Abstract: An object of the present invention is to provide a combined pharmaceutical formulation obtained by combining a liposome composition and an immune checkpoint inhibitor, in which gemcitabine is encapsulated in a dissolved state in liposomes in the liposome composition. According to the present invention, there is provided a pharmaceutical formulation including (A) a liposome composition in combination with (B) an immune checkpoint inhibitor, in which the liposome composition includes liposomes each having an inner water phase, and an aqueous solution constituting an outer water phase and having the liposomes dispersed therein, gemcitabine is encapsulated in a dissolved state in the liposomes, and the liposome composition and the immune checkpoint inhibitor are administered simultaneously or sequentially.

Abstract: A lower end plate includes: bolt holes through which bolts penetrate; a lower discharge valve; a lower discharge-valve accommodating recessed portion into which the lower discharge valve is accommodated; and a lower discharge-chamber recessed portion. A lower end plate cover is provided with a bulging portion. A lower end-plate cover chamber is formed by the lower discharge-valve accommodating recessed portion, the lower discharge-chamber recessed portion, and the bulging portion. Refrigerant passage holes include main refrigerant passage holes provided on the lower discharge-chamber recessed portion, and sub-refrigerant passage holes provided between the bolt hole and the lower discharge-valve accommodating recessed portion away from the lower discharge-valve accommodating recessed portion. The bulging portion is, in a cross section orthogonal to a rotating shaft, formed so as to overlap with at least a part of each of the main refrigerant passage holes and the sub-refrigerant passage holes.

Abstract: A compression part of a rotary compressor includes an intermediate partition plate that is arranged between an upper cylinder and a lower cylinder, an upper vane that sections an upper cylinder chamber formed within the upper cylinder into an upper suction chamber and an upper compression chamber, and a lower vane that sections a lower cylinder chamber formed within the lower cylinder into a lower suction chamber and a lower compression chamber. The intermediate partition plate is formed with an injection hole that injects a liquid refrigerant into the upper compression chamber and the lower compression chamber and an injection passage that supplies the liquid refrigerant to the injection hole. The injection passage is formed along a straight line that does not cross a rotary shaft insertion hole into which a rotary shaft is inserted.

Abstract: In a rotary compressor, a lower end plate includes a lower discharge valve that opens and closes a lower discharge hole, a lower discharge-valve accommodating recessed portion in which the lower discharge valve is accommodated, and a lower discharge-chamber recessed portion that is formed so as to overlap with the lower discharge hole side of the lower discharge-valve accommodating recessed portion and communicates with a refrigerant passage hole. A lower end plate cover is formed in a flat-plate shape and is provided with a bulging portion having a portion facing the lower discharge hole. An upper end-plate cover chamber is formed by the lower discharge-valve accommodating recessed portion, the lower discharge-chamber recessed portion, and the bulging portion. The bulging portion has a volume of 1/18 or greater and 1/9 or less of a total of air volumes of an upper compression chamber and a lower compression chamber.

Abstract: An object of the present invention is to provide a combined pharmaceutical formulation obtained by combining a liposome composition and an immune checkpoint inhibitor, in which gemcitabine is encapsulated in a dissolved state in liposomes in the liposome composition. According to the present invention, there is provided a pharmaceutical formulation including (A) a liposome composition in combination with (B) an immune checkpoint inhibitor, in which the liposome composition includes liposomes each having an inner water phase, and an aqueous solution constituting an outer water phase and having the liposomes dispersed therein, gemcitabine is encapsulated in a dissolved state in the liposomes, and the liposome composition and the immune checkpoint inhibitor are administered simultaneously or sequentially.

Abstract: In a rotary compressor, a lower end plate cover is formed in a shape of a flat plate, and has a through hole that is provided to penetrate in the thickness direction of the lower end plate cover and that communicates with a communication groove. When a sectional area of the communication groove which passes through a center line of a rotation shaft, and is on a section along the rotation shaft direction is S1 [mm2], an area in which the through hole and the communication groove overlap each other on a plane orthogonal to the rotation shaft is S2 [mm2], and an excluding capacity of a lower cylinder chamber is V [cc], each of 0.10?(S2/V)?0.50, and 1.0?(S2/S1)?7.0 is satisfied.

