Patents by Inventor Yasutsugu Ueda

Yasutsugu Ueda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-[[4-fluoro-2-(5-methy-1H-1,2,4-triazol-1-yl)phenyl]methyl]-4-,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide as an HIV integrase inhibitor
    Patent number: 7511037
    Abstract: The invention encompasses a series of bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: March 31, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Timothy P. Connolly, Mark R. Krystal, John D. Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret E. Sorenson, Yasutsugu Ueda, Michael A. Walker
  • Composition and antiviral of substituted azaindoleoxoacetic piperazine derivatives
    Patent number: 7501420
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: March 10, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Zhongxing Zhang, Nicholas A. Meanwell, John F. Kadow, Zhiwei Yin, Qiufen May Xue, Alicia Regueiro-Ren, John D. Matiskella, Yasutsugu Ueda
  • HIV integrase inhibitors: cyclic pyrimidinone compounds
    Patent number: 7419969
    Abstract: The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 2, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Timothy P. Connolly, Yasutsugu Ueda
  • COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES
    Publication number: 20080119480
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: January 17, 2008
    Publication date: May 22, 2008
    Inventors: Tao Wang, Zhongxing Zhang, Nicholas Meanwell, John Kadow, Zhiwei Yin, Qiufen Xue, Alicia Regueiro-Ren, John Matiskella, Yasutsugu Ueda
  • Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
    Patent number: 7354924
    Abstract: This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: April 8, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Zhongxing Zhang, Nicholas A. Meanwell, John F. Kadow, Zhiwei Yin, Qiufen May Xue, Alicia Regueiro-Ren, John D. Matiskella, Yasutsugu Ueda
  • HIV Integrase Inhibitors
    Publication number: 20080004265
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: June 26, 2007
    Publication date: January 3, 2008
    Inventors: Michael A. Walker, Chen Li, Katharine A. Grant-Young, John D. Matiskella, B. Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Carl Ouellet, Annapurna Pendri, Roger Remillard, Yasutsugu Ueda, Ting T. Yin
  • HIV INTEGRASE INHIBITORS
    Publication number: 20070129379
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: November 17, 2006
    Publication date: June 7, 2007
    Inventors: B. Narasimhulu Naidu, Yasutsugu Ueda, Timothy Connolly
  • HIV integrase inhibitors
    Publication number: 20070111984
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 17, 2007
    Inventors: B. Naidu, Yasutsugu Ueda, John Matiskella, Michael Walker, Jacques Banville, Francis Beaulieu, Carl Ouellet, Serge Plamondon
  • HIV integrase inhibitors
    Publication number: 20070111985
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: November 10, 2006
    Publication date: May 17, 2007
    Inventors: B. Naidu, Margaret Sorenson, Yasutsugu Ueda, John Matiskella, Michael Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Patent number: 7176196
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: February 13, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Timothy P. Connolly, Mark R. Krystal, John D. Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret E. Sorenson, Yasutsugu Ueda, Michael A. Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Patent number: 7173022
    Abstract: The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: February 6, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Jacques Banville, John D. Matiskella, Serge Plamondon, Yasutsugu Ueda
  • Bicyclic heterocycles as HIV integrase inhibitors
    Patent number: 7157447
    Abstract: The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: January 2, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Jacques Banville, Francis Beaulieu, Timothy P. Connolly, Mark R. Krystal, John D. Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret E. Sorenson, Yasutsugu Ueda, Michael A. Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20060276466
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 7, 2006
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • HIV integrase inhibitors
    Patent number: 7135467
    Abstract: Compounds useful for treating HIV are disclosed having the general formula wherein R1, R2, and B are as defined in the specification. Compositions containing the compounds and methods for using the compounds to inhibit HIV are also disclosed.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: November 14, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Walker, Hatice Belgin Gulgeze, Narasimhulu B. Naidu, Margaret E. Sorenson, Yasutsugu Ueda, John Matiskella
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20060199956
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: November 29, 2005
    Publication date: September 7, 2006
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • HIV integrase inhibitors: cyclic pyrimidinone compounds
    Publication number: 20060106007
    Abstract: The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed.
    Type: Application
    Filed: November 14, 2005
    Publication date: May 18, 2006
    Inventors: B. Naidu, Timothy Connolly, Yasutsugu Ueda
  • O-derivatized nocathiacin derivatives
    Patent number: 7022667
    Abstract: The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, B. Narasimhulu Naidu, Margaret E. Sorenson, Alicia Regueiro-Ren, Timothy P. Connolly, John D. Matiskella, Oak K. Kim, Yunhui Zhang, Dane M. Springer, Jason Goodrich, Yasutsugu Ueda, Joanne J. Bronson
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20050267105
    Abstract: The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: May 11, 2005
    Publication date: December 1, 2005
    Inventors: B. Naidu, Jacques Banville, Francis Beaulieu, Timothy Connolly, Mark Krystal, John Matiskella, Carl Ouellet, Serge Plamondon, Roger Remillard, Margaret Sorenson, Yasutsugu Ueda, Michael Walker
  • Bicyclic heterocycles as HIV integrase inhibitors
    Publication number: 20050267131
    Abstract: The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Application
    Filed: May 26, 2005
    Publication date: December 1, 2005
    Inventors: B. Naidu, Jacques Banville, John Matiskella, Serge Plamondon, Yasutsugu Ueda
  • Prodrugs of piperazine and substituted piperidine antiviral agents
    Publication number: 20050209246
    Abstract: This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 22, 2005
    Inventors: Yasutsugu Ueda, Timothy Connolly, John Kadow, Nicholas Meanwell, Tao Wang, Chung-Pin Chen, Kap-Sun Yeung, Zhongxing Zhang, David Leahy, Shawn Pack, Nachimuthu Soundararajan, Pierre Sirard, Kathia Levesque, Dominique Thoraval