulation material with which localized sustained release of a drug at any site in the body is possible, and which has good bioabsorption and is absorbed and broken down by the body after sustained release of the drug. A drug formulation material that has an exceedingly high sustained release effect, and that solves the foregoing problem, was successfully developed by dissolving a biodegradable resin and a drug in a solvent to prepare a spinning solution, and spinning fibers from the spinning solution by electrospinning.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 25, 2018
    Applicant: ORTHOREBIRTH CO., LTD.
    Inventors: Yasutoshi Nishikawa, Masashi Makita, Naoki Osada