Abstract: Provided is a bio-hybrid material that does not cause elution of nickel ions and has an excellent endothelialization ability, a production method therefor, and a stent. The bio-hybrid material (101) used includes an alloy part (11) free of Ni, an organic acid (12) having two or more active esters, and a cytokine (13). The alloy part (11) free of Ni forms an ester bond with the organic acid (12), and the organic acid (12) and the cytokine (13) are immobilized via an amide bond.

Abstract: A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30% by mass of Cr, from 0.97 to 2% by mass of Mo, and from 0.5 to 1% by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.

Abstract: Provided is a method of rolling/drawing a nickel-free high-nitrogen stainless steel material, the method including: an intermediate annealing process S11 in which a nickel-free high-nitrogen stainless steel material made of a fine grain structure having a maximum crystal grain size of 30 ?m or less is annealed at a temperature of 900° C. or higher and 1000° C. or lower and then is air-cooled to room temperature; a rolling/drawing process S12 in which the nickel-free high-nitrogen stainless steel material is extended while being thinned or being reduced in diameter; and a final solution treatment process S13 in which the nickel-free high-nitrogen stainless steel material is heated to a temperature of 1200° C. or higher and 1400° C. or lower and then is air-cooled to room temperature.

Abstract: A nickel-free stainless steel stent using a stainless steel which does not substantially contain Ni in the stainless steel, has a metal allergy onset-preventing effect, and is excellent in terms of precision workability, strength, and ductility, is provided. The nickel-free stainless steel stent is characterized by using a stainless steel containing, as a chemical composition, from 15 to 30% by mass of Cr, from 0.97 to 2% by mass of Mo, and from 0.5 to 1% by mass of N, with the remainder being Fe, and optionally containing inevitable impurities.

Abstract: Provided is a bio-hybrid material that does not cause elution of nickel ions and has an excellent endothelialization ability, a production method therefor, and a stent. The bio-hybrid material (101) used includes an alloy part (11) free of Ni, an organic acid (12) having two or more active esters, and a cytokine (13). The alloy part (11) free of Ni forms an ester bond with the organic acid (12), and the organic acid (12) and the cytokine (13) are immobilized via an amide bond.

Abstract: Disclosed is a biocompatible device surface-coated on the base material thereof with a biocompatible polymer layer having antithrombogenicity and endothelialization activity, and embedded in or attached to a living body for use. The polymer layer comprises a polymer matrix formed by the crosslinking of a cell-adhesive peptide-containing polymer.

Abstract: On a method of welding a high nitrogen containing stainless steel using, as a base metal, a high nitrogen stainless steel containing nitrogen at or above a solubility equilibrated with N2 at 1 atm when melted, a novel welding method keeping a weld metal composition from supersaturation of N in a molten state, having a sufficient corrosion resistance in an average composition of the weld metal under sea water circumstance and capable of maintaining mechanical characteristics and corrosion resistance comparable with those of a base metal is provided, wherein welding is conducted while setting a composition of a welding material and a dilution rate to be defined latter so as to satisfy the following two relations (A) and (B): 1 % ⁢ N p × D ≦ 0.028 × ( % ⁢   ⁢ Cr p × D + % ⁢   ⁢ Cr ′ × ( 1 - D ) ) + 0.