Abstract: In a rotary compressor, a lower end plate includes a lower discharge valve that opens and closes a lower discharge hole, a lower discharge-valve accommodating recessed portion in which the lower discharge valve is accommodated, and a lower discharge-chamber recessed portion that is formed so as to overlap with the lower discharge hole side of the lower discharge-valve accommodating recessed portion and communicates with a refrigerant passage hole. A lower end plate cover is formed in a flat-plate shape and is provided with a bulging portion having a portion facing the lower discharge hole. An upper end-plate cover chamber is formed by the lower discharge-valve accommodating recessed portion, the lower discharge-chamber recessed portion, and the bulging portion. The bulging portion has a volume of 1/18 or greater and 1/9 or less of a total of air volumes of an upper compression chamber and a lower compression chamber.

Abstract: A compression part of a rotary compressor includes an intermediate partition plate that is arranged between an upper cylinder and a lower cylinder, an upper vane that sections an upper cylinder chamber formed within the upper cylinder into an upper suction chamber and an upper compression chamber, and a lower vane that sections a lower cylinder chamber formed within the lower cylinder into a lower suction chamber and a lower compression chamber. The intermediate partition plate is formed with an injection hole that injects a liquid refrigerant into the upper compression chamber and the lower compression chamber and an injection passage that supplies the liquid refrigerant to the injection hole. The injection passage is formed along a straight line that does not cross a rotary shaft insertion hole into which a rotary shaft is inserted.

Abstract: A lower end plate includes: bolt holes through which bolts penetrate; a lower discharge valve; a lower discharge-valve accommodating recessed portion into which the lower discharge valve is accommodated; and a lower discharge-chamber recessed portion. A lower end plate cover is provided with a bulging portion. A lower end-plate cover chamber is formed by the lower discharge-valve accommodating recessed portion, the lower discharge-chamber recessed portion, and the bulging portion. Refrigerant passage holes include main refrigerant passage holes provided on the lower discharge-chamber recessed portion, and sub-refrigerant passage holes provided between the bolt hole and the lower discharge-valve accommodating recessed portion away from the lower discharge-valve accommodating recessed portion. The bulging portion is, in a cross section orthogonal to a rotating shaft, formed so as to overlap with at least a part of each of the main refrigerant passage holes and the sub-refrigerant passage holes.

Abstract: In a rotary compressor, S1>S3, S2>S3, and S2?>S3? are satisfied when a sectional area of a refrigerant path hole on a lower endplate is S1, a sectional area of the refrigerant path hole in a lower cylinder is S2, a sectional area of the refrigerant path hole on an intermediate partition plate is S3, an area in which a section of the refrigerant path hole on the lower end plate and a section of the refrigerant path hole in the lower cylinder overlap each other is S2?, and an area in which a section of the refrigerant path hole in the lower cylinder and a section of the refrigerant path hole on the intermediate partition plate overlap each other is S3?.

Abstract: In a rotary compressor, a refrigerant path hole communicates with a lower discharge chamber concave portion while at least a part thereof overlaps the lower discharge chamber concave portion, is positioned between a lower vane groove and a first insertion hole in a lower cylinder, and is configured of a plurality of holes which are disposed between the upper vane groove and the first insertion hole in the upper cylinder, and a sectional area of a cross section which is closest to the lower vane groove and the upper vane groove of the plurality of holes is the smallest compared to the sectional area of the cross section of the other holes.

Abstract: A compressor includes: an annular cylinder; a rotation shaft which is rotated by the motor; a piston which revolves along an inner circumferential surface of the cylinder, and forms a cylinder chamber on the inside of the cylinder; a vane which protrudes to the inside of the cylinder chamber from a vane groove provided in the cylinder, and divides the cylinder chamber into an inlet chamber and a compression chamber by abutting against the piston; and an injection hole which injects a liquid refrigerant to the inside of the compression chamber. The center of the injection hole is disposed to be within a fan-like range of which a center angle is equal to or less than 40° toward a side opposite to a connection position between the compressor housing and the inlet unit from a center line of the vane groove in the circumferential direction of the rotation shaft.

