Abstract: This invention provides compositions and methods for preventing or treating a malignant tumor in a mammal in need thereof, by administering to the mammal a therapeutically effective amount of a composition comprising RNAi molecules, which RNAi molecules can be active in reducing expression of Hsp47, or a combination of RNAi molecules active for Hsp47 and p21.

Abstract: There is provided a liquid ejection device including a head for ejecting a liquid, a liquid containing unit, a liquid filler, and a pressure adjusting unit, in which the liquid containing unit includes a sealed housing and a flexible member provided in the housing, the housing includes a first containing space communicating with the head and a second containing space partitioned from the first containing space through use of the flexible member, the first containing space contains the liquid, and the liquid filler is filled into the second containing space, the pressure adjusting unit communicates with the second containing space, and adjusts the pressure of the liquid filler filled into the second containing space so as to maintain a negative pressure with respect to the head.

Abstract: A liquid ejection head includes a liquid ejection substrate and a liquid reservoir. The liquid ejection substrate includes a plurality of liquid ejection sections. The liquid ejection sections include pressure chambers configured to hold liquid and ejection ports communicating with the pressure chambers. The pressure chambers each include a pressure unit configured to apply pressure to the liquid in each of the pressure chambers. The pressed liquid is ejected through the ejection ports. The liquid reservoir is in contact with a back of the liquid ejection substrate opposite to the ejection ports. The liquid reservoir is partitioned into at least one common liquid channel and a first common liquid chamber. The common liquid channel communicates with one of inlets and outlets of the plurality of pressure chambers. The first common liquid chamber communicates with another of the inlets and the outlets.

Abstract: A liquid discharge apparatus including a liquid discharge head having a substrate, plural pressure chambers two-dimensionally provided on one surface of the substrate, a discharge port, a pressure generating unit to discharge liquid through the discharge port and a flow path connected to the pressure chamber which are provided correspondingly to each pressure chamber, a common liquid chamber provided on the other surface of the substrate, and plural supply paths provided between adjacent pressure chambers and connected to the common liquid chamber; a moving unit to relatively move the liquid discharge head and a recording object; and a driving unit to drive the pressure generating unit. Flow paths respectively corresponding to the pressure chambers adjacent to the supply paths are connected to the supply paths. The driving unit outputs drive signals to the pressure generating units respectively corresponding to the pressure chambers connected to the supply paths at different timings.

Abstract: A liquid ejection apparatus including: a liquid ejection head including two-dimensionally arranged pressure chambers, and corresponding ejection ports. On a surface on which the ejection ports are arranged, when a relative movement direction of a recording material is x, the direction perpendicular to the relative movement is y, a pitch of pixels is d, and m and n are different odd numbers of 3 or greater, the ejection ports are arranged in a manner such that md and nd are repeated alternately as the distance between the ejection ports adjoining in the y direction, and such that the ejection port arrays extending substantially linearly in an oblique direction to the x and y directions on an xy plane are formed. The ejection port arrays are constituted by (m+n)/2 ejection ports, and the ejection ports adjoining in the ejection port arrays are displaced by 2d in the y direction.

Abstract: A liquid discharge head including plural liquid discharge portions each including a discharge port for discharging liquid, plural discharge ports forming a discharge port array; a common liquid supply flow path extending adjacent to the discharge port array on one side of the discharge port array; and a common liquid collection flow path extending adjacent to the discharge port array on the other side of the discharge port array. Each liquid discharge portion includes a pressure chamber having the discharge port, and a piezoelectric element facing the discharge port. The pressure chamber includes an inlet and an outlet end portion respectively connected to the common liquid supply and collection flow paths, and has an elongated shape connecting the inlet and outlet end portions. A plurality of inlet and outlet end portions are respectively arranged along the common liquid supply flow path and the common liquid collection flow path.

