Patents by Inventor Yasuyuki Yokosaki

Yasuyuki Yokosaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-INTEGRIN ALPHA-11 MONOCLONAL ANTIBODY AND USE THEREOF
    Publication number: 20230065153
    Abstract: The present invention provides a novel anti-integrin ?11 monoclonal antibody that may treat a fibrotic disease. An aspect of the present invention is an anti-integrin ?11 monoclonal antibody which inhibits binding between an integrin ?11 and collagen.
    Type: Application
    Filed: March 1, 2019
    Publication date: March 2, 2023
    Inventors: Yasuyuki YOKOSAKI, Norihisa NISHIMICHI
  • Fibrosis suppression by inhibiting integrin ?-8 ?-1 function
    Patent number: 10822418
    Abstract: Novel and effective anti-fibrosis agents are obtained. An anti-fibrosis agent containing an antagonist for integrin ?8?1 is used. In addition, used is an antagonist containing an anti-integrin ?8?1 antibody that specifically binds to at least one amino acid in a cap subdomain of an integrin ?8 chain and a periphery thereof. Also, used is an anti-fibrosis agent containing an anti-integrin ?8?1 antibody that specifically binds to R120 of an integrin ?8 chain and a periphery thereof or S132 and a periphery thereof. Note that the above antagonists may each be an anti-integrin ?8?1 antibody capable of binding to any of integrins ?8?1 derived from a human, mouse, and rat.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: November 3, 2020
    Assignee: Hiroshima University
    Inventors: Yasuyuki Yokosaki, Norihisa Nishimichi
  • FIBROSIS SUPPRESSION BY INHIBITING INTEGRIN ALPHA-8 BETA-1 FUNCTION
    Publication number: 20150064187
    Abstract: Novel and effective anti-fibrosis agents are obtained. An anti-fibrosis agent containing an antagonist for integrin ?8?1 is used. In addition, used is an antagonist containing an anti-integrin ?8?1 antibody that specifically binds to at least one amino acid in a cap subdomain of an integrin ?8 chain and a periphery thereof. Also, used is an anti-fibrosis agent containing an anti-integrin ?8?1 antibody that specifically binds to R120 of an integrin ?8 chain and a periphery thereof or S132 and a periphery thereof. Note that the above antagonists may each be an anti-integrin ?8?1 antibody capable of binding to any of integrins ?8?1 derived from a human, mouse, and rat.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 5, 2015
    Inventors: Yasuyuki Yokosaki, Norihisa Nishimichi
  • Integrin alpha 8-beta 1-specific monoclonal antibody
    Patent number: 8658770
    Abstract: [Object] To obtain an anti-integrin ?8?1 antibody which binds to integrin ?8?1 derived from mammals of different species. Also, to obtain an anti-integrin ?8?1 antibody which inhibits binding between integrin ?8?1 and its ligand. [Solution] Anti-integrin ?8?1 antibodies which bind to integrin ?8?1 derived from mammals of different species have been obtained. In addition, inhibitors, which contain an anti-integrin ?8?1 antibody, of binding between integrin ?8?1 and its ligand have been obtained.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: February 25, 2014
    Assignee: Hiroshima University
    Inventors: Haruo Matsuda, Norihisa Nishimichi, Yoshiko Tateishi, Yasuyuki Yokosaki
  • INTEGRIN ALPHA 8-BETA 1-SPECIFIC MONOCLONAL ANTIBODY
    Publication number: 20120237530
    Abstract: [Object] To obtain an anti-integrin ?8?1 antibody which binds to integrin ?8?1 derived from mammals of different species. Also, to obtain an anti-integrin ?8?1 antibody which inhibits binding between integrin ?8?1 and its ligand. [Solution] Anti-integrin ?8?1 antibodies which bind to integrin ?8?1 derived from mammals of different species have been obtained. In addition, inhibitors, which contain an anti-integrin ?8?1 antibody, of binding between integrin ?8?1 and its ligand have been obtained.
    Type: Application
    Filed: October 19, 2010
    Publication date: September 20, 2012
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Haruo Matsuda, Norihisa Nishimichi, Yoshiko Tateishi, Yasuyuki Yokosaki
  • ANTI-OSTEOPONTIN ANTIBODY AND USE THEREOF
    Publication number: 20080069815
    Abstract: An anti-osteopontin antibody which inhibits the binding of an integrin recognizing RGD sequence to osteopontin or its fragment, and which inhibits the binding of an integrin recognizing SVVYGLR sequence or sequence equivalent thereto to osteopontin or its fragment. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.
    Type: Application
    Filed: August 8, 2007
    Publication date: March 20, 2008
    Applicants: IMMUNO-BIOLOGICAL LABORATORIES CO., LTD., Astellas Pharma Inc.
    Inventors: Toshimitsu UEDE, Shigeyuki Kon, Yukihiko Saeki, Yasuyuki Yokosaki, Masaki Noda, Nobuchika Yamamoto
  • Anti-osteopontin antibody and use thereof
    Publication number: 20040234524
    Abstract: An anti-osteopontin antibody which inhibits the binding of an integrin recognizing RGD sequence to osteopontin or its fragment, and which inhibits the binding of an integrin recognizing SVVYGLR sequence or sequence equivalent thereto to osteopontin or its fragment. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.
    Type: Application
    Filed: May 20, 2004
    Publication date: November 25, 2004
    Inventors: Toshimitsu Uede, Shigeyuki Kon, Yukihiko Saeki, Yasuyuki Yokosaki, Masaki Noda, Nobuchika Yamamoto