Abstract: Provided are an injection preparation which includes: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent A which is selected from the group consisting of cysteine and a salt thereof, and of which the content is 0.001 mass % to 0.1 mass % with respect to the total mass of the aqueous composition, thioglycerol of which the content is 0.001 mass % to 0.1 mass % with respect to the total mass of the aqueous composition, and an aqueous solvent of which the content is greater than or equal to 50 mass % with respect to the total mass of the aqueous composition, and a container which seals the aqueous composition, in which the concentration of oxygen in gas within the container which seals the aqueous composition is less than or equal to 2.0 volume %, and a method for producing the injection preparation.

Abstract: At least three axis direction through-holes arranged at equal intervals in the circumferential direction are provided in a rotor laminated steel plate and a rotor end plate. The rotor laminated steel plate and the rotor end plate are fixed with three rivets for passing through the axis direction through-holes. A balance weight formed of one laminated metal plate is fixed to the one rotor end plate with two rivets of the three rivets. A balance weight formed of the other laminated metal plate is integrated by caulking and has a projection formed thereon and fixed to the other rotor end plate with the remaining single rivet. The projection is engaged with a recess or a through-hole provided in the other rotor end plate so that the balance weight is positioned to the other rotor end plate.

Abstract: Provided are an injection preparation which include: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent which is selected from the group consisting of ascorbic acid, an ascorbic acid derivative, and salts thereof, and the content of which is 0.0001 mass % to 0.5 mass % with respect to the total mass of the aqueous composition in terms of ascorbic acid, and an aqueous solvent of greater than or equal to 50 mass % with respect to the total mass of the aqueous composition; and a container which encloses the aqueous composition, in which the concentration of oxygen in gas within the container which encloses the aqueous composition is less than or equal to 0.2 volume %, and a method for producing the injection preparation.

Abstract: Provided is a composition for percutaneous absorption containing testosterone and one or more organic solvents selected from the group consisting of propylene glycol, 1,3-butylene glycol, dipropylene glycol and polyethylene glycol, in which a total content of the organic solvents with respect to a total amount of the composition for percutaneous absorption is from 60% by mass to 90% by mass, and in which a content of a monohydric alcohol having 2 to 4 carbon atoms with respect to the total amount of the composition for percutaneous absorption is equal to or less than 10% by mass.

Abstract: In a rotary compressor, S1>S3, S2>S3, and S2?>S3? are satisfied when a sectional area of a refrigerant path hole on a lower endplate is S1, a sectional area of the refrigerant path hole in a lower cylinder is S2, a sectional area of the refrigerant path hole on an intermediate partition plate is S3, an area in which a section of the refrigerant path hole on the lower end plate and a section of the refrigerant path hole in the lower cylinder overlap each other is S2?, and an area in which a section of the refrigerant path hole in the lower cylinder and a section of the refrigerant path hole on the intermediate partition plate overlap each other is S3?.

Abstract: In a rotary compressor, a refrigerant path hole communicates with a lower discharge chamber concave portion while at least a part thereof overlaps the lower discharge chamber concave portion, is positioned between a lower vane groove and a first insertion hole in a lower cylinder, and is configured of a plurality of holes which are disposed between the upper vane groove and the first insertion hole in the upper cylinder, and a sectional area of a cross section which is closest to the lower vane groove and the upper vane groove of the plurality of holes is the smallest compared to the sectional area of the cross section of the other holes.

Abstract: Provided are an injection preparation which include: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent which is selected from the group consisting of ascorbic acid, an ascorbic acid derivative, and salts thereof, and the content of which is 0.0001 mass % to 0.5 mass % with respect to the total mass of the aqueous composition in terms of ascorbic acid, and an aqueous solvent of greater than or equal to 50 mass % with respect to the total mass of the aqueous composition; and a container which encloses the aqueous composition, in which the concentration of oxygen in gas within the container which encloses the aqueous composition is less than or equal to 0.2 volume %, and a method for producing the injection preparation.

Abstract: An aqueous ophthalmic composition includes a carbonic anhydrase inhibitor; at least one cellulose derivative selected from the group consisting of hydroxypropylmethyl cellulose acetate succinate and carboxymethylethyl cellulose; and water.