Abstract: A liquid ejection apparatus including: a liquid ejection head including two-dimensionally arranged pressure chambers, and corresponding ejection ports. On a surface on which the ejection ports are arranged, when a relative movement direction of a recording material is x, the direction perpendicular to the relative movement is y, a pitch of pixels is d, and m and n are different odd numbers of 3 or greater, the ejection ports are arranged in a manner such that and and nd are repeated alternately as the distance between the ejection ports adjoining in the y direction, and such that the ejection port arrays extending substantially linearly in an oblique direction to the x and y directions on an xy plane are formed. The ejection port arrays are constituted by (m+n)/2 ejection ports, and the ejection ports adjoining in the ejection port arrays are displaced by 2d in the y direction.

Abstract: An imprint apparatus of the present invention that molds and cures an imprint material on a substrate using a mold to form a pattern on the substrate. The imprint apparatus includes a supply unit configured to supply a gas into a gap between the imprint material on the substrate and the mold. The supply unit is configured to supply a mixed gas in which a permeable gas, which permeates at least one of the mold, the imprint material and the substrate, and a condensable gas, which is liquefied under a pressure generated by the molding, is mixed with each other.

Abstract: A method for generating supply pattern data of an imprint material formed by using a mold is provided. The method includes obtaining, for each of a plurality of different cleaning methods, information concerning of a shape change in a pattern portion of the mold caused by cleaning the pattern portion of the mold. The method further includes generating, based on the obtained information concerning of the shape change corresponding to the cleaning method, the supply pattern data corresponding to the number of cleaning operations.

Abstract: A method of manufacturing an ejection orifice member includes: preparing a substrate including a first layer, a second layer, and a third layer, the first layer protruding in a first direction crossing a principal surface of the substrate, the second and third layers being formed on the first direction side of the first layer, the preparing a substrate including forming the second layer to follow a contour of a first direction side surface of the first layer, and then forming the third layer on a surface of the second layer which protrudes on the first direction side; performing plating using the second layer as a seed to form a fourth layer on the first direction side of the second layer; removing the third layer from the fourth layer to form a hole as the ejection orifice in the fourth layer; and thinning the fourth layer at least around the hole.

Abstract: An ink jet apparatus includes a plurality of actuators that discharge a liquid from a discharge port according to a driving signal input to an input terminal; a driving selector that outputs a drive switch control signal; a plurality of drive switches that connect or disconnect the input terminal of the actuator and a driving signal source according to the drive switch control signal for the actuator, and allow the driving signal to pass therethrough and input the driving signal to the input terminal when the input terminal and the driving signal source are connected; a detection circuit that detects a voltage of the input terminal when being connected to the input terminal; and a plurality of detection switches that connect or disconnect the input terminal of the actuator and the detection circuit on the basis of the drive switch control signal or the driving signal passed through the drive switch.

Abstract: A positioning apparatus for a moving object includes: a driving unit including a stator and a movable element connected to the moving object via a connecting member; a chassis which includes an opening which allows movement of the connecting member upon driving of the movable element, and an exhaust outlet which includes end exhaust outlets arranged at first and second ends of the driving range of the movable element; an exhaust unit which exhausts a gas in the chassis; and a controller which controls the exhaust unit so that an amount of exhaust from the end exhaust outlet arranged at the first end becomes larger when the movable element is driven toward the first end on a side of the first end of the driving range than when the movable element is positioned at the center of the driving range.

Abstract: A liquid discharge apparatus comprises a head having an discharge port surface on which a discharge port is provided for discharging a liquid, and a liquid moving unit arranged apart from the discharge port surface and configured to be movable along the discharge port surface, wherein, the liquid moving unit moves a liquid on the discharge port surface to a collecting position in which the discharge port is not provided, with a moving of the liquid moving unit.

Abstract: There is provided a liquid ejection device including a head for ejecting a liquid, a liquid containing unit, a liquid filler, and a pressure adjusting unit, in which the liquid containing unit includes a sealed housing and a flexible member provided in the housing, the housing includes a first containing space communicating with the head and a second containing space partitioned from the first containing space through use of the flexible member, the first containing space contains the liquid, and the liquid filler is filled into the second containing space, the pressure adjusting unit communicates with the second containing space, and adjusts the pressure of the liquid filler filled into the second containing space so as to maintain a negative pressure with respect to the head.

Abstract: An ink jet apparatus includes a plurality of actuators discharge a liquid from a discharge port according to a driving signal input to an input terminal; a driving selector that outputs a drive switch control signal; a plurality of drive switches connect or disconnect the input terminal of the actuator and a driving signal source according to the drive switch control signal for the actuator, and allow the driving signal to pass therethrough and input the driving signal to the input terminal when the input terminal and the driving signal source are connected; a detection circuit that detects a voltage of the input terminal when being connected to the input terminal; and a plurality of detection switches connect or disconnect the input terminal of the actuator and the detection circuit, on the basis of the drive switch control signal or the driving signal passed through the drive switch.

Abstract: A method of manufacturing an ejection orifice member includes: preparing a substrate including a first layer, a second layer, and a third layer, the first layer protruding in a first direction crossing a principal surface of the substrate, the second and third layers being formed on the first direction side of the first layer, the preparing a substrate including forming the second layer to follow a contour of a first direction side surface of the first layer, and then forming the third layer on a surface of the second layer which protrudes on the first direction side; performing plating using the second layer as a seed to form a fourth layer on the first direction side of the second layer; removing the third layer from the fourth layer to form a hole as the ejection orifice in the fourth layer; and thinning the fourth layer at least around the hole.

Abstract: An exposure apparatus which projects a pattern of an original onto a substrate via a liquid to expose the substrate, includes a substrate stage which holds the substrate and moves, the substrate stage including a peripheral member arranged to surround a region in which the substrate is arranged, the peripheral member having a holding surface which holds the liquid, wherein a trench which traps the liquid is formed in the peripheral member, and the trench is arranged to surround the region in which the substrate is arranged, and includes a bottom portion, an inner-side surface extending from the holding surface toward the bottom portion, and an outer-side surface, the inner-side surface having a slant which increases stepwise or continuously in a direction away from the holding surface, and the outer-side surface is provided with a spattering preventing portion which prevents spattering of the liquid trapped by the trench.

Abstract: An imprint apparatus of the present invention that molds and cures an imprint material on a substrate using a mold to form a pattern on the substrate. The imprint apparatus includes a supply unit configured to supply a gas into a gap between the imprint material on the substrate and the mold. The supply unit is configured to supply a mixed gas in which a permeable gas, which permeates at least one of the mold, the imprint material and the substrate, and a condensable gas, which is liquefied under a pressure generated by the molding, is mixed with each other.

Abstract: There is provided an inkjet apparatus capable of adjusting pressure in an inkjet head to a predetermined slightly negative pressure without limitations on the installation location of a pressure adjustment unit and without stopping the flow of liquid. The inkjet apparatus includes an inkjet head for discharging ink droplets and an ink tank for retaining liquid to the inkjet head. The inkjet apparatus further includes a liquid feeding unit communicating with the inkjet head and configured to feed the liquid in the ink tank to the inkjet head by reducing the pressure in the inkjet head, an open-close valve configured to open or close a flow channel connecting the inkjet head and the liquid feeding unit, and a pressure adjustment unit configured to open or close the open-close valve according to a pressure difference between inside and outside of the flow channel to adjust the pressure in the inkjet head.

Abstract: An imprint apparatus of the present invention that molds and cures an imprint material on a substrate using a mold to form a pattern on the substrate. The imprint apparatus includes a supply unit configured to supply a gas into a gap between the imprint material on the substrate and the mold. The supply unit is configured to supply a mixed gas in which a permeable gas, which permeates at least one of the mold, the imprint material and the substrate, and a condensable gas, which is liquefied under a pressure generated by the molding, is mixed with each other.